Results 21 to 30 of about 6,435 (196)

Ghrelin Modulates Physiologic and Pathologic Retinal Angiogenesis through GHSR-1a [PDF]

Investigative Opthalmology & Visual Science, 2011
Vascular degeneration and the ensuing abnormal vascular proliferation are central to proliferative retinopathies. Given the metabolic discordance associated with these diseases, the authors explored the role of ghrelin and its growth hormone secretagogue receptor 1a (GHSR-1a) in proliferative retinopathy.In a rat model of oxygen-induced retinopathy ...
Zaniolo, Karine, Sapieha, Przemyslaw, Shao, Zhuo, Stahl, Andreas, Zhu, Tang, Tremblay, Sophie, Picard, Emilie, Madaan, Ankush, Blais, Martine, Lachapelle, Pierre, Mancini, Joseph, Hardy, Pierre, Smith, Lois E. H., Ong, Huy, Chemtob, Sylvain   +14 more
openaire   +6 more sources

GHSR‐Foxo1 Signaling in Macrophages Promotes Liver Fibrosis via Inflammatory Response and Hepatic Stellate Cell Activation

Advanced Science
Liver fibrosis is a severe liver disease directly linked to chronic inflammation, in which hepatic macrophages play a key role. Growth hormone secretagogue receptor (GHSR) is the receptor of nutrient‐sensing hormone ghrelin that has essential functions ...
Da Mi Kim, Quan Pan, Zeyu Liu, Weiqi Ai, Hye Won Han, Sakhila K. Banu, Robert Y.L. Tsai, Gus A. Wright, Shaodong Guo, Yuxiang Sun   +9 more
doaj   +2 more sources

Genetic or pharmacological GHSR blockade has sexually dimorphic effects in rodents on a high-fat diet

Communications Biology
The stomach-derived hormone ghrelin regulates essential physiological functions. The ghrelin receptor (GHSR) has ligand-independent actions; therefore, GHSR gene deletion may be a reasonable approach to investigate the role of this system in feeding ...
András H. Lékó, Adriana Gregory-Flores, Renata C. N. Marchette, Juan L. Gomez, Janaina C. M. Vendruscolo, Vez Repunte-Canonigo, Vicky Choung, Sara L. Deschaine, Kimberly E. Whiting, Shelley N. Jackson, Maria Paula Cornejo, Mario Perello, Zhi-Bing You, Michael Eckhaus, Karuna Rasineni, Kim D. Janda, Barry Zorman, Pavel Sumazin, George F. Koob, Michael Michaelides, Pietro P. Sanna, Leandro F. Vendruscolo, Lorenzo Leggio   +22 more
doaj   +2 more sources

Detection of recurrent endometrial cancer via DNA methylation analysis of cervicovaginal self‐samples and urine [PDF]

International Journal of Cancer, Volume 158, Issue 9, Page 2491-2500, 1 May 2026.
What's new? Post‐treatment surveillance for endometrial cancer aims to detect recurrence early, potentially improving outcome. Emerging evidence suggests that DNA methylation analysis of self‐collected cervicovaginal and urine samples is a promising approach.
Annick J. Nouwens, Mirte Schaafsma, Nienke E. van Trommel, Jenneke C. Kasius, Renske D. M. Steenbergen, Maaike C. G. Bleeker   +5 more
wiley   +2 more sources

Investigation of GHSR methylation levels in thymomas from patients with Myasthenia Gravis

Gene, 2020
Hypermethylation of the growth hormone secretagogue receptor gene (GHSR) is increasingly observed in human cancers, suggesting that it could represent a pan-cancer biomarker of clinical interest. However, little is still known concerning GHSR methylation levels in thymic epithelial tumors, and particularly in thymomas from patients with Myasthenia ...
Coppede F., Stoccoro A., Nicoli V., Gallo R., De Rosa A., Guida M., Maestri M., Lucchi M., Ricciardi R., Migliore L.   +9 more
openaire   +4 more sources

