Results 51 to 60 of about 6,435 (196)
Frontiers in Pharmacology, 2023 Ghrelin, a stomach-derived orexigenic hormone, has a well-established role in energy homeostasis, food reward, and emotionality. Noradrenergic neurons of the locus coeruleus (LC) are known to play an important role in arousal, emotion, cognition, but ...
Ivana Maric +14 more
doaj +1 more source
Sodium Ions Affect GPR17 Conformational States and Functionality
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT Sodium is an allosteric modulator of several class‐A GPCR regulating active versus inactive conformation state and may be a critical issue for the optimization of crystallization procedures. Herein, the role of Na+ in the regulation of GPR17 conformational states was studied through MD simulations of GPR17 wild‐type and mutated on two ...
Luca Palazzolo +6 more
wiley +1 more source
An atomic look at the interface of GHSR and its partners
Computational and Structural Biotechnology JournalG protein-coupled receptors (GPCRs) regulate cellular activity by transducing external signals and selectively coupling them to intracellular partners. Ghrelin receptor (GHSR) has garnered significant interest over the past decade owing to its diverse functional roles.
Barreto, Carlos A.V., Moreira, Irina S.
openaire +2 more sources
, 2014 (A) The primers used for the genotyping in the PCR (left) and representative results of genotyping (right). The primers used are indicated as arrows. TBC, transcription blocking cassette. (B–J) The phenotype differences among the four experimental groups:
Hitoshi Minakuchi (586388) +12 more
core +1 more source
British Journal of Pharmacology, EarlyView.The current obesity drug landscape, dominated by GLP‐1 receptor agonists and emerging multi‐agonist therapies, has reinforced that long‐term weight loss is achieved in large part through central mechanisms that suppress appetite and reshape energy balance.
Ines Martinez‐Corral +3 more
wiley +1 more source
Economic Growth Vulnerability Across Euro Area Countries
Oxford Bulletin of Economics and Statistics, EarlyView.ABSTRACT We analyse growth vulnerability in the four largest Euro Area (EA) economies, measured as a lower quantile of the growth distribution conditional on EA‐wide and country‐specific macroeconomic/financial factors. Growth densities are obtained under a normal activity scenario and under stressed conditions.
Claudio Lissona, Esther Ruiz
wiley +1 more source
Ghrelin Receptor Is Required for the Effect of Nesfatin-1 on Glucose Metabolism
Frontiers in Endocrinology, 2018 Studies of nesfatin-1 in glucose metabolism have become a topic of interest recently, however, the specific receptor for nesfatin-1 has not yet been identified.
Xin-Tong Fan +11 more
doaj +1 more source
Smartphone based music intervention in the treatment of episodic migraine headaches – A pilot trial
Complementary Therapies in Medicine, 2021 Objectives: Migraine headaches are a prevalent and burdening disorder for the public worldwide. Both traditional preventive drugs and behavioral-based interventions have been used as treatment in the prevention of migraine attacks.
Guilhem Parlongue +3 more
doaj +1 more source
Ghrelin Drives Food Intake by Attentional Bias Toward Food Cues
Comprehensive Physiology, Volume 16, Issue 5, October 2026.Fasting and ghrelin enhanced engagement with food‐predictive cues in a home‐cage FED3 task, increasing correct and premature responses while reducing omissions. However, ghrelin preferentially increased food intake when food availability was signaled by a predictive cue, whereas fasting increased intake regardless of cue context.
Renée Poelman +6 more
wiley +1 more source
, 2022 The gastric hunger signal, ghrelin, influences feeding behavior via activation of the growth hormone secretagogue receptor (GHSR). GHSR's are abundantly expressed in cells in the ventral hippocampus (VHPC) where they function to regulate food intake.
Kondilis, Athanasios
core +1 more source