Results 31 to 40 of about 24,193 (193)

Quantitative Systems Toxicology Model Predicts Obeticholic Acid‐Associated Liver Injury in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Clinical Pharmacology &Therapeutics, EarlyView.
Obeticholic acid (OCA), a synthetic analog of chenodeoxycholic acid, was approved in 2016 for the treatment of primary biliary cholangitis. Early clinical trials revealed elevated liver biomarkers in healthy subjects receiving supratherapeutic OCA doses (100–250 mg).
Abigail K. Mayo, James J. Beaudoin, Jeffrey L. Woodhead, Paul B. Watkins, Kim L. R. Brouwer   +4 more
wiley   +1 more source

Investigating the shared genetic information between serum concentration levels of liver enzymes and cholelithiasis

BMC Gastroenterology
Background Liver injury is associated with cholelithiasis, with changes in liver enzyme levels potentially influencing cholelithiasis risk. This study investigates the shared genetic basis between serum levels of four liver enzymes and cholelithiasis ...
Wenhao Tian, Zixin Wu, Wen Yang, Hongyang Wang, Qiyu Feng   +4 more
doaj   +1 more source

Complicated Acute Appendicitis Conservatively Treated in Two Patients With Crohn's Disease: The Role of Intestinal Ultrasound and Contrast‐Enhanced Ultrasound

Journal of Clinical Ultrasound, EarlyView.
Intestinal ultrasound and contrast‐enhanced ultrasound were used to diagnose, monitor, and guide conservative treatment of complicated acute appendicitis in two patients with Crohn's disease. Serial imaging enabled early identification of treatment response, allowing long‐term surgery‐free outcomes.
Cataletti Giovanni, Gridavilla Daniele, Nylund Kim, Colombo Francesco, Danelli Piergiorgio, Maconi Giovanni   +5 more
wiley   +1 more source

Frequency of Cholelithiasis in Patients with Chronic Liver Disease: A Hospital-Based Study [PDF]

Afro-Egyptian Journal of Infectious and Endemic Diseases, 2016
Background and study aim: Liver Cirrhosis is a strong and a common known risk factor for Cholelithiasis. Cholelithiasis is a multifactorial disease, based on a complex interaction of environmental and genetic factors.
Mona Abdelmaksoud, Hoda El-Hady, Hussein Ahmed, Bihery Ahmed, Hala Hussein, Mostafa El-Shamy   +5 more
doaj   +1 more source

Adherence to Diagnostic Imaging Pathways for Patients Presenting to Emergency Departments With Undifferentiated Acute Abdominal Pain: Impact on Radiation Exposure and Multiple Imaging Testing

Journal of Medical Radiation Sciences, EarlyView.
There are many recommendations and guidelines when it comes to medical imaging, but just how effective and useful are they? This article examines this topic with regards to the RANZCR Imaging Pathways and acute abdominal pain. ABSTRACT Introduction The Diagnostic Imaging Pathways (DIP) are a tool that has been developed to assist physicians with ...
Brian Evans, Nicola Giannotti, Ernest Ekpo   +2 more
wiley   +1 more source

Triglyceride‐Related Indices and Risk of Acute Pancreatitis: A Prospective Study in UK Biobank

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Triglyceride‐related indices, including triglyceride‐glucose (TyG), TyG related to body mass index (TyG‐BMI), TyG related to waist circumference (TyG‐WC), TyG related to waist‐to‐height ratio (TyG‐WHtR), atherogenic index of plasma (AIP), cardiometabolic index (CMI), visceral adiposity index (VAI), and lipid accumulation product (LAP), are ...
Jing‐Bo Li, Yu‐Jiao Zhu, Yang‐Jie Liao, Jia‐Yi Wang   +3 more
wiley   +1 more source

Analysis of Intraoperative Complications and Outcomes Associated With Obesity During Elective Laparoscopic Cholecystectomy

World Journal of Surgery, EarlyView.
As obesity becomes more common, understanding its risks in routine operations is increasingly important. This study assessed the impact of obesity on intraoperative complications during elective laparoscopic cholecystectomy. Obesity significantly increases the risks of intraoperative complications in patients undergoing elective cholecystectomy, as ...
Thomas Coates, Marek Bak, Ashray Rajagopalan, Filip Pesevski, Anjana Ravi, Daniel Croagh, Geraldine Ooi   +6 more
wiley   +1 more source

Association Between Regular Use of Gastric Acid Suppressants and Subsequent Risk of Cholelithiasis: A Prospective Cohort Study of 0.47 Million Participants

Frontiers in Pharmacology, 2022
Background: Gastric acid suppressants have a major impact on gut microbiome which in turn, may increase the risk of cholelithiasis, but epidemiological evidence remains unclear.
Man Yang, Man Yang, Man Yang, Bin Xia, Bin Xia, Yawen Lu, Yawen Lu, Qiangsheng He, Qiangsheng He, Yanyan Lin, Ping Yue, Bing Bai, Chunlu Dong, Wenbo Meng, Wenbo Meng, Jian Qi, Jinqiu Yuan, Jinqiu Yuan, Jinqiu Yuan   +18 more
doaj   +1 more source

Imaging of Abdominal Complications in Children With Acute Lymphoblastic Leukaemia

Journal of Medical Imaging and Radiation Oncology, EarlyView.
ABSTRACT Acute lymphoblastic leukaemia (ALL) is the most common paediatric malignancy and remains one of the most common causes of cancer‐related death in children and adolescents. Five‐year overall survival rates now exceed 90% with current multidrug chemotherapeutic regimens. This improvement, coupled with the toxicity of chemotherapy, has led to the
Luke R. Holmes, Rishi S. Kotecha, Derek J. Roebuck   +2 more
wiley   +1 more source

DISCHOLERETIC AND DYSCHOLEREKINETIC FACTORS AND MECHANISMS OF DEVELOPMENT OF CHOLESTEROL CHOLELITHIASIS

Медицина в Кузбассе, 2022
There are many theories of the genesis of cholelithiasis in the literature, but none of the theories is perfect. Currently, there are no works on the development of experimental prevention of cholesterol cholelithiasis, based on the etiology of ...
Леонид Николаевич Иванов, Марина Леонидовна Колотилова, Наталья Викторовна Алексеева   +2 more
doaj