Results 51 to 60 of about 20,015 (204)

Relationship of Ghrelin and Ghrelin Receptor Polymorphisms with Type 2 Diabetes

, 2022
There is compelling evidence that the gastric peptide ghrelin and its growth hormone secretagogue G protein-coupled receptor play an important role in glucose metabolism and energy homeostasis. Therefore, these genes carrying susceptibility alleles for Type 2 diabetes are considered as potential candidates.A case-control cross-sectional association ...
Özkahraman, Didem, Selçuk, Esma, Şahin Calapoğlu, Nilüfer, Calapoğlu, Mustafa, Şahin, Uğur   +4 more
openaire   +3 more sources

Gut microbiota as a novel therapeutic target for eating disorders and obesity

British Journal of Pharmacology, EarlyView.
The graphical abstract highlights the bidirectional interaction between the gut microbiota and central homeostatic and hedonic mechanisms regulating food intake, which contributes to overweight and obesity. It also illustrates emerging microbiota‐based biomarkers and therapeutic strategies (including prebiotics, probiotics, postbiotics, synbiotics and ...
Solveiga Samulėnaitė, Victor Mathis, Emmanuel Darcq, Aurelijus Burokas, Elena Martín‐García, Rafael Maldonado   +5 more
wiley   +1 more source

Therapeutic access points: The roles of circumventricular organs in drug delivery and metabolic regulation

British Journal of Pharmacology, EarlyView.
The current obesity drug landscape, dominated by GLP‐1 receptor agonists and emerging multi‐agonist therapies, has reinforced that long‐term weight loss is achieved in large part through central mechanisms that suppress appetite and reshape energy balance.
Ines Martinez‐Corral, Nicholas Monaco, Daniel I. Brierley, Monica Imbernon   +3 more
wiley   +1 more source

Preliminary investigation of ghrelin in horses and ponies: receptor expression and associations with prandial state, morphometry and signalment

BMC Veterinary Research
The hormone ghrelin has had limited attention in Equidae, despite connections with appetite and metabolic health in other species. Ghrelin influences hunger and food intake, energy expenditure and storage, glucose metabolism, and thermoregulation ...
Kate E. Andrews, Hayden L. Smith, Robert J. Spence, Martin N. Sillence, Melody A. de Laat   +4 more
doaj   +1 more source

Central neuropeptide Y receptors are involved in 3^rd ventricular ghrelin induced alteration of colonic transit time in conscious fed rats

BMC Gastroenterology, 2005
Background Feeding related peptides have been shown to be additionally involved in the central autonomic control of gastrointestinal functions. Recent studies have shown that ghrelin, a stomach-derived orexigenic peptide, is involved in the autonomic ...
Ritter Michael, Mronga Silke, Tebbe Clemens G, Tebbe Johannes J, Schäfer Martin KH   +4 more
doaj   +1 more source

Ghrelin indirectly activates hypophysiotropic CRF neurons in rodents. [PDF]

PLoS ONE, 2012
Ghrelin is a stomach-derived hormone that regulates food intake and neuroendocrine function by acting on its receptor, GHSR (Growth Hormone Secretagogue Receptor). Recent evidence indicates that a key function of ghrelin is to signal stress to the brain.
Agustina Cabral, Olga Suescun, Jeffrey M Zigman, Mario Perello   +3 more
doaj   +1 more source

Changes in gastrointestinal motility and gut hormone secretion after Roux‐en‐Y gastric bypass and sleeve gastrectomy for individuals with severe obesity

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Background Bariatric surgery is very effective in long‐term weight management. The present study was undertaken to investigate the short‐term effects of sleeve gastrectomy (SG) and of Roux‐en‐Y gastric bypass (RYGB) on (a) gastrointestinal (GI) motility, that is gastric emptying and oro‐cecal transit time and (b) secretion of regulatory gut ...
Jennifer A. Wilbrink, Mark van Avesaat, Simon W. Nienhuijs, Arnold Stronkhorst, Ad A. M. Masclee   +4 more
wiley   +1 more source

Influence of ghrelin on rat pituitary GH3 cell line proliferation

Journal of Medical Science, 2016
Introduction. Human ghrelin is the endogenous ligand of the growth hormone secretagogue receptor type 1a (GHSR1a). It is suggested that ghrelin is involved in pituitary adenomas pathogenesis. There are inconsistent data regarding the effect of ghrelin on
Małgorzata Chmielewska, Mirosław Andrusiewicz, Aleksandra Żbikowska, Katarzyna Kątniak, Agnieszka Sadowska, Grażyna Arasimowicz-Banaszak, Sławomir Graczyk, Ryszard Waśko, Malgorzata Kotwicka   +8 more
doaj   +1 more source

Glucocorticoids and HPA axis regulation in the stress–obesity connection: A comprehensive overview of biological, physiological and behavioural dimensions

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Chronic stress, characterized by increased long‐term exposure to the glucocorticoid hormone cortisol, is increasingly linked to obesity development. Still, various knowledge gaps persist, including on underlying pathophysiological mechanisms. The aim of the current review is to provide the latest insights on the connection between stress and ...
Robin Lengton, Myrte Schoenmakers, Brenda W. J. H. Penninx, Mariëtte R. Boon, Elisabeth F. C. van Rossum   +4 more
wiley   +1 more source

Expression of ghrelin and ghrelin functional receptor GHSR1a in human pituitary adenomas

Polish Archives of Internal Medicine, 2017
INTRODUCTION    Pituitary adenomas are heterogenous lesions commonly observed in the central nervous system. Signal transduction of ghrelin, an endogenous ligand specific for growth hormone secretagogue receptor (GHSR), has been reported to be involved in the development of endocrine tumors.
Mirosław, Andrusiewicz, Hanna, Komarowska, Izabela, Skibińska, Małgorzata, Chmielewska, Magdalena, Jaskuła-Świtek, Włodzimierz, Liebert, Ryszard, Waśko, Małgorzata, Kotwicka   +7 more
openaire   +2 more sources