Results 71 to 80 of about 5,420 (161)

The Intersection of m6A Methylation and Immune Response in PCOS: A Bioinformatics Perspective

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
N6‐methyladenosine RNA methylation regulators are intricately linked with the development of polycystic ovary syndrome (PCOS) and may influence immune cell infiltration in affected individuals. This study enhances our understanding of the molecular interactions in PCOS and suggests potential biomarkers for diagnosis and targets for therapeutic ...
Wenting Xu, Lingli Shi, Aifang Lu, Lijuan Cui, Haiqing Qian, Jiahui Wang, Mengyu Tang, Lili Zhu, Lihong Wang   +8 more
wiley   +1 more source

Targeted Next‐Generation Sequencing of the Leptin‐Melanocortin Pathway in Severe Obesity

Obesity, Volume 34, Issue 2, Page 499-511, February 2026.
ABSTRACT Objective Pathogenic variants in five established leptin‐melanocortin pathway genes (LEP, LEPR, MC4R, PCSK1, POMC) are associated with severe early‐onset obesity and are targets for emerging treatments. However, these variants are rare in these patients, suggesting the involvement of additional genes interacting with this pathway. Methods Next‐
Nathan Faccioli, Chrisitne Poitou, Mathieu Georget, Françoise Bertin, Ahlam Azar‐Kolakez, Claire Carette, Pauline Faucher, Blandine Gatta‐Cherifi, Julie Gonneau‐Lejeune, Agnès Linglart, Karine Clément, Johanne Le Beyec‐Le Bihan, Béatrice Dubern   +12 more
wiley   +1 more source

Immunohistochemical evidence for an endocrine/paracrine role for ghrelin in the reproductive tissues of sheep

Reproductive Biology and Endocrinology, 2005
Background The gut hormone, ghrelin, is involved in the neuroendocrine and metabolic responses to hunger. In monogastric species, circulating ghrelin levels show clear meal-related and body weight-related changes. The pattern of secretion and its role in
Brown Yvonne A, Harrison Joanne L, Miller David W, Doyle Una, Lindsay Alanna, Adam Clare L, Lea Richard G   +6 more
doaj   +1 more source

An immunohistochemical study of the localization and developmental expression of ghrelin and its functional receptor in the ovine placenta

Reproductive Biology and Endocrinology, 2007
Background Ghrelin is an orexigenic hormone principally produced by the stomach, but also by numerous peripheral tissues including the placenta. Ghrelin acts via growth hormone secretagogue receptors (GHSR-1a) to alter food intake, fat utilization, and ...
Wallace Jacqueline M, Brown Yvonne A, Adam Clare L, Harrison Joanne L, Aitken Raymond P, Lea Richard G, Miller David W   +6 more
doaj   +1 more source

The Developmental Changes of mRNAs Expression Levels of GHSR Gene in Sheep

AASRI Procedia, 2014
Different age group of Male Kazak sheep and Xinjiang fine wool sheep were used in the current study to investigate the developmental changes of GHSR mRNA expression. After measurement of body weight, hypothalamus and pituitary were sampled to extract total RNA for determining the abundance of GHSR mRNA by RT-PCR and real-time PCR. The results indicated
Huang, Zhiguo, Wei, Chunhui, Luo, Huibo, Bian, Minghong, Deng, Jie, Liu, Yanmei   +5 more
openaire   +1 more source

GHSR gene knockout alleviates the liver pathological response in Echinococcus granulosus infection by reducing parasite survival

Veterinary Research
Cystic echinococcosis (CE) is a parasitic disease caused by the larval stage of Echinococcus granulosus, and the immunosuppressive microenvironment exacerbates disease progression.
Jiang Zhu, Tanfang Zhou, Guangfeng Chen, Huijing Gao, Xia Chen, Ayinula Tuohetali, Ya Song, Dongming Pang, Kalibixiati Aimulajiang   +8 more
doaj   +1 more source

Bladder Cancer detection by urinary methylation markers GHSR/MAL: a validation study

World Journal of Urology
Abstract Purpose Although cystoscopy is a reliable tool for detecting bladder cancer, it poses a high burden on patients and entails high costs. This highlights the need for non-invasive and cost-effective alternatives. This study aimed to validate a previously developed urinary methylation marker panel containing GHSR ...
Beijert, I. J., van den Burgt, Y., Hentschel, A. E., Bosschieter, J., Kauer, P. C., Lissenberg-Witte, B. I., van Moorselaar, R. J. A., Nieuwenhuijzen, J. A., Steenbergen, R. D. M.   +8 more
openaire   +3 more sources

A large and unusual lung abscess with positive culture to Slackia exigua

International Journal of Infectious Diseases, 2015
C. Roingeard, J. Jaubert, L. Guilleminault   +2 more
doaj   +1 more source

The Pathologic Roles and Therapeutic Implications of Ghrelin/GHSR System in Mental Disorders

Depression and Anxiety
Ghrelin is a hormone consisting of 28 amino acids. Growth hormone secretagogue receptor (GHSR) is a receptor for ghrelin, which is expressed in the brain, pituitary gland, and adrenal glands, especially in the hypothalamus. The binding of ghrelin to the receptor 1a subtype mediates most of the biological effects of ghrelin.
Qianshuo Mao, Jinjia Wang, Zihan Yang, Ruidong Ding, Shuangyu Lv, Xinying Ji   +5 more
openaire   +2 more sources

Exploring the Relationship Between Growth Hormone Secretagogue Receptor (GHSR) Gene and Body Proportions in Bangkok Chickens: Insights from DNA Sequencing and Hin6I Enzyme-Restricted PCR-RFLP Analysis

Jurnal Medik Veteriner
The purpose of this study was to determine the diversity of the growth hormone secretagogue receptor (GHSR) gene and also to analyze the association of the GHSR gene with the body proportions of Bangkok chickens.
Gayuh Syaikhullah, Rosa Tri Hertamawati, Muhammad Adhyatma   +2 more
doaj   +1 more source