Mutations in the ghrelin receptor gene GHSR in congenital hypopituitarism

Problems of Endocrinology, 2017
The results of molecular genetic studies indicate the potential involvement of ghrelin in the pathogenesis of some dwarfism forms. However, in the case of isolated somatotropin insufficiency, mutations in the ghrelin receptor gene are a rare cause of the disease.
Elena B. Bashnina, Olga S. Berseneva, Andrey S. Glotov, Oleg S. Glotov, Mariia E. Turkunova, Elena A. Serebryakova, Vladislav S. Baranov   +6 more
openaire   +3 more sources

Neuronal ablation of GHSR mitigates diet-induced depression and memory impairment via AMPK-autophagy signaling-mediated inflammation [PDF]

Frontiers in Immunology
Obesity is associated with chronic inflammation in the central nervous system (CNS), and neuroinflammation has been shown to have detrimental effects on mood and cognition.
Hongying Wang, Hongying Wang, Zheng Shen, Chia-Shan Wu, Pengfei Ji, Ji Yeon Noh, Cédric G. Geoffroy, Sunja Kim, David Threadgill, David Threadgill, David Threadgill, Jianrong Li, Yu Zhou, Xiaoqiu Xiao, Hui Zheng, Yuxiang Sun   +15 more
doaj   +2 more sources

Functional characterisation of obesity-associated MRAP2 variants on MC4R and GHSR signalling. [PDF]

Hum Mol Genet
Abstract Melanocortin-2 receptor accessory protein-2 (MRAP2) modulates the activity of hypothalamic melanocortin-4 (MC4R) and growth hormone-secretagogue (GHSR) receptors, which suppress and promote appetite, respectively. We investigate whether obesity-associated variants of MRAP2 alter their ability to modulate MC4R and GHSR ...
Rodríguez Rondón AV, Prins K, Volker F, van der Walle EEPL, de Groot CJ, van der Akker ELT, van Rossum EFC, van Haelst MM, Delhanty PJD, Visser JA.   +9 more
europepmc   +3 more sources

Loss-of-Function GHSR Variants Are Associated With Short Stature and Low IGF-I [PDF]

The Journal of Clinical Endocrinology & Metabolism
Abstract Context The growth hormone (GH) secretagogue receptor, encoded by GHSR, is expressed on somatotrophs of the pituitary gland. Stimulation with its ligand ghrelin, as well as its constitutive activity, enhances GH secretion. Studies in knockout mice suggest that heterozygous loss-of-function of
Lauren D Punt, Sander Kooijman, Noa J M Mutsters, Kaiming Yue, Daniëlle C M van der Kaay, Vera van Tellingen, Willie M Bakker-van Waarde, Annemiek M Boot, Erica L T van den Akker, Anneke A van Boekholt, Kirsten de Groote, Anne R Kruijsen, Nancy H G van Nieuwaal-van Maren, M Claire Woltering, Malou Heijligers, Josine C van der Heyden, Ellen M N Bannink, Tuula Rinne, Sabine E Hannema, Wouter J de Waal, Lucia C Delemarre, Patrick C N Rensen, Christiaan de Bruin, Hermine A van Duyvenvoorde, Jenny A Visser, Patric J D Delhanty, Monique Losekoot, Jan M Wit, Sjoerd D Joustra   +28 more
openaire   +8 more sources

Ghrelin-GHSR-LEAP2 system in the pathophysiology of type 2 diabetes. [PDF]

iScience
The Ghrelin-GHSR-LEAP2 system plays a multifaceted role in the pathophysiology of type 2 diabetes mellitus (T2DM). Ghrelin, through the activation of its receptor GHS-R1a, contributes to hyperglycemia by suppressing insulin secretion, inducing insulin resistance, and promoting hepatic glucose production. In contrast, LEAP2, an endogenous antagonist and
Pu Y, Yang J, Li W, Wen Y, Zheng C, Li Y, Wu L, Ming Y, Zhao C, Chen C.   +9 more
europepmc   +6 more sources