Results 21 to 30 of about 5,420 (161)

Mechanistic Investigation of GHS-R Mediated Glucose-Stimulated Insulin Secretion in Pancreatic Islets

Biomolecules, 2022
Ghrelin receptor, a growth hormone secretagogue receptor (GHS-R), is expressed in the pancreas. Emerging evidence indicates that GHS-R is involved in the regulation of glucose-stimulated insulin secretion (GSIS), but the mechanism by which GHS-R ...
Geetali Pradhan, Jong Han Lee, Chia-Shan Wu, Hongying Wang, Ligen Lin, Taraka Donti, Brett H. Graham, Arun S. Rajan, Ashok Balasubramanyam, Susan L. Samson, Shaodong Guo, Yuxiang Sun   +11 more
doaj   +1 more source

Regional Differences in the Ghrelin-Growth Hormone Secretagogue Receptor Signalling System in Human Heart Disease

CJC Open, 2021
Background: The hormone ghrelin and its receptor, the growth hormone secretagogue receptor (GHSR) are expressed in myocardium. GHSR binding activates signalling pathways coupled to cardiomyocyte survival and contractility.
Rebecca Sullivan, BSc, Varinder K. Randhawa, PhD, MD, Tyler Lalonde, PhD, Tina Yu, BSc, Bob Kiaii, MD, Leonard Luyt, PhD, Gerald Wisenberg, MD, Savita Dhanvantari, PhD   +7 more
doaj   +1 more source

Depending on GHSR [PDF]

Science-Business eXchange, 2009
Swedish researchers have used compounds from Aeterna Zentaris and Ipsen Group to develop evidence that ghrelin inhibition could treat alcohol dependence, if the receptor can be targeted without adversely affecting appetite or body weight.
openaire   +1 more source

Neuronal GHS-R Differentially Modulates Feeding Patterns under Normal and Obesogenic Conditions

Biomolecules, 2022
The orexigenic hormone ghrelin increases food intake and promotes obesity through its receptor, growth hormone secretagogue receptor (GHS-R). We previously reported two neuron-specific GHS-R knockout mouse lines, namely pan-neuronal deletion by Syn1-cre ...
Jong Han Lee, Bingzhong Xue, Zheng Chen, Yuxiang Sun   +3 more
doaj   +1 more source

The role of ghrelin-responsive mediobasal hypothalamic neurons in mediating feeding responses to fasting

Molecular Metabolism, 2017
Objective: Ghrelin is a stomach-derived hormone that affects food intake and regulates blood glucose. The best-characterized actions of ghrelin are mediated by its binding to and activation of the growth hormone secretagogue receptor (GHSR; ghrelin ...
Bharath K. Mani, Sherri Osborne-Lawrence, Mathieu Mequinion, Sydney Lawrence, Laurent Gautron, Zane B. Andrews, Jeffrey M. Zigman   +6 more
doaj   +1 more source

Disrupting the ghrelin-growth hormone axis limits ghrelin's orexigenic but not glucoregulatory actions

Molecular Metabolism, 2021
Objective: Acyl-ghrelin regulates eating, body weight, blood glucose, and GH secretion upon binding to its receptor GHSR (growth hormone secretagogue receptor; ghrelin receptor). GHSR is distributed in several brain regions and some peripheral cell-types
Deepali Gupta, Anna M. Patterson, Sherri Osborne-Lawrence, Angie L. Bookout, Salil Varshney, Kripa Shankar, Omprakash Singh, Nathan P. Metzger, Corine P. Richard, Steven C. Wyler, Joel K. Elmquist, Jeffrey M. Zigman   +11 more
doaj   +1 more source

Novel Long-Acting Ghrelin Analogue PEP-064 Restores Energy Balance in C26 and Lewis Lung Carcinoma-Induced cachexia in Mice. [PDF]

J Cachexia Sarcopenia Muscle
ABSTRACT Background Cancer cachexia is a debilitating syndrome marked by involuntary weight loss resulting from reduced food intake and intricate metabolic reprogramming. Despite its high prevalence, cancer cachexia remains undertreated, with a lack of effective and approved pharmacotherapies.
Hunt JE, Lund C, Chen B, Diaz AR, Dmytriyeva O, Marcotorchino J, Löbner K, Mörl K, Andersen NR, Ogueboule ZKJ, Frank E, Stöhr J, Meseguer D, Panajotova V, Roux J, Clemmensen C, Sylow L, Schneeberger M, Beck-Sickinger AG, Pedersen SL, Fosgerau K.   +20 more
europepmc   +2 more sources

GHS-R1a Deficiency Alleviates Depression-Related Behaviors After Chronic Social Defeat Stress

Frontiers in Neuroscience, 2019
Ghrelin is an important orexigenic hormone that regulates feeding, metabolism and glucose homeostasis in human and rodents. Ghrelin functions by binding to its receptor, the growth hormone secretagogue receptor 1a (GHS-R1a), which is widely expressed ...
Li Guo, Li Guo, Minglu Niu, Minglu Niu, Jie Yang, Jie Yang, Li Li, Shuhan Liu, Yuxiang Sun, Zhishang Zhou, Zhishang Zhou, Yu Zhou, Yu Zhou   +12 more
doaj   +1 more source

Ghrelin-GHSR-LEAP2 system in the pathophysiology of type 2 diabetes. [PDF]

iScience
The Ghrelin-GHSR-LEAP2 system plays a multifaceted role in the pathophysiology of type 2 diabetes mellitus (T2DM). Ghrelin, through the activation of its receptor GHS-R1a, contributes to hyperglycemia by suppressing insulin secretion, inducing insulin resistance, and promoting hepatic glucose production. In contrast, LEAP2, an endogenous antagonist and
Pu Y, Yang J, Li W, Wen Y, Zheng C, Li Y, Wu L, Ming Y, Zhao C, Chen C.   +9 more
europepmc   +6 more sources

Ghrelin/GHSR Axis Induced M2 Macrophage and Alleviated Intestinal Barrier Dysfunction in a Sepsis Rat Model by Inactivating E2F1/NF-κB Signaling

Canadian Journal of Gastroenterology and Hepatology, 2023
Sepsis is an inflammatory reaction disorder state that is induced by infection. The activation and regulation of the immune system play an essential role in the development of sepsis.
Lei Zhu, Zhimin Dou, Wei Wu, Qiliang Hou, Sen Wang, Ziqian Yuan, Bin Li, Jian Liu   +7 more
doaj   +1 more source