Results 31 to 40 of about 6,435 (196)

GHSR-Targeted PET Imaging Probe. [PDF]

ACS Med Chem Lett
Song R, Liang SH.
europepmc   +2 more sources

GHSR suppression in neurons protects against aging-associated metabolic and cognitive impairments. [PDF]

Geroscience
Abstract Aging is accompanied by progressive declines in metabolic and cognitive functions. Growth hormone secretagogue receptor (GHSR), a receptor for the gut hormone ghrelin, is highly expressed in neurons and plays a crucial role in metabolic regulation.
Wang H, Wu CS, Landrock D, Nevarez A, Liu S, Thalacker-Mercer A, Zhang Y, Baum JI, Kim S, Xue B, Sun Y.   +10 more
europepmc   +3 more sources

Growth Hormone Secretagogue Receptor (GHSR) Is Elevated in Myocardial Tissues of DMD mdx:utrn^−/− Mice, and Correlates Strongly with Inflammatory Markers, and Negatively with Cardiac Function [PDF]

Cells
Dilated cardiomyopathy affects greater than 1 in 2500 patients worldwide, including those with the neuromuscular disorder Duchenne muscular dystrophy (DMD).
Maedeh Naghibosadat, Andrew McClennan, Margarita Egiian, Reema Flynn-Rizk, Tyler Lalonde, Carlie Charron, Anish Chhabra, Leonard G. Luyt, Savita Dhanvantari, Lisa M. Hoffman   +9 more
doaj   +2 more sources

GHSR hypermethylation: a promising pan-cancer marker [PDF]

Cell Cycle, 2015
The advent of high-throughput technologies such as microarrays, global gene knockout, and next generation sequencing (NGS) has revolutionized the field of molecular oncology. Large-scale endeavors of the kind represented by the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA) are generating comprehensive portraits of ...
Pouria, Jandaghi, Jörg D, Hoheisel, Yasser, Riazalhosseini   +2 more
openaire   +2 more sources

Depending on GHSR [PDF]

Science-Business eXchange, 2009
Swedish researchers have used compounds from Aeterna Zentaris and Ipsen Group to develop evidence that ghrelin inhibition could treat alcohol dependence, if the receptor can be targeted without adversely affecting appetite or body weight.
openaire   +1 more source

The GOAT-ghrelin system is not essential for hypoglycemia prevention during prolonged calorie restriction. [PDF]

, 2012
Ghrelin acylation by ghrelin O-acyltransferase (GOAT) has recently been reported to be essential for the prevention of hypoglycemia during prolonged negative energy balance.
Bidlingmaier, Martin, Stephen C Benoit, Kristy M. Heppner (182036), Tong, J., Pfluger, Paul T., Zhao, Y., Bidlingmaier, M., Davis, Harold W., Chun-Xia Yi (182031), Kirchner, H., Erin Bartley (182062), Tong, Jenny, Tschöp, Matthias H., Bartley, Erin, Kruthaupt Traci, Gaylinn, B.D., Kirchner, Henriette, Matthias H. Tschöp (158357), Kirk M Habegger, Yongmei Zhao (182070), Kabra, D.G., Bruce D Gaylinn, Timo D. Müller (103425), Stephen C. Benoit (179150), Heppner, K.M., Joseph Anupama, Heppner, Kristy M., Kabra, Dhiraj, Davis, H.W., Yi, Chun-Xia, Traci Kruthaupt (182079), Kristy M Heppner, Joseph, A., Habegger Kirk M., Ottaway, N., Benoit, S.C., Harold W. Davis (182066), Ottaway Nickki, Zhao Yongmei, Nickki Ottaway, Yi, C.-X., Bielohuby Maximillian, Joseph, Anupama, Müller, T.D., Jenny Tong (182043), Kruthaupt, Traci, Yi Chun-Xia, Perez-Tilve Diego, Yongmei Zhao, Maximillian Bielohuby (182048), Müller, Timo D., Davis Harold W., Kirk M. Habegger (182097), Tschöp Matthias H., Anupama Joseph (182074), Dhiraj Kabra (182091), Bidlingmaier Martin, Bartley, E., Thorner, Michael O., Maximillian Bielohuby, Harold W Davis, Nickki Ottaway (182086), Anupama Joseph, Matthias H Tschöp, Benoit, Stephen C., Diego Perez-Tilve, Gaylinn Bruce D., Müller Timo D., Dhiraj Kabra, Kirchner Henriette, Jenny Tong, Traci Kruthaupt, Gaylinn, Bruce D., Paul T Pfluger, Perez-Tilve, Diego, Michael O Thorner, Diego Perez-Tilve (182114), Zhao, Yongmei, Thorner Michael O., Bielohuby, M., Tschöp, M.H., Henriette Kirchner (182039), Kabra Dhiraj, Timo D Müller, Bartley Erin, Habegger, K.M., Bielohuby, Maximilian, Michael O. Thorner (182107), Paul T. Pfluger (179123), Martin Bidlingmaier (150187), Pfluger Paul T., Bruce D. Gaylinn (182057), Chun-Xia Yi, Martin Bidlingmaier, Habegger, Kirk M, Henriette Kirchner, Pfluger, P.T., Benoit Stephen C., Kruthaupt, T., Heppner Kristy M., Erin Bartley, Tong Jenny, Ottaway, Nickki, Perez-Tilve, D., Thorner, M.O.   +104 more
core   +2 more sources

