An Update on Cholera Immunity and Current and Future Cholera Vaccines [PDF]
Tropical Medicine and Infectious Disease, 2021 Individual resistance to cholera infection and disease depends on both innate host factors and adaptive immunity acquired by a previous infection or vaccination.
Jan Holmgren
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Allocation of Oral Cholera Vaccines in Africa [PDF]
VaccinesObjectives: In this study, we examine the allocation of oral cholera vaccines (OCVs) across 25 African countries between 2013 and 2019. Methods: We constructed a dataset combining cholera outbreaks and requests, decisions, and deliveries of OCVs from the
Elisa M. Maffioli, Yutong Lu
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Cholera, the Current Status of Cholera Vaccines and Recommendations for Travellers [PDF]
Vaccines, 2020 Cholera is endemic in approximately 50 countries, primarily in Africa and South and Southeast Asia, and in these areas, it remains a disease associated with poverty.
Giovanni Gabutti +8 more
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Controlling endemic cholera with oral vaccines. [PDF]
PLoS Medicine, 2007 Although advances in rehydration therapy have made cholera a treatable disease with low case-fatality in settings with appropriate medical care, cholera continues to impose considerable mortality in the world's most impoverished populations ...
Ira M Longini +5 more
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Oral cholera vaccines and their impact on the global burden of disease [PDF]
Human Vaccines & Immunotherapeutics, 2019 With one-third of nations at risk of cholera, we can expect to experience massive, rapidly disseminated, and prolonged cholera outbreaks such as those recently experienced in Yemen and Haiti.
Thomas F. Wierzba
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Prospective observational studies to provide confidence in the protection conferred by newer generation, inactivated oral cholera vaccines: a proposal [PDF]
EClinicalMedicineSummary: Inactivated oral cholera vaccines (OCVs) are a cornerstone of international efforts to control cholera, and are currently deployed from a global stockpile for the control of epidemics and endemic hotspots, as well as for humanitarian emergencies.
John Clemens +2 more
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Achievements and challenges for the use of killed oral cholera vaccines in the global stockpile era [PDF]
Human Vaccines & Immunotherapeutics, 2017 Cholera remains an important but neglected public health threat, affecting the health of the poorest populations and imposing substantial costs on public health systems.
Sachin N. Desai +6 more
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The case for evaluation of double mutant heat-labile toxin as an adjuvant to improve oral cholera vaccine immunogenicity [PDF]
Frontiers in ImmunologyCholera has re-emerged as a major global public health threat. Orally administered attenuated or inactivated vaccines offer protection against enteric pathogens such as Vibrio cholerae, and several World Health Organization-prequalified oral cholera ...
A. Louis Bourgeois +8 more
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Vibrio cholerae O1 classical and El Tor toxin-coregulated pilus subunit A (TcpA) epitopes that induce biotype-specific and cross-protective antibodies against bacterial adherence [PDF]
Applied and Environmental MicrobiologyThe persistent and deadly cholera remains a significant burden on global health. Current countermeasures are inadequate against cholera. Toxin-coregulated pilin (TCP) has long been a target for understanding the biogenesis of Vibrio cholerae infection ...
Sai Simha Reddy Vakamalla +2 more
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Systemic, Mucosal, and Memory Immune Responses following Cholera
Tropical Medicine and Infectious Disease, 2021 Vibrio cholerae O1, the major causative agent of cholera, remains a significant public health threat. Although there are available vaccines for cholera, the protection provided by killed whole-cell cholera vaccines in young children is poor.
Edward T. Ryan +11 more
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