Vaccines in the time of cholera [PDF]
Proceedings of the National Academy of Sciences, 2011 Cholera, an acute watery diarrheal disease caused by Vibrio cholerae 01 and, less commonly, by V. cholerae 0139, is a major global public health problem in developing countries, causing an estimated 100,000 deaths per year and resulting in major microeconomic and macroeconomic losses.
openaire +2 more sources
Production of putative enhanced oral cholera vaccine strains that express toxin-coregulated pilus. [PDF]
PLoS ONE, 2017 The use of whole cell killed (WCK) oral cholera vaccines is an important strategy for cholera prevention in endemic areas. To overcome current vaccine limitations, we engineered strains of V.
Caitlyn A Hauke, Ronald K Taylor
doaj +1 more source
Intradermal cholera vaccination [PDF]
Journal of Hygiene, 1964 The protection afforded by cholera vaccine administered by the intradermal route, and demonstrated by active and passive mouse protection tests, active guinea-pig protection tests, and agglutination titres, is excellent and equal to that given by subcutaneous inoculation.It is suggested that cholera vaccine administered by the intradermal route would ...
openaire +2 more sources
The influence of immunomodulators on the formation of vaccine-induced cholera immunity
Журнал микробиологии, эпидемиологии и иммунобиологии, 2022 Introduction. Due to the remaining tense situation on cholera in the world, research continues on the creation of new preventive drugs, as well as ways to increase the immunogenicity of existing anti-cholera vaccines.
A. V. Filippenko +3 more
doaj +1 more source
The value of and challenges for cholera vaccines in Africa. [PDF]
, 2013 The 21st century saw a shift in the cholera burden from Asia to Africa. The risk factors for cholera outbreaks in Africa are incompletely understood, and the traditional emphasis on providing safe drinking water and improving sanitation and hygiene has ...
Luquero, F J +5 more
core +1 more source
Urban Cholera transmission hotspots and their implications for Reactive Vaccination: evidence from Bissau city, Guinea Bissau [PDF]
, 2012 Use of cholera vaccines in response to epidemics (reactive vaccination) may provide an effective supplement to traditional control measures. In Haiti, reactive vaccination was considered but, until recently, rejected in part due to limited global supply ...
Lessler, Justin +45 more
core +1 more source
A dysbiotic gut microbiome suppresses antibody mediated-protection against Vibrio cholerae
iScience, 2021 Summary: Cholera is a severe diarrheal disease that places a significant burden on global health. Cholera’s high morbidity demands effective prophylactic strategies, but oral cholera vaccines exhibit variable efficacy in human populations.
John C. Macbeth +3 more
doaj +1 more source
Methods to assess the impact of mass oral cholera vaccination campaigns under real field conditions. [PDF]
PLoS ONE, 2014 There is increasing interest to use oral cholera vaccination as an additional strategy to water and sanitation interventions against endemic and epidemic cholera.
Jacqueline Deen +2 more
doaj +1 more source
Dual Burden of Conflicts and Healthcare Collapse in the Democratic Republic of Congo: A Call for Action. [PDF]
Public Health ChallThe dual burden of conflict and healthcare attacks in the DRC has led to system collapse, resulting in the destruction of facilities, massive displacement, and the resurgence of deadly outbreaks. Urgent global action and coordinated, sustained investments are imperative to protect health services and prevent further catastrophe.
Cyubahiro E, Benimana D.
europepmc +2 more sources
Gas phase characterization of the noncovalent quaternary structure of Cholera toxin and the Cholera toxin B subunit pentamer [PDF]
, 2006 Cholera toxin (CTx) is an AB5 cytotonic protein that has medical relevance in cholera and as a novel mucosal adjuvant. Here, we report an analysis of the noncovalent homopentameric complex of CTx B chain (CTx B5) using electrospray ionization triple ...
Jennings, Keith R. +8 more
core +1 more source