Dietary medium chain triglycerides impairs orexigenic action of ghrelin in mice [PDF]
Frontiers in EndocrinologyIntroductionGhrelin, a stomach-derived hormone, increases food intake and body weight. Efforts have been made therefore to modulate ghrelin signaling for the treatment of obesity or emaciation.
Daisuke Aotani +15 more
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The oncogenic role of the In1-ghrelin splicing variant in prostate cancer aggressiveness
Molecular Cancer, 2017 Background The Ghrelin-system is a complex, pleiotropic family composed of several peptides, including native-ghrelin and its In1-ghrelin splicing variant, and receptors (GHSR 1a/b), which are dysregulated in various endocrine-related tumors, where they ...
Manuel D Gahete +2 more
exaly +3 more sources
The long non-coding RNA GHSROS reprograms prostate cancer cell lines toward a more aggressive phenotype [PDF]
PeerJ, 2021 It is now appreciated that long non-coding RNAs (lncRNAs) are important players in orchestrating cancer progression. In this study we characterized GHSROS, a human lncRNA gene on the opposite DNA strand (antisense) to the ghrelin receptor gene, in ...
Patrick B. Thomas +14 more
doaj +2 more sources
Ghrelin and Cancer: Examining the Roles of the Ghrelin Axis in Tumor Growth and Progression
Biomolecules, 2022 Ghrelin, a hormone produced and secreted from the stomach, is prim arily known as an appetite stimulant. Recently, it has emerged as a potential regulator/biomarker of cancer progression.
Anuhya S. Kotta +4 more
doaj +1 more source
Chronic central administration of Ghrelin increases bone mass through a mechanism independent of appetite regulation. [PDF]
PLoS ONE, 2013 Leptin plays a critical role in the central regulation of bone mass. Ghrelin counteracts leptin. In this study, we investigated the effect of chronic intracerebroventricular administration of ghrelin on bone mass in Sprague-Dawley rats (1.5 μg/day for 21
Hyung Jin Choi +11 more
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Veterinary Sciences, 2023 Appetite abnormalities and weight loss are important comorbidities in the treatment of chronic kidney disease (CKD) in cats. Ghrelin, a key hormone involved in the regulation of appetite and metabolism, is a potential marker of appetite dysregulation in ...
Katelyn Brusach +7 more
doaj +1 more source
Aquaculture Reports, 2023 Ghrelin has been well known as an orexigenic hormone that regulates appetite and energy metabolism in animals. Recent studies imply the regulatory function of ghrelin on ovary development, however, the mechanism about the effects of ghrelin on key ...
Jiamin Pi +7 more
doaj +1 more source
A novel human ghrelin variant (In1-ghrelin) and ghrelin-O-acyltransferase are overexpressed in breast cancer: potential pathophysiological relevance. [PDF]
PLoS ONE, 2011 The human ghrelin gene, which encodes the ghrelin and obestatin peptides, contains 5 exons (Ex), with Ex1-Ex4 encoding a 117 amino-acid (aa) preproprotein that is known to be processed to yield a 28-aa (ghrelin) and/or a 23-aa (obestatin) mature peptides,
Manuel D Gahete +7 more
doaj +1 more source
A review on ghrelin and fish reproduction
Reproduction and Breeding, 2021 Ghrelin is a multifunctional peptide hormone which dominantly secreted in stomach and intestine. Ghrelin involves in growth control, food intake, energy balance, and reproductive process.
Huan Zhong, Yi Hu, Fan Yu
doaj +1 more source
Ghrelin Decreases Firing Activity of Gonadotropin-Releasing Hormone (GnRH) Neurons in an Estrous Cycle and Endocannabinoid Signaling Dependent Manner. [PDF]
, 2013 The orexigenic peptide, ghrelin is known to influence function of GnRH neurons, however, the direct effects of the hormone upon these neurons have not been explored, yet.
Farkas, Imre +3 more
core +2 more sources