Results 11 to 20 of about 6,435 (196)

Myeloid GHSR Deficiency Protects Against Endotoxemia via Macrophage Mitochondrial Reprogramming [PDF]

Biomedicines
Background: Endotoxemia is a severe inflammatory condition that is characterized by acute immune responses and oxidative stress; endotoxemia can further develop into a cytokine storm and sepsis leading to severe organ damage.
Da Mi Kim, Zheng Shen, Quan Pan, Zeyu Liu, Wanbao Yang, Natividad R. Fuentes, Robert S. Chapkin, Gus A. Wright, Bhimanagouda Patil, Shaodong Guo, Yuxiang Sun   +10 more
doaj   +3 more sources

Myeloid GHSR Deficiency Protects Against Thermogenic Impairment in Aging Through Immune Remodeling of Brown Adipose Tissue [PDF]

Cells
Thermoregulatory dysfunction is a major pathophysiological consequence of aging, affecting many elderly individuals. Growth hormone secretagogue receptor (GHSR) regulates energy homeostasis and immune function.
Hye Won Han, Da Mi Kim, Reza Baratiboldaji, Hongying Wang, Zeyu Liu, Zheng Shen, Deepak K. Jha, Tadesse Teferra, Endang M. Septiningsih, Bhimanagouda Patil, Yuxiang Sun   +10 more
doaj   +3 more sources

KARIs, Ghrelin Receptor Agonists With Excellent Brain Permeability, Increase Food Intake and Attenuate the Muscle Loss in Mice [PDF]

Journal of Cachexia, Sarcopenia and Muscle
Background Ghrelin regulates appetite, gastrointestinal motility and growth hormone (GH) secretion through activation of the growth hormone secretagogue receptor (GHSR‐1a) in hypothalamic neurons, with downstream effects on adipose tissue and skeletal ...
Hee Ji Yoon, Wan Hui Han, Sang Bo Kim, Won Gyeong Lee, Seo Young Choi, Byung Jo Choi, Minyeong Pang, Min‐Koo Choi, Jihoon Lee, Im‐Sook Song, Min Hee Park, Hee Kyung Jin, Jae‐sung Bae   +12 more
doaj   +3 more sources

Ghrelin Alleviates Aging‐Related Cognitive Impairment by Regulating Autophagy‐Related Signaling via the SHBG/JNK1/Beclin1 Axis in Microglia [PDF]

Aging Cell, Volume 25, Issue 10, October 2026.
This study found that aging‐related cognitive impairment is accompanied by hippocampal microglial senescence. Ghrelin suppresses microglial senescence by promoting autophagy through the SHBG/JNK1/Beclin1 axis, thereby alleviating aging‐related cognitive impairment. The graphical abstract was drawn using the Figdraw.
Lixing Zhou, Ying Cheng, Wanyu Zhao, Xuelian Sun, Fengjuan Hu, Meiling Ge, Yan Zhang, Gongchang Zhang, Birong Dong, Xiaolei Liu   +9 more
wiley   +2 more sources

Activation of GHSRs Facilitates the Excitability of Dentate Gyrus Granule Cells and Short‐Term Spatial Memory via Multiple Ionic and Signaling Mechanisms [PDF]

Advanced Biology, Volume 10, Issue 8, August 2026.
Ghrelin excites the dentate gyrus (DG) granule cells via GHSR‐mediated modulation of diverse ionic channels and activation of D1R, cAMP, and EPAC2. Similarly, overnight calorie restriction alters neuronal excitability in a ghrelin‐dependent manner. Infusion of ghrelin directly into the DG improves short‐term spatial memory in the Y‐maze, providing ...
Chidiebele S. Oraegbuna, Phani K. Kola, Simon L. Griggs, Saobo Lei   +3 more
wiley   +2 more sources

GHSR deficiency suppresses neointimal formation in injured mouse arteries [PDF]

Biochemical and Biophysical Research Communications, 2016
Growth hormone secretagogue receptor (GHSR) is involved in appetite regulation and energy homeostasis. In the present study, we examined the role of GHSR in neointimal formation following vascular injury. In the mouse model of femoral artery wire injury, we found that vessel intima-to-media ratio was significantly reduced in GHSR deficiency (GHSR ...
Jing, Li, Man, Zhang, Mo, Wang, Zhipeng, Wang, Yahan, Liu, Weizhen, Zhang, Nanping, Wang   +6 more
openaire   +3 more sources

GHSR agonism increases blood glucose but delays food intake in GHSR hyperresponsive rats. [PDF]

J Neuroendocrinol
Abstract Severe calorie restriction in mouse models has highlighted the crucial role of the ghrelin system in maintaining glycemia and promoting survival. We hypothesized that if ghrelin acts as a survival signal, enhancing the responsivity of the GH secretagogue receptor ...
Zizzari P, Ramírez-Penas O, Pons V, Oujezdska M, Sammarcelli AL, Saint-Yves T, Chevallier-Chantepie I, Baussart L, Nhan V, Phalip A, Gales C, Cota D, Noble F, Pantel J.   +13 more
europepmc   +3 more sources

Investigation of GHSR and GHRL Methylation in Colorectal Cancer

Epigenomics, 2018
To investigate GHSR and GHRL methylation in 73 pairs of colorectal cancer (CRC) tissues and healthy adjacent mucosa.Methylation was assessed with methylation-sensitive high-resolution melting.GHSR was significantly hypermethylated in CRC tissues than in healthy mucosa (p 
Coppedè, Fabio, Stoccoro, Andrea, Lazzarotti, Alessandro, Spisni, Roberto, Migliore, Lucia   +4 more
openaire   +4 more sources

GHSR and TLR4 collectively promote hepatic inflammation and aberrant repair in alveolar echinococcosis [PDF]

Frontiers in Immunology
Background and objectiveAlveolar echinococcosis (AE) is a fatal zoonotic parasitic disease that causes progressive hepatic injury through chronic inflammation, aberrant proliferative repair, and liver fibrosis. GHSR and TLR4 individually regulate hepatic
Guangfeng Chen, Guangfeng Chen, Tanfang Zhou, Xia Chen, Ayinula Tuohetali, Ya Song, Mutailipu Maimaiti, Kalibixiati Aimulajiang, Jiang Zhu, Jiang Zhu   +9 more
doaj   +2 more sources

Involvement of the GHSR in the developmental programming and metabolic disturbances induced by maternal undernutrition [PDF]

The Journal of Nutritional Biochemistry, 2020
The mismatch between maternal undernutrition and adequate nutrition after birth increases the risk of developing metabolic diseases. We aimed to investigate whether the hyperghrelinemia during maternal undernourishment rewires the hypothalamic development of the offspring and contributes to the conversion to an obese phenotype when fed a high-fat diet (
Sun, Shu, Corbeels, Katrien, Desmet, Louis, Segers, Anneleen, Wang, Qiaoling, Van der Schueren, Bart, Depoortere, Inge   +6 more
openaire   +4 more sources