Results 11 to 20 of about 5,420 (161)

GHSR agonism increases blood glucose but delays food intake in GHSR hyperresponsive rats. [PDF]

J Neuroendocrinol
GHSR agonism increases blood glucose, inhibits locomotor activity and delays food intake in GHSR hyperresponsive rats. Abstract Severe calorie restriction in mouse models has highlighted the crucial role of the ghrelin system in maintaining glycemia and promoting survival.
Zizzari P, Ramírez-Penas O, Pons V, Oujezdska M, Sammarcelli AL, Saint-Yves T, Chevallier-Chantepie I, Baussart L, Nhan V, Phalip A, Gales C, Cota D, Noble F, Pantel J.   +13 more
europepmc   +4 more sources

Genetic deletion of the ghrelin receptor (GHSR) impairs growth and blunts endocrine response to fasting in Ghsr-IRES-Cre mice

Molecular Metabolism, 2021
Objective: The orexigenic hormone ghrelin exerts its physiological effects by binding to and activating the growth hormone secretagogue receptor (GHSR). The recent development of a Ghsr-IRES-Cre knock-in mouse line has enabled to genetically access GHSR ...
Fiona Peris-Sampedro, Iris Stoltenborg, Marie V. Le May, Jeffrey M. Zigman, Roger A.H. Adan, Suzanne L. Dickson   +5 more
doaj   +4 more sources

Metabolic insights from a GHSR-A203E mutant mouse model

Molecular Metabolism, 2020
Objective: Binding of ghrelin to its receptor, growth hormone secretagogue receptor (GHSR), stimulates GH release, induces eating, and increases blood glucose. These processes may also be influenced by constitutive (ghrelin-independent) GHSR activity, as
Lola J. Torz, Sherri Osborne-Lawrence, Juan Rodriguez, Zhenyan He, María Paula Cornejo, Emilio Román Mustafá, Chunyu Jin, Natalia Petersen, Morten A. Hedegaard, Maja Nybo, Valentina Martínez Damonte, Nathan P. Metzger, Bharath K. Mani, Kevin W. Williams, Jesica Raingo, Mario Perello, Birgitte Holst, Jeffrey M. Zigman   +17 more
doaj   +6 more sources

Loss-of-Function GHSR Variants Are Associated With Short Stature and Low IGF-I [PDF]

Journal of Clinical Endocrinology and Metabolism
Abstract Context The growth hormone (GH) secretagogue receptor, encoded by GHSR, is expressed on somatotrophs of the pituitary gland. Stimulation with its ligand ghrelin, as well as its constitutive activity, enhances GH secretion. Studies in knockout mice suggest that heterozygous loss-of-function of
, Jenny A Visser, Sander Kooijman
exaly   +8 more sources

GHSR-Targeted PET Imaging Probe. [PDF]

ACS Med Chem Lett
Song R, Liang SH.
europepmc   +2 more sources

Ghrelin Receptor Deletion or Pharmacological Inhibition Improves Muscle Function in Aging Male Mice. [PDF]

Aging Cell
Ghrelin receptor (GHSR‐1a) deletion and pharmacological inverse agonism improved muscle function and restored mitophagy and mitochondrial biogenesis markers in aged male mice. ABSTRACT Sarcopenia is characterized by age‐related declines in muscle strength and mass, along with impaired physical function.
Kerr HL, Krumm K, Myree N, Rybachok A, Dacek E, Irwin B, Jiang S, Caeiro L, Anderson B, Li T, Chen A, Burnside R, Li J, Sydor M, Marcinek DJ, Merrihew GE, MacDonald JW, Bammler TK, MacCoss MJ, Garcia JM.   +19 more
europepmc   +2 more sources

Detection of recurrent endometrial cancer via DNA methylation analysis of cervicovaginal self-samples and urine. [PDF]

Int J Cancer
What's new? Post‐treatment surveillance for endometrial cancer aims to detect recurrence early, potentially improving outcome. Emerging evidence suggests that DNA methylation analysis of self‐collected cervicovaginal and urine samples is a promising approach.
Nouwens AJ, Schaafsma M, van Trommel NE, Kasius JC, Steenbergen RDM, Bleeker MCG.   +5 more
europepmc   +2 more sources

Contribution of growth hormone secretagogue receptor (GHSR) signaling in the ventral tegmental area (VTA) to the regulation of social motivation in male mice

Translational Psychiatry, 2021
Most psychiatric disorders are characterized by deficits in the ability to interact socially with others. Ghrelin, a hormone normally associated with the regulation of glucose utilization and appetite, is also implicated in the modulation of motivated ...
Su-Bin Park, Samantha King, David MacDonald, Anne Wilson, Harry MacKay, Barbara Woodside, Alfonso Abizaid   +6 more
doaj   +1 more source

Deletion of Growth Hormone Secretagogue Receptor in Kisspeptin Neurons in Female Mice Blocks Diet-Induced Obesity

Biomolecules, 2022
The gut peptide, ghrelin, mediates energy homeostasis and reproduction by acting through its receptor, growth hormone secretagogue receptor (GHSR), expressed in hypothalamic neurons in the arcuate (ARC).
Kristie Conde, Danielle Kulyk, Allison Vanschaik, Sierra Daisey, Catherine Rojas, Kimberly Wiersielis, Ali Yasrebi, Thomas J. Degroat, Yuxiang Sun, Troy A. Roepke   +9 more
doaj   +1 more source

GHSR hypermethylation: a promising pan-cancer marker [PDF]

Cell Cycle, 2015
The advent of high-throughput technologies such as microarrays, global gene knockout, and next generation sequencing (NGS) has revolutionized the field of molecular oncology. Large-scale endeavors of the kind represented by the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA) are generating comprehensive portraits of ...
Pouria, Jandaghi, Jörg D, Hoheisel, Yasser, Riazalhosseini   +2 more
openaire   +2 more sources