Results 51 to 60 of about 5,420 (161)

Alcohol Exposure Alters the Ghrelin System: In Vitro Mechanistic Insights Into Impaired Glucose Sensing and Enhanced Ghrelin Secretion

Alcohol, Clinical and Experimental Research, Volume 50, Issue 8, August 2026.
Chronic ethanol exposure increases ghrelin production by impairing glucose sensing in ghrelin‐secreting cells. Ethanol elevates ghrelin and ghrelin O‐acyltransferase expression, blunts glucose‐mediated suppression, and synergizes with fatty acids to enhance secretion.
Sundararajan Mahalingam, Ramesh Bellamkonda, Kusum K. Kharbanda, Ojeshvi Ethiraj, Carol A. Casey, Karuna Rasineni   +5 more
wiley   +1 more source

Altered responses to ghrelin and food cues in AgRP neurons during pregnancy and lactation

Journal of Neuroendocrinology, Volume 38, Issue 6, June 2026.
Abstract Pregnancy and lactation trigger many metabolic adaptations, including increased food intake to support the energy demands of the growing foetus and then to provide nutrition through milk production after birth. Ghrelin, an orexigenic hormone, activates agouti related peptide (AgRP) neurons in the arcuate nucleus to promote food intake.
C. L. Murrell, M. R. Perkinson, Z. B. Andrews, D. R. Grattan, S. R. Ladyman   +4 more
wiley   +1 more source

Associations of PYY, GLP‐1 and LEAP2 with changes in feeding‐related cognition, body weight and glucose homeostasis after bariatric surgery in non‐diabetic women

Journal of Neuroendocrinology, Volume 38, Issue 6, June 2026.
Abstract Roux‐en‐Y gastric bypass (RYGB) is an effective surgical intervention for severe obesity, but the role of gastrointestinal hormones in its benefits remains unclear. We examined longitudinal pre‐to‐post‐meal gastrointestinal hormone changes and their relationships with glucose homeostasis and feeding‐related cognitive responses in women ...
María F. Andreoli, Pablo N. De Francesco, Wei Zhou, Olga E. Titova, Ahmed Alsehli, Robert Fredriksson, Magnus Sundbom, Mario Perello, Helgi B. Schiöth   +8 more
wiley   +1 more source

Molecular cloning and expression characteristics of ghrl and ghsr genes in bighead carp (Hypophthalmichthys nobilis)

Aquaculture and Fisheries
Ghrelin (ghrl) and its receptor gene ghsr (growth hormone secretagogue receptor) regulate numerous physiological functions, including growth hormone secretion and food intake.
Pan Wang, Jianjun Fu, Mingkun Luo, Xiulan Shi, Wenbin Zhu, Lanmei Wang, Shichang Shu, Zaijie Dong   +7 more
doaj   +1 more source

Ghrelin Modulates Physiologic and Pathologic Retinal Angiogenesis through GHSR-1a [PDF]

Investigative Opthalmology & Visual Science, 2011
Vascular degeneration and the ensuing abnormal vascular proliferation are central to proliferative retinopathies. Given the metabolic discordance associated with these diseases, the authors explored the role of ghrelin and its growth hormone secretagogue receptor 1a (GHSR-1a) in proliferative retinopathy.In a rat model of oxygen-induced retinopathy ...
Zaniolo, Karine, Sapieha, Przemyslaw, Shao, Zhuo, Stahl, Andreas, Zhu, Tang, Tremblay, Sophie, Picard, Emilie, Madaan, Ankush, Blais, Martine, Lachapelle, Pierre, Mancini, Joseph, Hardy, Pierre, Smith, Lois E. H., Ong, Huy, Chemtob, Sylvain   +14 more
openaire   +5 more sources

Uncovering the Genetic Landscape of Spinal Dysraphism: A Retrospective Analysis of 150 Fetal Cases

Prenatal Diagnosis, Volume 46, Issue 5-6, Page 849-861, May 2026.
ABSTRACT Objective Spinal dysraphism (SD) results from incomplete neural tube closure and encompasses a heterogeneous group of congenital anomalies with genetic and environmental etiologies. Although genetic contributions are recognized, causative variants remain insufficiently defined, and the clinical implications of extended genetic testing on ...
I. Bedei, A. Feresin, R. Zemet, D. Berner, D. Polidori, K. Fröbius, A. Skakkebæk, R. Axt‐Fliedner, M. Shoukier, C. Keil   +9 more
wiley   +1 more source

Genetic or pharmacological GHSR blockade has sexually dimorphic effects in rodents on a high-fat diet

Communications Biology
The stomach-derived hormone ghrelin regulates essential physiological functions. The ghrelin receptor (GHSR) has ligand-independent actions; therefore, GHSR gene deletion may be a reasonable approach to investigate the role of this system in feeding ...
András H. Lékó, Adriana Gregory-Flores, Renata C. N. Marchette, Juan L. Gomez, Janaina C. M. Vendruscolo, Vez Repunte-Canonigo, Vicky Choung, Sara L. Deschaine, Kimberly E. Whiting, Shelley N. Jackson, Maria Paula Cornejo, Mario Perello, Zhi-Bing You, Michael Eckhaus, Karuna Rasineni, Kim D. Janda, Barry Zorman, Pavel Sumazin, George F. Koob, Michael Michaelides, Pietro P. Sanna, Leandro F. Vendruscolo, Lorenzo Leggio   +22 more
doaj   +1 more source

Nutrient-sensing growth hormone secretagogue receptor in macrophage programming and meta-inflammation

Molecular Metabolism
Objective: Obesity-associated chronic inflammation, aka meta-inflammation, is a key pathogenic driver for obesity-associated comorbidity. Growth hormone secretagogue receptor (GHSR) is known to mediate the effects of nutrient-sensing hormone ghrelin in ...
Da Mi Kim, Jong Han Lee, Quan Pan, Hye Won Han, Zheng Shen, Sahar Eshghjoo, Chia-Shan Wu, Wanbao Yang, Ji Yeon Noh, David W. Threadgill, Shaodong Guo, Gus Wright, Robert Alaniz, Yuxiang Sun   +13 more
doaj   +1 more source

Advances in the genetics of refractive errors: Contributions from the CREAM consortium

Acta Ophthalmologica, Volume 104, Issue 3, Page e222-e231, May 2026.
Abstract The Consortium for Refractive Error and Myopia (CREAM) was established in 2011, bringing together an international team of researchers studying more than 30 cohorts. Since its establishment, CREAM has played a pivotal role in research investigating the genetics of myopia and other refractive errors, serving as a key driver of progress in the ...
Sze Wai Rosa Li, Xi He, Louise Terry, Virginie J. M. Verhoeven, Samantha Sze‐Yee Lee, Gareth Lingham, Jeremy A. Guggenheim, David A. Mackey, Seang‐Mei Saw, Caroline C. W. Klaver, Chi Pui Pang, CREAM Consortium   +11 more
wiley   +1 more source

Feeding Behaviour in the KPC Model of Pancreatic Cancer‐Associated Cachexia: Alteration of Spontaneous and Evoked Feeding Behaviours

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.
ABSTRACT Background The KPC mouse model of pancreatic cancer is gaining use in research, but detailed understanding of ingestive behaviour changes in this and other cachexia models is limited. Methods Male C57BL/6 J mice (7 weeks) were maintained under standard feed (PicoLab5L0D) and housing conditions (12:12 h; Light:Dark).
Fateema Muzaffar, William F. Colmers, Vickie E. Baracos   +2 more
wiley   +1 more source