Molecular mechanism of agonism and inverse agonism in ghrelin receptor [PDF]
Nature Communications, 2022 Ghrelin receptor regulates energy homeostasis through constitutive activity or by the ghrelin. Here the authors report two structures of ghrelin receptor bound to agonist and inverse agonist, providing insights into the mechanism of inverse agonism ...
Jiao Qin +13 more
doaj +2 more sources
Molecular recognition of an acyl-peptide hormone and activation of ghrelin receptor [PDF]
Nature Communications, 2021 Ghrelin is a gastric peptide hormone and its acylation is required for binding to and activation of the ghrelin receptor in the brain, which initiates appetite.
Yue Wang +10 more
doaj +2 more sources
How the ghrelin receptor recognizes the acyl-modified orexigenic hormone [PDF]
Frontiers in Molecular NeuroscienceGhrelin, discovered in 1999 as an endogenous ligand of the growth hormone secretagogue receptor (now known as the ghrelin receptor), is a peptide hormone with diverse physiological activities, such as stimulation of growth hormone release, increased ...
Yuki Shiimura +3 more
doaj +2 more sources
Targeting the Ghrelin Receptor as a Novel Therapeutic Option for Epilepsy [PDF]
Biomedicines, 2021 Epilepsy is a neurological disease affecting more than 50 million individuals worldwide. Notwithstanding the availability of a broad array of antiseizure drugs (ASDs), 30% of patients suffer from pharmacoresistant epilepsy.
An Buckinx +3 more
doaj +2 more sources
Acylated Ghrelin Receptor Agonist HM01 Decreases Lean Body and Muscle Mass, but Unacylated Ghrelin Protects against Redox-Dependent Sarcopenia [PDF]
Antioxidants, 2022 Sarcopenia, the progressive loss of muscle mass and dysfunction, universally affects the elderly and is closely associated with frailty and reduced quality of life.
Rojina Ranjit +2 more
doaj +2 more sources
Molecular Metabolism, 2018 Objective: The blood–brain barrier (BBB) regulates the entry of substrates and peptides into the brain. Ghrelin is mainly produced in the stomach but exerts its actions in the central nervous system (CNS) by crossing the BBB.
Elizabeth Meredith Rhea +2 more
exaly +3 more sources
Structure of an antagonist-bound ghrelin receptor reveals possible ghrelin recognition mode [PDF]
Nature Communications, 2020 Ghrelin is a gastric peptide hormone with important physiological functions, including growth hormone release and appetite-stimulating activity. Here, authors solved the crystal structure of the ghrelin receptor bound to antagonist and suggested a ...
Yuki Shiimura +10 more
doaj +2 more sources
Role of Dopaminergic and Cannabinoidergic Receptors on Ghrelin-Induced Hypophagia in 5-Day-Old Broiler Chicken [PDF]
Archives of Razi Institute, 2021 The present study aimed to identify the role of dopaminergic and cannabinoidergic systems in the ghrelin-induced hypophagia among meat-type chickens.
R Farrokhi +4 more
doaj +1 more source
Hindbrain ghrelin receptor signaling is sufficient to maintain fasting glucose. [PDF]
PLoS ONE, 2012 The neuronal coordination of metabolic homeostasis requires the integration of hormonal signals with multiple interrelated central neuronal circuits to produce appropriate levels of food intake, energy expenditure and fuel availability.
Michael M Scott +8 more
doaj +1 more source
Ghrelin and Cancer: Examining the Roles of the Ghrelin Axis in Tumor Growth and Progression
Biomolecules, 2022 Ghrelin, a hormone produced and secreted from the stomach, is prim arily known as an appetite stimulant. Recently, it has emerged as a potential regulator/biomarker of cancer progression.
Anuhya S. Kotta +4 more
doaj +1 more source