Results 41 to 50 of about 20,015 (204)

Ghrelin in the human myometrium

Reproductive Biology and Endocrinology, 2010
Background Ghrelin is a 28-amino acid octanolyated peptide, synthesised primarily in the stomach. It stimulates growth hormone release, food intake and exhibits many other diverse effects. Our group have previously determined that ghrelin inhibited human
Morrison John J, Earley Padraig, O'Brien Margaret, Smith Terry J   +3 more
doaj   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

Evidence map and gap analysis of metabolic change in pediatric growth hormone deficiency treated with growth hormone

Pediatric Investigation, EarlyView.
This evidence map of 63 studies (n = 6158) showed growth hormone therapy in children with growth hormone deficiency has neutral glucose effects, mixed lipid outcomes, potential benefits for bone mineral density, bone mineral content, and parathyroid hormone, but generally no impact on thyroid function, body composition, or body mass index.
Wei Wu, Ningyi Song, Yue Zhao, Caiqi Du, Yuning Zhao, You Wu, Xiaoping Luo   +6 more
wiley   +1 more source

Ghrelin receptor deficiency does not affect diet-induced atherosclerosis in low-density lipoprotein receptor-null mice

Frontiers in Endocrinology, 2011
Objective: Ghrelin, a stomach-derived, secreted peptide, and its receptor (growth hormone secretagogue receptor, GHSR) are known to modulate food intake and energy homeostasis. The ghrelin system is also expressed broadly in cardiovascular tissues. Since
Kirk M. Habegger, Erin eGrant, Paul Thomas Pfluger, Diego ePerez-Tilve, Alan eDaugherty, Dennis eBruemmer, Matthias H Tschoep, Matthias H Tschoep, Susanna eHofmann, Susanna eHofmann   +9 more
doaj   +1 more source

Neonatal overfeeding disrupts pituitary ghrelin signalling in female rats long-term; Implications for the stress response. [PDF]

PLoS ONE, 2017
The hypothalamic-pituitary-adrenal (HPA) axis responses to psychological stress are exacerbated in adult female but not male rats made obese due to overfeeding in early life.
Luba Sominsky, Ilvana Ziko, Sarah J Spencer   +2 more
doaj   +1 more source

Sodium Ions Affect GPR17 Conformational States and Functionality

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Sodium is an allosteric modulator of several class‐A GPCR regulating active versus inactive conformation state and may be a critical issue for the optimization of crystallization procedures. Herein, the role of Na+ in the regulation of GPR17 conformational states was studied through MD simulations of GPR17 wild‐type and mutated on two ...
Luca Palazzolo, Simona Daniele, Davide Bianchi, Lara Russo, Stefano Capaldi, Maria Letizia Trincavelli, Ivano Eberini   +6 more
wiley   +1 more source

Using programmable infusion pump in avian species – a validation methodology in geese

Wildlife Biology, EarlyView.
Wildlife face anthropogenic and natural stressors that affect their physiology and behaviour. The activity of the hypothalamic–pituitary–adrenal axis and glucocorticoid (GC) production is intrinsically linked with energy regulation and environmental stressors.
Myriam Trottier‐Paquet, Maude Gauthier‐Bouchard, Akiko Kato, Charline Parenteau, Frédéric Angelier, Pierre Legagneux   +5 more
wiley   +1 more source

Taking Two to Tango: A Role for Ghrelin Receptor Heterodimerization in Stress and Reward

Frontiers in Neuroscience, 2013
The gut hormone, ghrelin, is the only known peripherally derived orexigenic signal. It activates its centrally expressed receptor, the growth hormone secretagogue receptor (GHS-R1a), to stimulate food intake.
Harriet eSchellekens, Timothy G Dinan, Timothy G Dinan, Timothy G Dinan, John F Cryan, John F Cryan, John F Cryan   +6 more
doaj   +1 more source

Impact of bariatric surgery on alcohol‐use disorder and alcohol‐related liver disease: A retrospective study

Addiction, EarlyView.
Abstract Background and aims Increased risk of alcohol dependence is recognised following bariatric surgery. Modified gastrointestinal anatomy and neurohormonal profiles lead to altered alcohol metabolism, peak blood alcohol concentrations and enhanced reward circuits and cravings.
Thomas J. Williams, Andrew J. Palmer, Jason P. Connor, Gerald Holtmann, Paul J. Clark   +4 more
wiley   +1 more source

In Situ Localization and Rhythmic Expression of Ghrelin and ghs-r1 Ghrelin Receptor in the Brain and Gastrointestinal Tract of Goldfish (Carassius auratus). [PDF]

PLoS ONE, 2015
Ghrelin is a gut-brain peptide hormone, which binds to the growth hormone secretagogue receptor (GHS-R) to regulate a wide variety of biological processes in fish.
Aída Sánchez-Bretaño, Ayelén M Blanco, Suraj Unniappan, Olivier Kah, Marie-M Gueguen, Juan I Bertucci, Ángel L Alonso-Gómez, Ana I Valenciano, Esther Isorna, María J Delgado   +9 more
doaj   +1 more source