Results 181 to 190 of about 54,665 (221)
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Cellular and Molecular Neurobiology, 1995
The cholecystokinin (CCK) and gastrin families of peptides act as hormones and neuropeptides on central and peripheral CCK receptors to mediate secretion and motility in the gastrointestinal (GI) tract in the physiological response to a normal meal. CCK and its receptors are also widely distributed in the central nervous system (CNS) and contribute to
P, Boden, M D, Hall, J, Hughes
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The cholecystokinin (CCK) and gastrin families of peptides act as hormones and neuropeptides on central and peripheral CCK receptors to mediate secretion and motility in the gastrointestinal (GI) tract in the physiological response to a normal meal. CCK and its receptors are also widely distributed in the central nervous system (CNS) and contribute to
P, Boden, M D, Hall, J, Hughes
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Current Opinion in Endocrinology, Diabetes & Obesity, 2007
The hormone cholecystokinin was discovered in 1928 because of its ability to induce gallbladder contraction. Since then, cholecystokinin has been shown to possess multiple functions in the gastrointestinal tract and brain. This review discusses several significant developments in cholecystokinin biology that show how it plays a role in gastrointestinal
Rashmi, Chandra, Rodger A, Liddle
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The hormone cholecystokinin was discovered in 1928 because of its ability to induce gallbladder contraction. Since then, cholecystokinin has been shown to possess multiple functions in the gastrointestinal tract and brain. This review discusses several significant developments in cholecystokinin biology that show how it plays a role in gastrointestinal
Rashmi, Chandra, Rodger A, Liddle
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Hormone and Metabolic Research, 1986
The three classes of CCK antagonists illustrate the various factors governing affinity of the antagonists for the CCK receptor. The major influence in determining potency of the cyclic nucleotide derivatives, amino acid derivatives and C-terminal fragments of CCK, are hydrophobic forces.
P N, Maton, R T, Jensen, J D, Gardner
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The three classes of CCK antagonists illustrate the various factors governing affinity of the antagonists for the CCK receptor. The major influence in determining potency of the cyclic nucleotide derivatives, amino acid derivatives and C-terminal fragments of CCK, are hydrophobic forces.
P N, Maton, R T, Jensen, J D, Gardner
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Current Opinion in Endocrinology, Diabetes & Obesity, 2012
Cholecystokinin (CCK) controls nutrient delivery to the small intestine by inhibiting food intake and gastric emptying. This review deals with recent work shedding new light on how and when.Intestinal I-cells release CCK in response to dietary lipid and protein through mechanisms involving the G-protein-coupled receptors GPR40 and calcium-sensing ...
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Cholecystokinin (CCK) controls nutrient delivery to the small intestine by inhibiting food intake and gastric emptying. This review deals with recent work shedding new light on how and when.Intestinal I-cells release CCK in response to dietary lipid and protein through mechanisms involving the G-protein-coupled receptors GPR40 and calcium-sensing ...
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Comprehensive Physiology, 1980
Abstract The sections in this article are: Definition of Cholecystokinin History of Cholecystokinin Digestive Juice Era Peptide ...
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Abstract The sections in this article are: Definition of Cholecystokinin History of Cholecystokinin Digestive Juice Era Peptide ...
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Progress in Neuro-Psychopharmacology and Biological Psychiatry, 1988
1. CCK-peptides are distributed throughout the whole brain with the exception of the cerebellum. 2. There is strong evidence that they act as neuromodulators on the noradrenergic, opioid and mainly dopaminergic system. 3. CCK reduces food-intake. However, tolerance occurs, when chronically given.
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1. CCK-peptides are distributed throughout the whole brain with the exception of the cerebellum. 2. There is strong evidence that they act as neuromodulators on the noradrenergic, opioid and mainly dopaminergic system. 3. CCK reduces food-intake. However, tolerance occurs, when chronically given.
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Annual Review of Physiology, 1997
▪ Abstract  Cholecystokinin (CCK) is an important hormonal regulator of the digestive process. CCK cells are concentrated in the proximal small intestine, and hormone is secreted into the blood upon the ingestion of food. The physiological actions of CCK include stimulation of pancreatic secretion and gallbladder contraction, regulation of gastric ...
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▪ Abstract  Cholecystokinin (CCK) is an important hormonal regulator of the digestive process. CCK cells are concentrated in the proximal small intestine, and hormone is secreted into the blood upon the ingestion of food. The physiological actions of CCK include stimulation of pancreatic secretion and gallbladder contraction, regulation of gastric ...
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Nature Chemical Biology, 2021
Targeting cholecystokinin receptors (CCKRs) signaling has become an attractive therapeutic strategy for many diseases. The description of cryo-EM structures of CCKRs in the active or inactive states reveal the molecular mechanism of ligand recognition and G-protein-coupling promiscuity.
Lin Cheng, Zhenhua Shao
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Targeting cholecystokinin receptors (CCKRs) signaling has become an attractive therapeutic strategy for many diseases. The description of cryo-EM structures of CCKRs in the active or inactive states reveal the molecular mechanism of ligand recognition and G-protein-coupling promiscuity.
Lin Cheng, Zhenhua Shao
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Cholecystokinin receptor antagonists
American Journal of Physiology-Gastrointestinal and Liver Physiology, 1984Since 1979 three classes of cholecystokinin receptor antagonists have been described: 1) derivatives of cyclic nucleotides, 2) derivatives of amino acids, and 3) C-terminal fragments or partial sequences of cholecystokinin. These various antagonists share a number of common features, such as their specific, reversible, and competitive actions, but ...
J D, Gardner, R T, Jensen
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