Results 41 to 50 of about 43,755 (242)
International Journal of Peptides, 2010 Rikkunshito is a popular Japanese traditional medicine that is prescribed in Japan to treat various gastrointestinal tract disorders. In a double-blind controlled study, rikkunshito significantly ameliorated dysmotility-like dyspepsia and brought about a generalized improvement in upper gastric symptoms such as nausea and anorexia when compared with a ...
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JCI Insight, 2021 Mechanisms underlying postprandial and obesity-associated plasma ghrelin reductions are incompletely understood. Here, using ghrelin cell–selective insulin receptor–KO (GhIRKO) mice, we tested the impact of insulin, acting via ghrelin cell–expressed ...
Kripa Shankar +9 more
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GABAB Receptor Blockade Prevents Antiepileptic Action of Ghrelin in the Rat Hippocampus [PDF]
Advanced Pharmaceutical Bulletin, 2013 Purpose: Ghrelin has been shown to have antiepileptic function. However, the underlying mechanisms by which, ghrelin exerts its antiepileptic effects are still unclear.
Zohreh Ataie +5 more
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MOLECULAR EVOLUTION OF GPCRS: Ghrelin/ghrelin receptors [PDF]
Journal of Molecular Endocrinology, 2013 After the discovery in 1996 of the GH secretagogue-receptor type-1a (GHS-R1a) as an orphan G-protein coupled receptor, many research groups attempted to identify the endogenous ligand. Finally, Kojima and colleagues successfully isolated the peptide ligand from rat stomach extracts, determined its structure, and named it ghrelin.
Hiroyuki, Kaiya +2 more
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Cardioprotective effect of ghrelin in cardiopulmonary bypass involves a reduction in inflammatory response. [PDF]
PLoS ONE, 2013 BACKGROUND: Ghrelin has been reported to protect the cardiovascular system; however, the cardioprotective effect of ghrelin against cardiopulmonary bypass (CPB) induced myocardial injury are unclear. In this study, the protective effect of ghrelin on CPB
Yukun Cao +6 more
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Frontiers in Endocrinology, 2022 Ghrelin, a stomach-produced hormone, is well-recognized for its role in promoting feeding, controlling energy homeostasis, and glucoregulation. Ghrelin’s function to ensure survival extends beyond that: its release parallels that of corticosterone, and ...
Stina Börchers +16 more
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Ghrelin: Ghrelin as a Regulatory Peptide in Growth Hormone Secretion [PDF]
Journal of Clinical and Diagnostic Research, 2014 Background: Ghrelin is a type of growth hormone (GH) secretagogue that stimulates the release of GH. It is a first hormone linking gastrointestinal-pituitary axis.
Nazli Khatib +6 more
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Molecular and Cellular Endocrinology, 2011 Ghrelin is a peptide hormone that was originally isolated from the stomach as the endogenous ligand for the growth hormone secretagogue receptor (GHSR). Ghrelin has many functions, including the regulation of appetite and gut motility, growth hormone release from the anterior pituitary and roles in the cardiovascular and immune systems. Ghrelin and its
Chopin, Lisa +7 more
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Ghrelin and the Hyposomatotropism of Obesity [PDF]
Obesity Research, 2002 AbstractObjective: Human obesity is characterized by growth hormone (GH) deficiency, which appears primarily related to a central pattern of obesity and is reverted on weight loss. As yet, the metabolic basis of the GH deficiency remains to be elucidated. The recently discovered endogenous ligand for the GH secretagogue receptor, ghrelin, stimulates GH
Lindeman, J.H.N. +5 more
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Acylation, a Conductor of Ghrelin Function in Brain Health and Disease
Frontiers in Physiology, 2022 Acyl-ghrelin (AG) is an orexigenic hormone that has a unique octanoyl modification on its third serine residue. It is often referred to as the “hunger hormone” due to its involvement in stimulating food intake and regulating energy homeostasis.
Alanna S. Thomas +4 more
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