Results 51 to 60 of about 120,843 (272)

Synthesis, In Silico, and Biological Evaluation of Non‐Hydroxamate Benzoic Acid–Based Derivatives as Potential Histone Deacetylase Inhibitors (HDACi)

Chemistry &Biodiversity, EarlyView.
Compound A3bn exhibited strong binding affinities for HDAC2, HDAC6, and HDAC8. A3bn’s anticancer IC50 values were similar to those of SAHA. Cell death resulted from the extrinsic apoptotic pathway. Compound A3bn, a hydrophilic linker, which promotes zinc coordination, may be the cause of its increased activity across HDAC isoforms. ABSTRACT Unregulated
Nedaa A. Abd Al Rahim, Ammar A. Razzak Mahmood, Lubna H. Tahtamouni, Randa M. Bawadi, Ayah Y. Almasri, Marya A. Hamad, Nour A. Hussein, Salem R. Yasin, Abdulrahman M. Saleh   +8 more
wiley   +1 more source

SARS-CoV-2 nucleocapsid protein promotes self-deacetylation by inducing HDAC6 to facilitate viral replication

Virology Journal
Background The global outbreak of COVID-19 caused by the SARS-CoV-2 has led to millions of deaths. This unanticipated emergency has prompted virologists across the globe to delve deeper into the intricate dynamicity of the host-virus interface with an ...
Arpita Mukherjee, Mahadeb Lo, Pritam Chandra, Ratul Datta Chaudhuri, Papiya De, Shanta Dutta, Mamta Chawla-Sarkar   +6 more
doaj   +1 more source

The Aging Gut–Brain Axis: Effects of Dietary Polyphenols and Metal Exposure

Chronic Diseases and Translational Medicine, EarlyView.
The influence of gut microbiota on brain health ABSTRACT Diet provides essential metals, which are required for the growth, development, and well‐functioning of the body. Nonetheless, some natural and human activities add toxic heavy metals to the diet, consequently introducing them to our bodies, resulting in several disorders and death. The intestine,
Luqi Cao, Saurabh Kumar Jha, Neha Gupta, Xiang Chen, Renuka Soni, Luoxi Yuan, Rashi Srivastava, Zhe‐Sheng Chen   +7 more
wiley   +1 more source

Cu or Fe‐Exchanged Natural Clinoptilolite as Sustainable Light‐Assisted Catalyst for Water Disinfection at Near Neutral pH

ChemPlusChem, EarlyView.
Fe and Cu exchanged natural clinoptilolites are evaluated as heterogeneous photo‐Fenton catalysts for water disinfection under visible light, using E. coli as a model pathogen. Bacterial detection limit is reached in 2 h, with no regrowth observed.
Paula Prieto‐Laria, Pilar Fernández‐Ibáñez, A. Rabdel Ruiz‐Salvador, Inés Canosa, Amando Flores, Carlos Salameh, José Enrique Domínguez‐Santos, Nuria Ofelia Núñez, Menta Ballesteros, Tania Farías   +9 more
wiley   +1 more source

Correction: Saha et al. Unveiling the Antiviral Potential of Minocycline: Modulation of Nuclear Export of Viral Ribonuclear Proteins during Influenza Virus Infection. Viruses 2024, 16, 1317

Viruses
In the original publication [...]
Priyanka Saha, Ritubrita Saha, Ratul Datta Chaudhuri, Rakesh Sarkar, Mehuli Sarkar, Hemanta Koley, Mamta Chawla-Sarkar   +6 more
doaj   +1 more source

The State of Public Health in Somalia: Top 5 Challenges and Strategies for Improvement. [PDF]

Public Health Chall
Somalia's public health system is severely strained by five interconnected challenges: inadequate WASH infrastructure, widespread malnutrition and food insecurity, high burden of infectious diseases, critical gaps in maternal and child health, and the rising prevalence of noncommunicable diseases (NCDs).
Abdi YH, Abdi MS, Bashir SG, Ahmed NI, Abdullahi YB.   +4 more
europepmc   +2 more sources

Foodborne Hazards and Novel Technologies in Ready‐to‐Eat Crustaceans

Food Frontiers, EarlyView.
Biological hazards, including Listeria monocytogenes, norovirus, Salmonella, and Vibrio spp., and chemical hazards, including heavy metals, biotoxins, pesticides, pharmaceuticals, and personal care products, are of great concern regarding crustaceans and their consumption.
Dongli Dong, Selene Pedrós‐Garrido, Daniel Hurley, James Lyng   +3 more
wiley   +1 more source

Exploring the Role of Acrylamide in Food Allergy via Dendritic Cell‐Dependent Th2 Immune Responses

Food Frontiers, EarlyView.
Acrylamide may disrupt immune tolerance as a foodborne immunotoxicant, priming allergic inflammatory susceptibility through DC‐dependent Th2/Th17 polarization, TLR4/NF‐κB signaling amplification, and IL‐10 production suppression. ABSTRACT Acrylamide (AA), a prevalent food processing contaminant with recognized multi‐organ toxicity, has an unexplored ...
Xue Feng, Jiamin Chen, Zhencong Yang, Philippe Madjirebaye, Zhoujin Xu, Li Yan, Yuting Fan, Xiaoliang Shu, Xuli Wu   +8 more
wiley   +1 more source

Transforming district health systems into learning health systems: An improved strategy from the District.Team experience in Benin and Guinea

Learning Health Systems, EarlyView.
Abstract District Health Systems (DHS) are essential for delivering healthcare services, particularly in low‐ and middle‐income countries. However, they often struggle with inefficiencies, inadequate data utilization, and limited learning capacity. Transforming DHS into Learning Health Systems (LHS) offers a strategic pathway to strengthening health ...
Tamba Mina Millimouno, Kéfilath Olatoyossi Akankè Bello, Jean‐Paul Dossou, Alexandre Delamou, Bruno Meessen   +4 more
wiley   +1 more source

Unveiling the Antiviral Potential of Minocycline: Modulation of Nuclear Export of Viral Ribonuclear Proteins during Influenza Virus Infection

Viruses
Influenza A virus (IAV) poses a global threat worldwide causing pandemics, epidemics, and seasonal outbreaks. Annual modification of vaccines is costly due to continual shifts in circulating genotypes, leading to inadequate coverage in low- and middle ...
Priyanka Saha, Ritubrita Saha, Ratul Datta Chaudhuri, Rakesh Sarkar, Mehuli Sarkar, Hemanta Koley, Mamta Chawla-Sarkar   +6 more
doaj   +1 more source