Results 31 to 40 of about 5,420 (161)

Familial partial lipodystrophy type 2 and obesity, two adipose tissue pathologies with different inflammatory profiles

Diabetology & Metabolic Syndrome, 2023
Introduction The transition to metabolically unhealthy obesity (MUO) is driven by the limited expandability of adipose tissue (AT). Familial Partial Lipodystrophy type 2 (FPLD2) is an alternative model for AT dysfunction that is suitable for comparison ...
Guillaume Treiber, Marie-Paule Gonthier, Alice Guilleux, Samir Medjane, Oriane Bonfanti, Muriel Cogne, Olivier Meilhac, Estelle Nobecourt   +7 more
doaj   +1 more source

Functional characterisation of obesity-associated MRAP2 variants on MC4R and GHSR signalling. [PDF]

Hum Mol Genet
Abstract Melanocortin-2 receptor accessory protein-2 (MRAP2) modulates the activity of hypothalamic melanocortin-4 (MC4R) and growth hormone-secretagogue (GHSR) receptors, which suppress and promote appetite, respectively. We investigate whether obesity-associated variants of MRAP2 alter their ability to modulate MC4R and GHSR ...
Rodríguez Rondón AV, Prins K, Volker F, van der Walle EEPL, de Groot CJ, van der Akker ELT, van Rossum EFC, van Haelst MM, Delhanty PJD, Visser JA.   +9 more
europepmc   +3 more sources

Genetic determination of the cellular basis of the ghrelin-dependent bone remodeling

Molecular Metabolism, 2015
Objective: Bone mass is maintained through a balance of bone formation and resorption. This homeostatic balance is regulated by various systems involving humoral and local factors.
Chengshan Ma, Toru Fukuda, Hiroki Ochi, Satoko Sunamura, Cheng Xu, Ren Xu, Atsushi Okawa, Shu Takeda   +7 more
doaj   +1 more source

The ghrelinergic system in zebrafish gonads is suppressed during food unavailability

Aquaculture and Fisheries, 2022
Ghrelin is an appetite stimulatory peptide that regulates reproduction in vertebrates. The acylation of ghrelin by ghrelin-O-acyltransferase (Goat) is essential for most of its functions. The ghrelinergic system (ghrelin, ghrelin receptor [Ghsr] and Goat)
Azadeh Hatef, Jithine Jayakumar Rajeswari, Suraj Unniappan   +2 more
doaj   +1 more source

GHSR deficiency suppresses neointimal formation in injured mouse arteries [PDF]

Biochemical and Biophysical Research Communications, 2016
Growth hormone secretagogue receptor (GHSR) is involved in appetite regulation and energy homeostasis. In the present study, we examined the role of GHSR in neointimal formation following vascular injury. In the mouse model of femoral artery wire injury, we found that vessel intima-to-media ratio was significantly reduced in GHSR deficiency (GHSR ...
Jing, Li, Man, Zhang, Mo, Wang, Zhipeng, Wang, Yahan, Liu, Weizhen, Zhang, Nanping, Wang   +6 more
openaire   +2 more sources

Association Analysis of the Leptin and Ghrelin Receptor Gene Polymorphism in the Human with BMI

Scientific Papers Animal Science and Biotechnologies, 2023
The aim of this work was identification of Leptin and Ghrelin receptor gene polymorphism in the population. Leptin is a product of obese (ob) gene expression that plays a role in energy metabolism and body weight.
Zuzana Lieskovská, Anna Trakovická, Anton Kováčik, Tomáš Minarovič, Alica Rafayová   +4 more
doaj  

Variations in the ghrelin receptor gene associate with obesity and glucose metabolism in individuals with impaired glucose tolerance. [PDF]

PLoS ONE, 2008
Ghrelin may influence the development of obesity through its role in the control of energy balance, food intake, and regulation of body weight. The effects of ghrelin are mediated via the growth hormone secretagogue receptor (GHSR).We genotyped 7 single ...
Ursula Mager, Tatjana Degenhardt, Leena Pulkkinen, Marjukka Kolehmainen, Anna-Maija Tolppanen, Jaana Lindström, Johan G Eriksson, Carsten Carlberg, Jaakko Tuomilehto, Matti Uusitupa, Finnish Diabetes Prevention Study Group   +10 more
doaj   +1 more source

Involvement of the GHSR in the developmental programming and metabolic disturbances induced by maternal undernutrition [PDF]

The Journal of Nutritional Biochemistry, 2020
The mismatch between maternal undernutrition and adequate nutrition after birth increases the risk of developing metabolic diseases. We aimed to investigate whether the hyperghrelinemia during maternal undernourishment rewires the hypothalamic development of the offspring and contributes to the conversion to an obese phenotype when fed a high-fat diet (
Sun, Shu, Corbeels, Katrien, Desmet, Louis, Segers, Anneleen, Wang, Qiaoling, Van der Schueren, Bart, Depoortere, Inge   +6 more
openaire   +3 more sources

Sodium is a negative allosteric regulator of the ghrelin receptor

Cell Reports, 2023
Summary: The functional properties of G protein-coupled receptors (GPCRs) are intimately associated with the different components in their cellular environment.
Guillaume Ferré, Antoniel A.S. Gomes, Maxime Louet, Marjorie Damian, Paulo M. Bisch, Olivier Saurel, Nicolas Floquet, Alain Milon, Jean-Louis Banères   +8 more
doaj   +1 more source

Family and population-based studies of variation within the ghrelin receptor locus in relation to measures of obesity. [PDF]

PLoS ONE, 2010
The growth hormone secretagogue receptor (GHSR) is mediating hunger sensation when stimulated by its natural ligand ghrelin. In the present study, we tested the hypothesis that common and rare variation in the GHSR locus are related to increased ...
Anette P Gjesing, Lesli H Larsen, Signe S Torekov, Irena Aldhoon Hainerová, Rahul Kapur, Anders Johansen, Anders Albrechtsen, Sylvia Boj, Birgitte Holst, Angela Harper, Søren A Urhammer, Knut Borch-Johnsen, Charlotta Pisinger, Søren M Echwald, Hans Eiberg, Arne Astrup, Jan Lebl, Jorge Ferrer, Thue W Schwartz, Torben Hansen, Oluf Pedersen   +20 more
doaj   +1 more source