Results 131 to 140 of about 41,359 (179)

Vibrio cholerae: Cholera Toxin

International Journal of Biochemistry and Cell Biology, 2007
The bacterial protein toxin of Vibrio cholerae, cholera toxin, is a major agent involved in severe diarrhoeal disease. Cholera toxin is a member of the AB toxin family and is composed of a catalytically active heterodimeric A-subunit linked with a homopentameric B-subunit.
vanden Broeck, Davy, Horvath, Caroline A.J., de Wolf, Marc J.S.   +2 more
exaly   +4 more sources

Cholera toxin (Vibrio cholerae)

1997
Abstract CT is composed of two subunits, A and B, of 27 and 57.5 kDa respectively, held together by noncovalent interactions. The B subunit which contains the receptor binding site, is formed by five identical monomers, each of 11.5 kDa which assemble into a ring like oligomeric structure having a central hole.
M Pizza, M R Fontana, R Rappuoli
openaire   +1 more source

Preclinical pharmacology of cholera toxin

Cancer Chemotherapy and Pharmacology, 1995
Cholera toxin was selected for pharmacologic evaluation by the National Cancer Institute on the basis of antiproliferative activity against small-cell and non-small-cell lung-cancer cell lines. A feature common to the sensitive cell lines was abundant expression of GM1 ganglioside, the cellular receptor for cholera toxin.
J M, Reid, J W, Benson, J, Viallet, M M, Ames   +3 more
openaire   +2 more sources

Crystalline Cholera Toxin and Toxoid

Science, 1972
The exo-enterotoxin of Vibrio cholerae has been obtained in crystalline form. A solution of the crystalline protein was equal in potency to the parent pure toxin in both choleragenicity and skin reactivity. Crystals of the natural toxoid, choleragenoid, resemble those of the toxin in appearance.
R A, Finkelstein, J J, LoSpalluto
openaire   +2 more sources

Characterization and Purification of Cholera Toxin

Journal of Infectious Diseases, 1970
Studies on both the characterization and purification of the toxic component in crude culture filtrates of Vibrio cholerae were pursued simultaneously since it was felt that knowledge of properties of the toxin would aid in the procedure for purification.
R J, Heckly, H, Wolochow
openaire   +2 more sources

Deactivation of Cholera Toxin by Ganglioside

Journal of Infectious Diseases, 1971
cholerae leads to the profuse secretory activity seen in choleraic diarrhea. Lipidcontaining extracts of various tissues were found to inhibit the activity of cholera toxin; the highest amounts of the inhibitory factor were found in brain. The inhibitor has properties similar to those of gangliosides.
W E, Van Heyningen, C C, Carpenter, N F, Pierce, W B, Greenough   +3 more
openaire   +2 more sources

Heterogeneity of purified cholera toxin

Biochimica et Biophysica Acta (BBA) - Protein Structure, 1977
The heterogeneity of Vibrio cholerae toxin, obtained from culture filtrates in homogeneous form by gel filtration and preparative disc gel electrophoresis has been studied. By means of disc electrophoresis on polyacrylamide gel cholera toxin was separated into three forms designated I (5%), II (15%) and III (80%). The toxic activity, amino acid content
L G, Roda, M, Tomasi, A, Battistini, I, Luzzi, P, Mastrantonio, A, Zampieri, G, D'Agnolo   +6 more
openaire   +2 more sources

Localization of Cholera Toxin In Vivo

Journal of Infectious Diseases, 1972
Immunohistochemical techniques, done with fluorescein- and horseradish peroxidase-labeled antibodies specifically purified by immunoadsorption, were used to show cholera-toxin antigen in intestinal tissues from adult mice injected intraluminally with highly purified cholera toxin.
J W, Peterson, J J, LoSpalluto, R A, Finkelstein   +2 more
openaire   +2 more sources

On the similarity of tetanus and cholera toxins

Naunyn-Schmiedeberg's Archives of Pharmacology, 1973
There are several similarities between tetanus and cholera toxins, including their ability to react with ganglioside. However, tetanus toxin reacts mostly with certain gangliosides containing sialidase-sensitive bonds, whereas cholera toxin reacts only with one particular ganglioside that does not contain any sialidase-sensitive bonds.
openaire   +2 more sources

The effect of cholera toxin and cholera toxin B subunit on the nasal mucosal membrane

Vaccine, 1991
The effects of the self-adjuvanting substances, cholera toxin (CT) and cholera toxin B subunit (CTB), on rabbit nasal mucosal membrane, were investigated by using Ussing chambers. The control nasal mucosa (lateral wall), isolated from rabbits and mounted in the chamber, showed transepithelial potential difference, short-circuit current and conductance ...
S, Gizurarson, S, Tamura, T, Kurata, K, Hasiguchi, H, Ogawa   +4 more
openaire   +2 more sources