Results 41 to 50 of about 123,784 (235)

When, How, and Where can Oral Cholera Vaccines be Used to Interrupt Cholera Outbreaks? [PDF]

, 2014
Cholera continues to be a major global health problem, at times causing major and prolonged outbreaks in both endemic and nonendemic settings in developing countries.
John Clemens, Holmgren, Jan,, Jan Holmgren, Clemens, John   +3 more
core   +1 more source

Membrane Fusion‐Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng, Tristan Juin Han Chang, Xinchao Li, Zhongqi Zhou, Chung Tin, Kenward Vong, Pierre Karam, Pik Kwan Lo   +7 more
wiley   +1 more source

Epidemiology of typhoid and paratyphoid fever in India

Journal of Infection in Developing Countries, 2008
Enteric fever (typhoid and paratyphoid fever) is a major human bacterial infection. Although the disease is not common in industrialised countries, it remains an important and persistent health problem in developing nations.
Suman Kanungo, Shanta Dutta, Dipika Sur
doaj   +1 more source

ANXA2+ Small Extracellular Vesicles Drive Chemoresistance in Anaplastic Thyroid Cancer by Promoting XRCC5 Lactylation and Enhancing Non‐Homologous End‐Joining Repair

Advanced Science, EarlyView.
ANXA2+ sEVs promote cisplatin resistance in ATC by stabilizing the SRC/LDHA interaction, increasing LDHA phosphorylation and activity, and lactate production. Elevated lactate levels promote KAT5‐mediated lactylation of XRCC5 at lysine 265, enhancing its binding to XRCC6.
Shanshan Su, YiShan Xiong, Yuxuan Liang, Xiang Min, Daofeng Dai   +4 more
wiley   +1 more source

Isolation, characterization, and application of a novel polyvalent lytic phage STWB21 against typhoidal and nontyphoidal Salmonella spp.

Frontiers in Microbiology, 2022
Salmonella is one of the common causal agents of bacterial gastroenteritis-related morbidity and mortality among children below 5 years and the elderly populations.
Payel Mondal, Bani Mallick, Moumita Dutta, Shanta Dutta   +3 more
doaj   +1 more source

Histidine Supplementation Stabilizes Hearing and Vision and Improves Growth in HARS1‐Related Autosomal Recessive Disorder Associated With Usher‐Like Symptoms

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Autosomal recessive HARS1‐related disorder (originally described as Usher syndrome type 3B) caused by a homozygous Y454S variant in the histidyl‐tRNA synthetase gene (HARS1) is characterized by progressive sensorineural hearing and vision loss and respiratory deterioration with risk for sudden death following febrile illnesses.
Victoria Mok Siu, Rosan Kenana, Rana Chakrabarti, Sarah D. P. Wilhelm, Joseph Andrews, Susan J. Leat, Christina Parker, Michael Miller, Leslie A. Nangle, Wendy McCaul, Ashfia Chowdhury, Natalie Hutchings, Ryan A. Adams, Lauren Guy, Mandy Rhody, Verena Juncal, Marisa I. Mendes, Desiree E. C. Smith, Gajja S. Salomons, Angelica A. Moresco, Daphne L. McCulloch, D. Holmes Morton, Ilka U. Heinemann, C. Anthony Rupar   +23 more
wiley   +1 more source

Curing Cholera: Pathogens, Places and Poverty in South Asia [PDF]

, 2010
In this paper I will seek to provide a new understanding of endemicity of disease in India. Through a study of cholera research in the twentieth century I will argue that disease and its endemicity has to be understood in biological factors as well as ...
Chakrabarti, Pratik
core  

Contribution of veterinary sector to antimicrobial resistance in One Health compendium: an insight from available Indian evidence

Frontiers in Veterinary Science
The application of antibiotics in the poultry and veterinary sectors is very common practice in India. Owing to the seriousness of antimicrobial resistance (AMR), the present study has illustrated the overall scenario of AMR in the poultry and veterinary
Debjit Chakraborty, Falguni Debnath, Sandip Giri, Shatabdi Saha, Soume Pyne, Raja Chakraverty, Agniva Majumdar, Alok Kumar Deb, Rajesh Bhatia, Shanta Dutta   +9 more
doaj   +1 more source

Haitian Variant Vibrio cholerae O1 Strains Manifest Higher Virulence in Animal Models

Frontiers in Microbiology, 2019
Vibrio cholerae causes fatal diarrheal disease cholera in humans due to consumption of contaminated water and food. To instigate the disease, the bacterium must evade the host intestinal innate immune system; penetrate the mucus layer of the small ...
Priyanka Ghosh, Ritam Sinha, Prosenjit Samanta, Dhira Rani Saha, Hemanta Koley, Shanta Dutta, Keinosuke Okamoto, Amit Ghosh, T. Ramamurthy, Asish K. Mukhopadhyay   +9 more
doaj   +1 more source

An Experimental Adult Zebrafish Model for Shigella Pathogenesis, Transmission, and Vaccine Efficacy Studies

Microbiology Spectrum, 2022
Shigellosis has been a menace to society for ages. The absence of an effective vaccine against Shigella, improper sanitation, and unhygienic use of food and water allow the disease to flourish.
Debaki R. Howlader, Ushasi Bhaumik, Prolay Halder, Aishwarya Satpathy, Sounak Sarkar, Mrinalini Ghoshal, Suhrid Maiti, Jeffrey H. Withey, Jiro Mitobe, Shanta Dutta, Hemanta Koley   +10 more
doaj   +1 more source