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The nature and action of cholera toxin.
Ciba Foundation symposium, 1977Cholera diarrhoea is due to the action of a toxin that acts on all animal cells by stimulating the enzyme adenylate cyclase, which catalyses the production oc cyclic AMP from ATP. In intestinal brush border cells raised cyclic AMP levels result in increased secretion of chloride ions, leading to fluid accumulation in the gut.
S van Heyningen +2 more
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Biochemical Society Transactions, 1981 Journal of Gastroenterology and Hepatology, 1994
Masahiro Yoshioka, Hitoshi Asakura
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Masahiro Yoshioka, Hitoshi Asakura
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Inhibition of Cholera Toxin by Brefeldin A
1993Many aspects of the mechanism of action of cholera toxin (CT), the causative agent of cholera are well established (Fishman, 1990). CT consists of a pentameric B subunit which binds to ganglioside G Ml on the cell surface and an A subunit which activates adenylyl cyclase.
Palmer A. Orlandi +2 more
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Regulation of Cholera Toxin Expression
2014This chapter focuses on composition and molecular mechanism of control of ToxR regulon. Early studies of the in vitro production of cholera toxin defined certain conditions that increased overall levels of cholera toxin. Early work on the genetics of cholera toxin expression relied heavily on the use of chemical mutagenesis to produce mutants altered ...
John J. Mekalanos, Karen M. Ottemann
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Biology and evolution of bacterial toxin–antitoxin systems
Nature Reviews Microbiology, 2022Nathan Fraikin +2 more
exaly