Results 41 to 50 of about 31,273 (172)

Acyl modifications in bovine, porcine, and equine ghrelins

Frontiers in Endocrinology
Ghrelin is a peptide hormone with various important physiological functions. The unique feature of ghrelin is its serine 3 acyl-modification, which is essential for ghrelin activity.
Takanori Ida, Hatsumi Tominaga, Eri Iwamoto, Akito Kurogi, Ayaka Okura, Kengo Shimada, Johji Kato, Atsutoshi Kuwano, Hirotaka Ode, Sayaka Nagata, Kazuo Kitamura, Takashi Yazawa, Miho Sato-Hashimoto, Masahiro Yasuda, Mikiya Miyazato, Yuki Shiimura, Takahiro Sato, Masayasu Kojima   +17 more
doaj   +1 more source

Time‐Restricted Eating on Appetite and Inflammation in Adults With Obesity and Prediabetes: A Randomized Feeding Study

Obesity, EarlyView.
ABSTRACT Objective Time‐restricted eating (TRE) has gained attention for weight loss and cardiometabolic health improvement. The Time‐Restricted Intake of Meals (TRIM) study was a 12‐week randomized isocaloric and eucaloric feeding trial comparing 10‐h TRE to a 16‐h usual eating pattern (UEP) in adults with obesity and either prediabetes or diet ...
Daisy Duan, Susan Carnell, Scott J. Pilla, Stephanie T. Chung, Jeanne M. Clark, Nisa M. Maruthur   +5 more
wiley   +1 more source

Evidence map and gap analysis of metabolic change in pediatric growth hormone deficiency treated with growth hormone

Pediatric Investigation, EarlyView.
This evidence map of 63 studies (n = 6158) showed growth hormone therapy in children with growth hormone deficiency has neutral glucose effects, mixed lipid outcomes, potential benefits for bone mineral density, bone mineral content, and parathyroid hormone, but generally no impact on thyroid function, body composition, or body mass index.
Wei Wu, Ningyi Song, Yue Zhao, Caiqi Du, Yuning Zhao, You Wu, Xiaoping Luo   +6 more
wiley   +1 more source

Regulation of the Human Ghrelin Promoter Activity by Transcription Factors, NF-κB and Nkx2.2

International Journal of Endocrinology, 2015
To examine the gene expression of ghrelin, a growth hormone releasing and appetite stimulating hormone from stomach, we constructed human ghrelin promoter-reporter vectors and analyzed the promoter activity.
Yuki Shiimura, Hideko Ohgusu, Takahiro Sato, Masayasu Kojima   +3 more
doaj   +1 more source

Sodium Ions Affect GPR17 Conformational States and Functionality

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Sodium is an allosteric modulator of several class‐A GPCR regulating active versus inactive conformation state and may be a critical issue for the optimization of crystallization procedures. Herein, the role of Na+ in the regulation of GPR17 conformational states was studied through MD simulations of GPR17 wild‐type and mutated on two ...
Luca Palazzolo, Simona Daniele, Davide Bianchi, Lara Russo, Stefano Capaldi, Maria Letizia Trincavelli, Ivano Eberini   +6 more
wiley   +1 more source

Ghrelin and LEAP2: Their Interaction Effect on Appetite Regulation and the Alterations in Their Levels Following Bariatric Surgery

Medicina
Background and Objectives: Ghrelin plays key roles in appetite regulation, involving both homeostatic and hedonic pathways. In obesity, its metabolism is affected by alterations in neural and hormonal responses.
Nese Alic, Aylin Ayaz
doaj   +1 more source

Novel regulator of acylated ghrelin, CF801, reduces weight gain, rebound feeding after a fast, and adiposity in mice

Frontiers in Endocrinology, 2015
Ghrelin is a 28 amino-acid hormonal peptide that is intimately related to the regulation of food intake and body weight. Once secreted, ghrelin binds to the growth hormone secretagogue receptor-1a (GHSR-1a), the only known receptor for ghrelin and is ...
Martin K Wellman, Zachary Robert Patterson, Harry eMackay, Joseph E Darling, Bharath K Mani, Jeffrey eZigman, James L Hougland, Alfonso eAbizaid   +7 more
doaj   +1 more source

Using programmable infusion pump in avian species – a validation methodology in geese

Wildlife Biology, EarlyView.
Wildlife face anthropogenic and natural stressors that affect their physiology and behaviour. The activity of the hypothalamic–pituitary–adrenal axis and glucocorticoid (GC) production is intrinsically linked with energy regulation and environmental stressors.
Myriam Trottier‐Paquet, Maude Gauthier‐Bouchard, Akiko Kato, Charline Parenteau, Frédéric Angelier, Pierre Legagneux   +5 more
wiley   +1 more source

Liver-expressed antimicrobial peptide 2 elevation contributes to age-associated cognitive decline

JCI Insight, 2023
Elderly individuals frequently report cognitive decline, while various studies indicate hippocampal functional declines with advancing age. Hippocampal function is influenced by ghrelin through hippocampus-expressed growth hormone secretagogue receptor ...
Jing Tian, Lan Guo, Tienju Wang, Kun Jia, Russell H. Swerdlow, Jeffrey M. Zigman, Heng Du   +6 more
doaj   +1 more source

Sensing of fatty acids for octanoylation of ghrelin involves a gustatory G-protein. [PDF]

PLoS ONE, 2012
BackgroundGhrelin is an important regulator of energy--and glucose homeostasis. The octanoylation at Ser(3) is essential for ghrelin's biological effects but the mechanisms involved in the octanoylation are unknown.
Sara Janssen, Jorien Laermans, Hiroshi Iwakura, Jan Tack, Inge Depoortere   +4 more
doaj   +1 more source