Results 11 to 20 of about 20,015 (204)

Ghrelin receptors in non-mammalian vertebrates [PDF]

Frontiers in Endocrinology, 2013
The growth hormone secretagogue-receptor (GHS-R) was discovered in humans and pigs in 1996. The endogenous ligand, ghrelin, was discovered three years later, in 1999, and our understanding of the physiological significance of the ghrelin system in ...
Hiroyuki eKaiya, Kenji eKangawa, Mikiya eMiyazato   +2 more
doaj   +3 more sources

Syndecans modulate ghrelin receptor signaling. [PDF]

J Mol Endocrinol
Ghrelin is a gut hormone that enhances food intake and growth hormone secretion through its G-protein coupled receptor, the growth hormone secretagogue receptor (GHSR). Recently, we have shown that ghrelin interacts with syndecans (SDCs), a family of membrane proteins known to modulate hypothalamic appetite signaling. Here, we investigated whether SDCs
Prins K, Mutsters N, Volker F, Huisman M, Mies R, Delhanty PJD, Visser JA.   +6 more
europepmc   +4 more sources

Ghrelin and ghrelin receptor modulation of psychostimulant action [PDF]

Frontiers in Neuroscience, 2013
Ghrelin (GHR) is an orexigenic gut peptide that modulates multiple homeostatic functions including gastric emptying, anxiety, stress, memory, feeding, and reinforcement. GHR is known to bind and activate growth-hormone secretagogue receptors (termed GHR-Rs).
Wellman, Paul J., Clifford, P. Shane, Rodriguez, Juan A.   +2 more
openaire   +3 more sources

MOLECULAR EVOLUTION OF GPCRS: Ghrelin/ghrelin receptors [PDF]

Journal of Molecular Endocrinology, 2013
After the discovery in 1996 of the GH secretagogue-receptor type-1a (GHS-R1a) as an orphan G-protein coupled receptor, many research groups attempted to identify the endogenous ligand. Finally, Kojima and colleagues successfully isolated the peptide ligand from rat stomach extracts, determined its structure, and named it ghrelin.
Hiroyuki, Kaiya, Kenji, Kangawa, Mikiya, Miyazato   +2 more
openaire   +2 more sources

Ghrelin: Ghrelin as a Regulatory Peptide in Growth Hormone Secretion [PDF]

Journal of Clinical and Diagnostic Research, 2014
Background: Ghrelin is a type of growth hormone (GH) secretagogue that stimulates the release of GH. It is a first hormone linking gastrointestinal-pituitary axis.
Nazli Khatib, Shilpa Gaidhane, Abhay M Gaidhane, Mahanaaz Khatib, Padam Simkhada, Dilip Gode, Quazi Syed Zahiruddin   +6 more
doaj   +1 more source

Ghrelin attenuates the osteoblastic differentiation of vascular smooth muscle cells through the ERK pathway. [PDF]

PLoS ONE, 2012
Vascular calcification results from osteoblastic differentiation of vascular smooth muscle cells (VSMCs) and is a major risk factor for cardiovascular events. Ghrelin is a newly discovered bioactive peptide that acts as a natural endogenous ligand of the
Qiu-Hua Liang, Yi Jiang, Xiao Zhu, Rong-Rong Cui, Guan-Ying Liu, Yuan Liu, Shan-Shan Wu, Xiao-Bo Liao, Hui Xie, Hou-De Zhou, Xian-Ping Wu, Ling-Qing Yuan, Er-Yuan Liao   +12 more
doaj   +1 more source

Motilin Stimulates Gastric Acid Secretion in Coordination with Ghrelin in Suncus murinus. [PDF]

PLoS ONE, 2015
Motilin and ghrelin constitute a peptide family, and these hormones are important for the regulation of gastrointestinal motility. In this study, we examined the effect of motilin and ghrelin on gastric acid secretion in anesthetized suncus (house musk ...
Chayon Goswami, Yoshiaki Shimada, Makoto Yoshimura, Anupom Mondal, Sen-ichi Oda, Toru Tanaka, Takafumi Sakai, Ichiro Sakata   +7 more
doaj   +1 more source

Expression of Ghrelin and Its Receptor mRNA in Bovine Oocyte and Cumulus Cells [PDF]

International Journal of Fertility and Sterility, 2019
Energy balance is regulated by ghrelin which is a neuroendocrine modulator. Ghrelin is expressed in repro- ductive organs. However, the role of ghrelin during in vitro maturation (IVM) and bovine preimplantational development is limited. The purpose of
Matías Angel Sirini, Juan Patricio Anchordoquy, Silvina Quintana, Cecilia Furnus, Alejandro Enrique Relling, Juan Mateo Anchordoquy   +5 more
doaj   +1 more source

Periodontitis and metabolic diseases (diabetes and obesity): Tackling multimorbidity

Periodontology 2000, EarlyView., 2023
Abstract Noncommunicable diseases (NCDs) are multifactorial, long‐term, chronic conditions that represent a burden to health‐care systems worldwide as they can only be controlled rather than cured; hence, they require long‐term care. With the exponential increase in NCDs, the occurrence of individuals presenting with more than one chronic disease is ...
Crystal Marruganti, Jean E. Suvan, Francesco D'Aiuto   +2 more
wiley   +1 more source

NPY Receptors Blockade Prevents Anticonvulsant Action of Ghrelin in the Hippocampus of Rat [PDF]

Advanced Pharmaceutical Bulletin, 2013
Purpose: Ghrelin has been shown to have antiepileptic function. However, the underlying mechanisms by which, ghrelin exerts its antiepileptic effects are still unclear.
Mina Ghahramanian Golzar, Shirin Babri, Zohre Ataie, Hadi Ebrahimi, Fariba Mirzaie, Gisou Mohaddes   +5 more
doaj   +1 more source