Results 1 to 10 of about 5,351 (110)

Temporal control of eating and body weight by GHSR-expressing suprachiasmatic nucleus neurons [PDF]

Cell Reports
Summary: Food consumption impacts body weight differently depending on the time of day. Here, we investigated whether suprachiasmatic nucleus (SCN) neurons responsive to the hormone ghrelin temporally regulate eating and body weight in mice.
Jeffrey Zigman
exaly   +4 more sources

GHSR deficiency exacerbates Parkinson's disease pathology by impairing autophagy

Redox Biology
In Parkinson's disease (PD), exogenous ghrelin protects dopaminergic neurons through its receptor, growth hormone secretagogue receptor (GHSR). However, in contrast to the strikingly low levels of ghrelin, GHSR is highly expressed in the substantia nigra
, Qian Jiao, Mingxia Bi
exaly   +3 more sources

Myeloid GHSR Deficiency Protects Against Thermogenic Impairment in Aging Through Immune Remodeling of Brown Adipose Tissue [PDF]

Cells
Thermoregulatory dysfunction is a major pathophysiological consequence of aging, affecting many elderly individuals. Growth hormone secretagogue receptor (GHSR) regulates energy homeostasis and immune function.
Hye Won Han, Da Mi Kim, Reza Baratiboldaji, Hongying Wang, Zeyu Liu, Zheng Shen, Deepak K. Jha, Tadesse Teferra, Endang M. Septiningsih, Bhimanagouda Patil, Yuxiang Sun   +10 more
doaj   +2 more sources

GHSR‐Foxo1 Signaling in Macrophages Promotes Liver Fibrosis via Inflammatory Response and Hepatic Stellate Cell Activation [PDF]

Advanced Science
Liver fibrosis is a severe liver disease directly linked to chronic inflammation, in which hepatic macrophages play a key role. Growth hormone secretagogue receptor (GHSR) is the receptor of nutrient‐sensing hormone ghrelin that has essential functions ...
Da Mi Kim, Quan Pan, Zeyu Liu, Weiqi Ai, Hye Won Han, Sakhila K. Banu, Robert Y.L. Tsai, Gus A. Wright, Shaodong Guo, Yuxiang Sun   +9 more
doaj   +2 more sources

KARIs, Ghrelin Receptor Agonists With Excellent Brain Permeability, Increase Food Intake and Attenuate the Muscle Loss in Mice [PDF]

Journal of Cachexia, Sarcopenia and Muscle
Background Ghrelin regulates appetite, gastrointestinal motility and growth hormone (GH) secretion through activation of the growth hormone secretagogue receptor (GHSR‐1a) in hypothalamic neurons, with downstream effects on adipose tissue and skeletal ...
Hee Ji Yoon, Wan Hui Han, Sang Bo Kim, Won Gyeong Lee, Seo Young Choi, Byung Jo Choi, Minyeong Pang, Min‐Koo Choi, Jihoon Lee, Im‐Sook Song, Min Hee Park, Hee Kyung Jin, Jae‐sung Bae   +12 more
doaj   +2 more sources

Growth Hormone Secretagogue Receptor (GHSR) Is Elevated in Myocardial Tissues of DMD mdx:utrn^−/− Mice, and Correlates Strongly with Inflammatory Markers, and Negatively with Cardiac Function [PDF]

Cells
Dilated cardiomyopathy affects greater than 1 in 2500 patients worldwide, including those with the neuromuscular disorder Duchenne muscular dystrophy (DMD).
Maedeh Naghibosadat, Andrew McClennan, Margarita Egiian, Reema Flynn-Rizk, Tyler Lalonde, Carlie Charron, Anish Chhabra, Leonard G. Luyt, Savita Dhanvantari, Lisa M. Hoffman   +9 more
doaj   +2 more sources

Neuronal ablation of GHSR mitigates diet-induced depression and memory impairment via AMPK-autophagy signaling-mediated inflammation

Frontiers in Immunology
Obesity is associated with chronic inflammation in the central nervous system (CNS), and neuroinflammation has been shown to have detrimental effects on mood and cognition.
Xiaoqiu Xiao, Chia Shan Wu, Yuxiang Sun   +2 more
exaly   +3 more sources

Midbrain ghrelin receptor signalling regulates binge drinking in a sex specific manner [PDF]

Nature Communications
Risky drinking rates are rising, particularly in women, yet sex as a biological variable has only recently gained traction. The centrally projecting Edinger-Westphal (EWcp) nucleus has emerged as a key regulator of alcohol consumption. Here we found that
Amy J. Pearl, Xavier J. Maddern, Paulo Pinares-Garcia, Lauren T. Ursich, Roberta G. Anversa, Arnav Shesham, Robyn M. Brown, Felicia M. Reed, William J. Giardino, Andrew J. Lawrence, Leigh C. Walker   +10 more
doaj   +2 more sources

LEAP2 Impairs the Capability of the Growth Hormone Secretagogue Receptor to Regulate the Dopamine 2 Receptor Signaling

Frontiers in Pharmacology, 2021
The growth hormone secretagogue receptor (GHSR) signals in response to ghrelin, but also acts via ligand-independent mechanisms that include either constitutive activation or interaction with other G protein-coupled receptors, such as the dopamine 2 ...
Emilio R. Mustafá, Santiago Cordisco González, Marjorie Damian, Sonia Cantel, Severine Denoyelle, Renaud Wagner, Helgi B. Schiöth, Helgi B. Schiöth, Jean-Alain Fehrentz, Jean-Louis Banères, Mario Perelló, Jesica Raingo   +11 more
doaj   +1 more source

Growth hormone secretagogue receptor‐1a mediates ghrelin's effects on attenuating tumour‐induced loss of muscle strength but not muscle mass

Journal of Cachexia, Sarcopenia and Muscle, 2021
Background Ghrelin may ameliorate cancer cachexia (CC) by preventing anorexia, muscle, and fat loss. However, the mechanisms mediating these effects are not fully understood. This study characterizes the pathways involved in muscle mass and strength loss
Haiming Liu, Pu Zang, Ian (In‐gi) Lee, Barbara Anderson, Anthony Christiani, Lena Strait‐Bodey, Beatrice A. Breckheimer, Mackenzie Storie, Alison Tewnion, Kora Krumm, Theresa Li, Brynn Irwin, Jose M. Garcia   +12 more
doaj   +1 more source