Results 11 to 20 of about 31,273 (172)
“A LEAP 2 conclusions? Targeting the ghrelin system to treat obesity and diabetes”
Molecular Metabolism, 2021 Background: The hormone ghrelin stimulates food intake, promotes adiposity, increases body weight, and elevates blood glucose. Consequently, alterations in plasma ghrelin levels and the functioning of other components of the broader ghrelin system have ...
Deepali Gupta +4 more
doaj +1 more source
Insights from engraftable immunodeficient mouse models of hyperinsulinaemia
Scientific Reports, 2017 Hyperinsulinaemia, obesity and dyslipidaemia are independent and collective risk factors for many cancers. Here, the long-term effects of a 23% Western high-fat diet (HFD) in two immunodeficient mouse strains (NOD/SCID and Rag1 −/−) suitable for ...
Michelle L. Maugham +11 more
doaj +1 more source
The oncogenic role of the In1-ghrelin splicing variant in prostate cancer aggressiveness
Molecular Cancer, 2017 Background The Ghrelin-system is a complex, pleiotropic family composed of several peptides, including native-ghrelin and its In1-ghrelin splicing variant, and receptors (GHSR 1a/b), which are dysregulated in various endocrine-related tumors, where they ...
Daniel Hormaechea-Agulla +18 more
doaj +1 more source
Hindbrain ghrelin receptor signaling is sufficient to maintain fasting glucose. [PDF]
PLoS ONE, 2012 The neuronal coordination of metabolic homeostasis requires the integration of hormonal signals with multiple interrelated central neuronal circuits to produce appropriate levels of food intake, energy expenditure and fuel availability.
Michael M Scott +8 more
doaj +1 more source
Different forms of ghrelin exhibit distinct biological roles in tilapia
Frontiers in Endocrinology, 2013 Ghrelin has been identified in all vertebrate classes, including sharks. Each species possesses multiple forms of ghrelin that vary in peptide length and acyl modifications (e.g.
Larry eRiley
doaj +1 more source
Altered lipid and salt taste responsivity in ghrelin and GOAT null mice. [PDF]
PLoS ONE, 2013 Taste perception plays an important role in regulating food preference, eating behavior and energy homeostasis. Taste perception is modulated by a variety of factors, including gastric hormones such as ghrelin. Ghrelin can regulate growth hormone release,
Huan Cai +7 more
doaj +1 more source
Journal of Obesity & Metabolic Syndrome, 2017 Background : Desacyl ghrelin is acylated by ghrelin O-acyltransferase (GOAT) and converted to acyl ghrelin. To date, little is known about the relationship among the levels of these two forms of ghrelin, GOAT level, and insulin resistance in Asian ...
Young Hye Cho +11 more
doaj +1 more source
Altered ghrelin secretion in mice in response to diet-induced obesity and Roux-en-Y gastric bypass
Molecular Metabolism, 2014 The current study examined potential mechanisms for altered circulating ghrelin levels observed in diet-induced obesity (DIO) and following weight loss resulting from Roux-en-Y gastric bypass (RYGB).
Aki Uchida +5 more
doaj +1 more source
Cardioprotective effect of ghrelin in cardiopulmonary bypass involves a reduction in inflammatory response. [PDF]
PLoS ONE, 2013 BACKGROUND: Ghrelin has been reported to protect the cardiovascular system; however, the cardioprotective effect of ghrelin against cardiopulmonary bypass (CPB) induced myocardial injury are unclear. In this study, the protective effect of ghrelin on CPB
Yukun Cao +6 more
doaj +1 more source
Periodontitis and metabolic diseases (diabetes and obesity): Tackling multimorbidity
Periodontology 2000, EarlyView., 2023 Abstract Noncommunicable diseases (NCDs) are multifactorial, long‐term, chronic conditions that represent a burden to health‐care systems worldwide as they can only be controlled rather than cured; hence, they require long‐term care. With the exponential increase in NCDs, the occurrence of individuals presenting with more than one chronic disease is ...
Crystal Marruganti +2 more
wiley +1 more source