Results 41 to 50 of about 1,268,458 (245)

Recent Advances in Potential Clinical Application of Ghrelin in Obesity

Journal of Obesity, 2012
Ghrelin is the natural ligand of the growth hormone secretagogue receptor (GHS-R1a). Ghrelin is a 28 amino acid peptide possessing a unique acylation on the serine in position 3 catalyzed by ghrelin O-acyltransferase (GOAT).
Christine Delporte
doaj   +1 more source

Ghrelin accelerates growth of olfactory ensheathing cells through ERK pathway

Indian Journal of Animal Sciences, 2016
Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor (GHSR), stimulates growth hormone (GH) secretion and has both orexigenic and adipogenic effects.
PEI ZHANG, L I RUIFENG, L V HUICHENG, YANXIANG TONG, ZHIQIANG CHANG, Y U BAOLONG, W U YIMIN   +6 more
doaj   +1 more source

Ghrelin receptor in GtoPdb v.2021.3 [PDF]

, 2021
The ghrelin receptor (nomenclature as agreed by the NC-IUPHAR Subcommittee for the Ghrelin receptor [19]) is activated by a 28 amino-acid peptide originally isolated from rat stomach, where it is cleaved from a 117 amino-acid precursor (GHRL, Q9UBU3 ...
Holst, Birgitte, Maguire, Janet J., Davenport, Anthony P., Kleinz, Matthias, Sivertsen, Bjørn B.   +4 more
core   +1 more source

Influence of netball-based exercise on energy intake, subjective appetite and plasma acylated ghrelin in adolescent girls [PDF]

, 2013
This study explored 5-d regulation of exercise-induced energy expenditure, energy intake, and hormonal appetite, via acylated ghrelin, after acute exercise. Using a randomized crossover design, 10 female adolescents (13-15 y) completed two 7-d treatment
Stevenson, Emma, Stensel, D.J., Rumbold, P.L.S., Stensel, David, Dodd-Reynolds, C.J., Rumbold, Penny, Reynolds, Caroline, King, J.A., St Clair Gibson, Alan, King, J., Stensel, D., St Clair Gibson, A., King, James, Stevenson, E., Stevenson, E.J.   +14 more
core   +1 more source

GABAB Receptor Blockade Prevents Antiepileptic Action of Ghrelin in the Rat Hippocampus [PDF]

Advanced Pharmaceutical Bulletin, 2013
Purpose: Ghrelin has been shown to have antiepileptic function. However, the underlying mechanisms by which, ghrelin exerts its antiepileptic effects are still unclear.
Zohreh Ataie, Shirin Babri, Mina Ghahramanian Golzar, Hadi Ebrahimi, Fariba Mirzaie, Gisou Mohaddes   +5 more
doaj   +1 more source

Function of ghrelin and ghrelin receptors in the network regulation of gastric motility

Molecular Medicine Reports, 2014
Numerous previous studies have demonstrated that ghrelin promotes gastric motility when administered peripherally. This effect appears to be regulatory but not directly stimulatory, and therefore may involve a number of complex mechanisms. In the periphery, ghrelin may affect gastric motility through intercellular networks among interstitial cells of ...
Cheng-Guang, Yang, Zuo-Fu, Liao, Wen-Cai, Qiu, Jun, Yan, Zhi-Gang, Wang   +4 more
openaire   +3 more sources

Novel and Conventional Receptors for Ghrelin, Desacyl-Ghrelin, and Pharmacologically Related Compounds [PDF]

Pharmacological Reviews, 2014
The only molecularly identified ghrelin receptor is the growth hormone secretagogue receptor GHSR1a. Its natural ligand, ghrelin, is an acylated peptide whose unacylated counterpart (UAG) is almost inactive at GHSR1a. A truncated, nonfunctional receptor, GHSR1b, derives from the same gene.
Callaghan, B, Furness, JB
openaire   +3 more sources

The effects of diet and chronic exercise on skeletal muscle ghrelin response

Metabolism Open, 2022
Background: Recent findings indicate that ghrelin, particularly the unacylated form (UnAG), acutely stimulates skeletal muscle fatty acid oxidation (FAO) and can preserve insulin signaling and insulin-stimulated glucose uptake in the presence of high ...
Andrew J. Lovell, Evan M. Hoecht, Barbora Hucik, Daniel T. Cervone, David J. Dyck   +4 more
doaj   +1 more source

Multiple roles of ghrelin in breast cancer

The International Journal of Biological Markers, 2022
Breast cancer is one of the most threatening malignant tumors in women worldwide; hence, investigators are continually performing novel research in this field. However, an accurate prediction of its prognosis and postoperative recovery remains difficult.
Yiding Chen, Xuke Han, Lan Wang, Qing Wen, Liufu Li, Lisha Sun, Qiu Chen   +6 more
doaj   +1 more source

Gonadotropin‐Inhibitory Hormone (GnIH) and Its Receptor GPR147 Mediates Acute Stress‐Induced Activation of the Locus Coeruleus‐SAM Axis

Advanced Science, EarlyView.
ABSTRACT Gonadotropin‐inhibitory hormone (GnIH, also known as RFamide‐related peptide‐3, RFRP‐3) is a hypothalamic neuropeptide that regulates vertebrate reproduction via its receptor GPR147. Although GnIH is known to mediate stress‐induced reproductive suppression, its role in broader stress responses remains unclear.
Jiani Zhang, Hongyu Zhu, Wenqi Wang, Bingqian Shen, Yuanyuan Xin, Xingxing Song, Xuanyi Lu, Lixuan Li, Siting Chen, Xiaochen Zhang, Jialing Zeng, Haodong Zheng, Jianlong Lao, Ke Peng, Yixian Wei, Jiaming Zheng, Chuanhuo Hu, Xiaoye Wang, Xun Li   +18 more
wiley   +1 more source