Results 11 to 20 of about 1,268,458 (245)

Ghrelin decreases firing activity of gonadotropin-releasing hormone (GnRH) neurons in an estrous cycle and endocannabinoid signaling dependent manner. [PDF]

PLoS ONE, 2013
The orexigenic peptide, ghrelin is known to influence function of GnRH neurons, however, the direct effects of the hormone upon these neurons have not been explored, yet.
Imre Farkas, Csaba Vastagh, Miklós Sárvári, Zsolt Liposits   +3 more
doaj   +4 more sources

Syndecans modulate ghrelin receptor signaling. [PDF]

J Mol Endocrinol
Ghrelin is a gut hormone that enhances food intake and growth hormone secretion through its G-protein coupled receptor, the growth hormone secretagogue receptor (GHSR).
Prins K, Mutsters N, Volker F, Huisman M, Mies R, Delhanty PJD, Visser JA.   +6 more
europepmc   +5 more sources

Ghrelin receptors in non-mammalian vertebrates [PDF]

Frontiers in Endocrinology, 2013
The growth hormone secretagogue-receptor (GHS-R) was discovered in humans and pigs in 1996. The endogenous ligand, ghrelin, was discovered three years later, in 1999, and our understanding of the physiological significance of the ghrelin system in ...
Hiroyuki eKaiya, Kenji eKangawa, Mikiya eMiyazato   +2 more
doaj   +3 more sources

Intracerebroventricular urocortin 3 counteracts central acyl ghrelin-induced hyperphagic and gastroprokinetic effects via CRF receptor 2 in rats

Drug Design, Development and Therapy, 2016
Chun Yeh,1 Ching-Heng Ting,2 Ming-Luen Doong,3 Chin-Wen Chi,4,5 Shou-Dong Lee,1 Chih-Yen Chen6–8 1Division of Gastroenterology, Department of Internal Medicine, Cheng-Hsin General Hospital, 2Department of Pathology, Mackay Memorial Hospital ...
Yeh C, Ting CH, Doong ML, Chi CW, Lee SD, Chen CY   +5 more
doaj   +1 more source

LEAP-2: An Emerging Endogenous Ghrelin Receptor Antagonist in the Pathophysiology of Obesity. [PDF]

Front Endocrinol (Lausanne), 2021
Liver-expressed antimicrobial peptide 2 (LEAP-2), originally described as an antimicrobial peptide, has recently been recognized as an endogenous blocker of growth hormone secretagogue receptor 1a (GHS-R1a).
Lu X, Huang L, Huang Z, Feng D, Clark RJ, Chen C.   +5 more
europepmc   +2 more sources

Central functions of the ghrelin receptor

, 2014
The Ghrelin receptor was identified before its natural ligand ghrelin. This receptor is found both centrally and peripherally, and has been shown to affect various processes, such as food intake, gut motility, memory, glucose and lipid metabolism ...
Portelli, Jeanelle, Smolders, Ilse
core   +4 more sources

Effect of Bacterial Infection on Ghrelin Receptor Regulation in Periodontal Cells and Tissues. [PDF]

Int J Mol Sci, 2022
The effect of bacterial infection on the expression of growth hormone secretagogue receptor (GHS-R) was investigated in periodontal cells and tissues, and the actions of ghrelin were evaluated.
Nogueira AVB, Nokhbehsaim M, Damanaki A, Eick S, Beisel-Memmert S, Kirschneck C, Schröder A, Cirelli T, Leguizamón NDP, Cirelli JA, Deschner J.   +10 more
europepmc   +3 more sources

Ghrelin and ghrelin receptor modulation of psychostimulant action [PDF]

Frontiers in Neuroscience, 2013
Ghrelin (GHR) is an orexigenic gut peptide that modulates multiple homeostatic functions including gastric emptying, anxiety, stress, memory, feeding, and reinforcement. GHR is known to bind and activate growth-hormone secretagogue receptors (termed GHR-Rs).
Wellman, Paul J., Clifford, P. Shane, Rodriguez, Juan A.   +2 more
openaire   +3 more sources

MOLECULAR EVOLUTION OF GPCRS: Ghrelin/ghrelin receptors [PDF]

Journal of Molecular Endocrinology, 2013
After the discovery in 1996 of the GH secretagogue-receptor type-1a (GHS-R1a) as an orphan G-protein coupled receptor, many research groups attempted to identify the endogenous ligand. Finally, Kojima and colleagues successfully isolated the peptide ligand from rat stomach extracts, determined its structure, and named it ghrelin.
Hiroyuki, Kaiya, Kenji, Kangawa, Mikiya, Miyazato   +2 more
openaire   +2 more sources

The structure and function of the human ghrelin receptor [PDF]

, 2011
The peptide hormone, ghrelin, exerts its physiological effects through a G-protein-coupled receptor called the ghrelin-R. The ghrelin-R displays a high degree of constitutive activity, signalling through the inositol phosphate pathway in the absence of ...
Kendrick, Rachel
core   +7 more sources