Results 91 to 100 of about 6,435 (196)

Ghrelin/GHSR System in Depressive Disorder: Pathologic Roles and Therapeutic Implications

Current Issues in Molecular Biology
Depression is the most common chronic mental illness and is characterized by low mood, insomnia, and affective disorders. However, its pathologic mechanisms remain unclear. Numerous studies have suggested that the ghrelin/GHSR system may be involved in the pathophysiologic process of depression.
Xingli Pan, Yuxin Gao, Kaifu Guan, Jing Chen, Bingyuan Ji   +4 more
openaire   +3 more sources

Therapeutic potential of ghrelin/GOAT/GHSR system in gastrointestinal disorders

Frontiers in Nutrition
Ghrelin, a peptide primarily secreted in the stomach, acts via the growth hormone secretagogue receptor (GHSR). It regulates several physiological processes, such as feeding behavior, energy homeostasis, glucose and lipid metabolism, cardiovascular function, bone formation, stress response, and learning.
Yunxiao Ma, Qihui Yan, Ping Wang, Weiying Guo, Lu Yu   +4 more
openaire   +3 more sources

GHSR in a Subset of GABA Neurons Controls Food Deprivation-Induced Hyperphagia in Male Mice

International audienceThe growth hormone secretagogue receptor (GHSR), primarily known as the receptor for the hunger hormone ghrelin, potently controls food intake, yet the specific Ghsr-expressing cells mediating the orexigenic effects of this receptor
Andreoli, María Florencia, Quelas, Juan Ignacio, Pla, Ramon, Cabral, Agustina,, Zubimendi Sampieri, Juan Pablo, García Romero, Guadalupe, Barrile, Franco,, Quelas, Juan Ignacio,, Cantel, Sonia, Zubimendi Sampieri, Juan Pablo,, Fernandez, Gimena, Cornejo, María Paula,, García Romero, Guadalupe,, Andreoli, María Florencia,, Ferran, José Luis, Cornejo, María Paula, Perelló, Mario, Fernandez, Gimena,, Barrile, Franco, Fehrentz, Jean-Alain,, Heredia, Florencia,, Fehrentz, Jean-Alain, Alonso, Antonia, Cantel, Sonia,, Cabral, Agustina, de Francesco, Pablo Nicolas, De Francesco, Pablo Nicolas,, Ferran, José Luis,, Alonso, Antonia,, Heredia, Florencia, Pla, Ramon,, Perelló, Mario,   +31 more
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The Developmental Changes of mRNAs Expression Levels of GHSR Gene in Sheep

AASRI Procedia, 2014
Different age group of Male Kazak sheep and Xinjiang fine wool sheep were used in the current study to investigate the developmental changes of GHSR mRNA expression. After measurement of body weight, hypothalamus and pituitary were sampled to extract total RNA for determining the abundance of GHSR mRNA by RT-PCR and real-time PCR. The results indicated
Huang, Zhiguo, Wei, Chunhui, Luo, Huibo, Bian, Minghong, Deng, Jie, Liu, Yanmei   +5 more
openaire   +1 more source

Severe congenital hyperinsulinism with progressive neurological deterioration due to novel HADH-GHSR digenic mutations: the first case report

Congenital hyperinsulinism (CHI) represents a complex group of genetic disorders causing inappropriate insulin secretion. We report the first case of severe CHI caused by a novel combination of HADH and GHSR mutations, leading to an unusually severe ...
Rachid Abilkassem, Abdelilah Radi, Azzeddine Laaraje, Aomar Agadr   +3 more
core   +1 more source

An immunohistochemical study of the localization and developmental expression of ghrelin and its functional receptor in the ovine placenta

Reproductive Biology and Endocrinology, 2007
Background Ghrelin is an orexigenic hormone principally produced by the stomach, but also by numerous peripheral tissues including the placenta. Ghrelin acts via growth hormone secretagogue receptors (GHSR-1a) to alter food intake, fat utilization, and ...
Wallace Jacqueline M, Brown Yvonne A, Adam Clare L, Harrison Joanne L, Aitken Raymond P, Lea Richard G, Miller David W   +6 more
doaj   +1 more source

GHSR gene knockout alleviates the liver pathological response in Echinococcus granulosus infection by reducing parasite survival

Veterinary Research
Cystic echinococcosis (CE) is a parasitic disease caused by the larval stage of Echinococcus granulosus, and the immunosuppressive microenvironment exacerbates disease progression.
Jiang Zhu, Tanfang Zhou, Guangfeng Chen, Huijing Gao, Xia Chen, Ayinula Tuohetali, Ya Song, Dongming Pang, Kalibixiati Aimulajiang   +8 more
doaj   +1 more source

Midbrain ghrelin receptor signalling regulates binge drinking in a sex specific manner

Nature Communications
Risky drinking rates are rising, particularly in women, yet sex as a biological variable has only recently gained traction. The centrally projecting Edinger-Westphal (EWcp) nucleus has emerged as a key regulator of alcohol consumption. Here we found that
Amy J. Pearl, Xavier J. Maddern, Paulo Pinares-Garcia, Lauren T. Ursich, Roberta G. Anversa, Arnav Shesham, Robyn M. Brown, Felicia M. Reed, William J. Giardino, Andrew J. Lawrence, Leigh C. Walker   +10 more
doaj   +1 more source

A genetic study of the ghrelin and growth hormone secretagogue receptor (GHSR) genes and stature.

, 2009
Growth and nutrition are interrelated and influenced by multiple genetic and environmental factors. We studied whether common variants in ghrelin and ghrelin receptor (GHSR) genes could play a role in stature variation in the general population and in ...
Grossman, AB, Benzinou, M, Meyre, D, A. B. Grossman, M. Korbonits, Lecoeur, C, D. Meyre, B. Heude, C. Lecoeur, V. Vatin, Gueorguiev, M, Mein, CA, M. Benzinou, Korbonits, M, M. Gueorguiev, Heude, B, J. Weill, Weill, J, P. Froguel, Vatin, V, Froguel, P, C. A. Mein   +21 more
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The Pathologic Roles and Therapeutic Implications of Ghrelin/GHSR System in Mental Disorders

Depression and Anxiety
Ghrelin is a hormone consisting of 28 amino acids. Growth hormone secretagogue receptor (GHSR) is a receptor for ghrelin, which is expressed in the brain, pituitary gland, and adrenal glands, especially in the hypothalamus. The binding of ghrelin to the receptor 1a subtype mediates most of the biological effects of ghrelin.
Qianshuo Mao, Jinjia Wang, Zihan Yang, Ruidong Ding, Shuangyu Lv, Xinying Ji   +5 more
openaire   +2 more sources