Altered ghrelin secretion in mice in response to diet-induced obesity and Roux-en-Y gastric bypass
Molecular Metabolism, 2014 The current study examined potential mechanisms for altered circulating ghrelin levels observed in diet-induced obesity (DIO) and following weight loss resulting from Roux-en-Y gastric bypass (RYGB).
Aki Uchida +5 more
doaj +1 more source
Influence of netball-based exercise on energy intake, subjective appetite and plasma acylated ghrelin in adolescent girls [PDF]
, 2013 This study explored 5-d regulation of exercise-induced energy expenditure, energy intake, and hormonal appetite, via acylated ghrelin, after acute exercise. Using a randomized crossover design, 10 female adolescents (13-15 y) completed two 7-d treatment
Stevenson, Emma +14 more
core +1 more source
Cardioprotective effect of ghrelin in cardiopulmonary bypass involves a reduction in inflammatory response. [PDF]
PLoS ONE, 2013 BACKGROUND: Ghrelin has been reported to protect the cardiovascular system; however, the cardioprotective effect of ghrelin against cardiopulmonary bypass (CPB) induced myocardial injury are unclear. In this study, the protective effect of ghrelin on CPB
Yukun Cao +6 more
doaj +1 more source
JCI Insight, 2021 Mechanisms underlying postprandial and obesity-associated plasma ghrelin reductions are incompletely understood. Here, using ghrelin cell–selective insulin receptor–KO (GhIRKO) mice, we tested the impact of insulin, acting via ghrelin cell–expressed ...
Kripa Shankar +9 more
doaj +1 more source
Ghrelin Alleviates Aging-Related Cognitive Impairment by Regulating Autophagy-Related Signaling via the SHBG/JNK1/Beclin1 Axis in Microglia. [PDF]
Aging CellThis study found that aging‐related cognitive impairment is accompanied by hippocampal microglial senescence. Ghrelin suppresses microglial senescence by promoting autophagy through the SHBG/JNK1/Beclin1 axis, thereby alleviating aging‐related cognitive impairment. The graphical abstract was drawn using the Figdraw.
Zhou L +9 more
europepmc +2 more sources
Ablation of ghrelin O-acyltransferase does not improve glucose intolerance or body adiposity in mice on a leptin-deficient ob/ob background. [PDF]
PLoS ONE, 2013 Type 2 Diabetes is a global health burden and based on current estimates will become an even larger problem in the future. Developing new strategies to prevent and treat diabetes is a scientific challenge of high priority. The stomach hormone ghrelin has
Henriette Kirchner +5 more
doaj +1 more source
Frontiers in Endocrinology, 2022 Ghrelin, a stomach-produced hormone, is well-recognized for its role in promoting feeding, controlling energy homeostasis, and glucoregulation. Ghrelin’s function to ensure survival extends beyond that: its release parallels that of corticosterone, and ...
Stina Börchers +16 more
doaj +1 more source
GABAB Receptor Blockade Prevents Antiepileptic Action of Ghrelin in the Rat Hippocampus [PDF]
Advanced Pharmaceutical Bulletin, 2013 Purpose: Ghrelin has been shown to have antiepileptic function. However, the underlying mechanisms by which, ghrelin exerts its antiepileptic effects are still unclear.
Zohreh Ataie +5 more
doaj +1 more source
Periodontitis and metabolic diseases (diabetes and obesity): Tackling multimorbidity
Periodontology 2000, EarlyView., 2023 Abstract Noncommunicable diseases (NCDs) are multifactorial, long‐term, chronic conditions that represent a burden to health‐care systems worldwide as they can only be controlled rather than cured; hence, they require long‐term care. With the exponential increase in NCDs, the occurrence of individuals presenting with more than one chronic disease is ...
Crystal Marruganti +2 more
wiley +1 more source
Ghrelin: Ghrelin as a Regulatory Peptide in Growth Hormone Secretion [PDF]
Journal of Clinical and Diagnostic Research, 2014 Background: Ghrelin is a type of growth hormone (GH) secretagogue that stimulates the release of GH. It is a first hormone linking gastrointestinal-pituitary axis.
Nazli Khatib +6 more
doaj +1 more source