The role of ghrelin-responsive mediobasal hypothalamic neurons in mediating feeding responses to fasting

Molecular Metabolism, 2017
Objective: Ghrelin is a stomach-derived hormone that affects food intake and regulates blood glucose. The best-characterized actions of ghrelin are mediated by its binding to and activation of the growth hormone secretagogue receptor (GHSR; ghrelin ...
Bharath K. Mani, Sherri Osborne-Lawrence, Mathieu Mequinion, Sydney Lawrence, Laurent Gautron, Zane B. Andrews, Jeffrey M. Zigman   +6 more
doaj   +1 more source

Discovery of a functionally selective ghrelin receptor (GHSR(1a)) ligand for modulating brain dopamine

, 2022
The growth hormone secretagogue receptor-1a (GHSR(1a)) is the cognate G protein–coupled receptor (GPCR) for the peptide hormone ghrelin. GHSR(1a) is a promising therapeutic target for a wide range of metabolic, age-related, and central nervous system ...
Clark, N., Gross, J. D., Marugan, J. J., Ray, C. R., Xu, X., Wetsel, W. C., Slosky, L. M., Barak, L. S., Toth, K., Jansen, D., Wang, A., Ferrer, M., Clark, N. B., Hu, X., Southall, N., Barnaeva, E., Caron, M. G., Caron, M. J., Kim, D. W., Zhou, Y.   +19 more
core   +1 more source

GHS-R1a Deficiency Alleviates Depression-Related Behaviors After Chronic Social Defeat Stress

Frontiers in Neuroscience, 2019
Ghrelin is an important orexigenic hormone that regulates feeding, metabolism and glucose homeostasis in human and rodents. Ghrelin functions by binding to its receptor, the growth hormone secretagogue receptor 1a (GHS-R1a), which is widely expressed ...
Li Guo, Li Guo, Minglu Niu, Minglu Niu, Jie Yang, Jie Yang, Li Li, Shuhan Liu, Yuxiang Sun, Zhishang Zhou, Zhishang Zhou, Yu Zhou, Yu Zhou   +12 more
doaj   +1 more source

Disrupting the ghrelin-growth hormone axis limits ghrelin's orexigenic but not glucoregulatory actions

Molecular Metabolism, 2021
Objective: Acyl-ghrelin regulates eating, body weight, blood glucose, and GH secretion upon binding to its receptor GHSR (growth hormone secretagogue receptor; ghrelin receptor). GHSR is distributed in several brain regions and some peripheral cell-types
Deepali Gupta, Anna M. Patterson, Sherri Osborne-Lawrence, Angie L. Bookout, Salil Varshney, Kripa Shankar, Omprakash Singh, Nathan P. Metzger, Corine P. Richard, Steven C. Wyler, Joel K. Elmquist, Jeffrey M. Zigman   +11 more
doaj   +1 more source