The orexigenic effect of ghrelin is mediated through central activation of the endogenous cannabinoid system [PDF]
, 2008 INTRODUCTION: Ghrelin and cannabinoids stimulate appetite, this effect possibly being mediated by the activation of hypothalamic AMP-activated protein kinase (AMPK), a key enzyme in appetite and metabolism regulation. The cannabinoid receptor type 1 (CB1)
Judith Harvey-White +59 more
core +3 more sources
Ghrelin attenuates the osteoblastic differentiation of vascular smooth muscle cells through the ERK pathway. [PDF]
PLoS ONE, 2012 Vascular calcification results from osteoblastic differentiation of vascular smooth muscle cells (VSMCs) and is a major risk factor for cardiovascular events. Ghrelin is a newly discovered bioactive peptide that acts as a natural endogenous ligand of the
Qiu-Hua Liang +12 more
doaj +1 more source
Motilin Stimulates Gastric Acid Secretion in Coordination with Ghrelin in Suncus murinus. [PDF]
PLoS ONE, 2015 Motilin and ghrelin constitute a peptide family, and these hormones are important for the regulation of gastrointestinal motility. In this study, we examined the effect of motilin and ghrelin on gastric acid secretion in anesthetized suncus (house musk ...
Chayon Goswami +7 more
doaj +1 more source
The GOAT-ghrelin system is not essential for hypoglycemia prevention during prolonged calorie restriction. [PDF]
, 2012 Ghrelin acylation by ghrelin O-acyltransferase (GOAT) has recently been reported to be essential for the prevention of hypoglycemia during prolonged negative energy balance.
Bidlingmaier, Martin +104 more
core +2 more sources
Expression of adipokine ghrelin and ghrelin receptor in human colorectal adenoma and correlation with the grade of dysplasia. [PDF]
World J Gastrointest Surg, 2021 Background: Ghrelin is an adipokine that plays an important role in energy balance. Expression of ghrelin and ghrelin receptor has been investigated in different tissues and tumors.
Stojsavljevic-Shapeski S +9 more
europepmc +2 more sources
Expression of Ghrelin and Its Receptor mRNA in Bovine Oocyte and Cumulus Cells [PDF]
International Journal of Fertility and Sterility, 2019 Energy balance is regulated by ghrelin which is a neuroendocrine modulator. Ghrelin is expressed in repro- ductive organs. However, the role of ghrelin during in vitro maturation (IVM) and bovine preimplantational development is limited. The purpose of
Matías Angel Sirini +5 more
doaj +1 more source
NPY Receptors Blockade Prevents Anticonvulsant Action of Ghrelin in the Hippocampus of Rat [PDF]
Advanced Pharmaceutical Bulletin, 2013 Purpose: Ghrelin has been shown to have antiepileptic function. However, the underlying mechanisms by which, ghrelin exerts its antiepileptic effects are still unclear.
Mina Ghahramanian Golzar +5 more
doaj +1 more source
Frontiers in Nutrition, 2015 The gastrointestinal peptide hormone ghrelin is the endogenous ligand of the growth hormone secretagogue receptor (GHSR, a.k.a. ghrelin receptor, GHR). Currently, ghrelin is the only circulating peripheral hormone with the ability to promote a positive ...
Katrin eFischer +5 more
doaj +1 more source
Immunization against active ghrelin using virus-like particles for obesity treatment. [PDF]
, 2013 Ghrelin is a gut hormone that stimulates food intake. In physiological conditions, ghrelin plasma levels rise with fasting and decrease after meals. Obese individuals have low fasting ghrelin levels that rise after food restriction, which is pointed out ...
Carreira, Marcos +6 more
core +1 more source
A role of ghrelin in canine mammary carcinoma cells proliferation, apoptosis and migration
BMC Veterinary Research, 2012 Background Ghrelin is a natural ligand of the growth hormone secretagogue receptor (GHS-R). They are often co-expressed in multiple human tumors and related cancer cell lines what can indicate that the ghrelin/GHS-R axis may have an important role in ...
Majchrzak Kinga +6 more
doaj +1 more source