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Heterogeneity of purified cholera toxin
Biochimica et Biophysica Acta (BBA) - Protein Structure, 1977The heterogeneity of Vibrio cholerae toxin, obtained from culture filtrates in homogeneous form by gel filtration and preparative disc gel electrophoresis has been studied. By means of disc electrophoresis on polyacrylamide gel cholera toxin was separated into three forms designated I (5%), II (15%) and III (80%). The toxic activity, amino acid content
I. Luzzi +6 more
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Localization of Cholera Toxin In Vivo
Journal of Infectious Diseases, 1972Immunohistochemical techniques, done with fluorescein- and horseradish peroxidase-labeled antibodies specifically purified by immunoadsorption, were used to show cholera-toxin antigen in intestinal tissues from adult mice injected intraluminally with highly purified cholera toxin.
Richard A. Finkelstein +2 more
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Enzymatic and biological studies of cholera (Vibrio cholerae) toxin [PDF]
Experientia, 1971 Untersuchung der Enterotoxine vonVibrio cholerae auf eine Reihe von Enzymaktivitaten und im Hinblick auf die Aufklarung des pathogenetischen Mechanismus.
P. M. Toom, A. T. Tu
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On the similarity of tetanus and cholera toxins
Naunyn-Schmiedeberg's Archives of Pharmacology, 1973There are several similarities between tetanus and cholera toxins, including their ability to react with ganglioside. However, tetanus toxin reacts mostly with certain gangliosides containing sialidase-sensitive bonds, whereas cholera toxin reacts only with one particular ganglioside that does not contain any sialidase-sensitive bonds.
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The effect of cholera toxin and cholera toxin B subunit on the nasal mucosal membrane
Vaccine, 1991The effects of the self-adjuvanting substances, cholera toxin (CT) and cholera toxin B subunit (CTB), on rabbit nasal mucosal membrane, were investigated by using Ussing chambers. The control nasal mucosa (lateral wall), isolated from rabbits and mounted in the chamber, showed transepithelial potential difference, short-circuit current and conductance ...
Shin-ichi Tamura +4 more
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Annals of Tropical Paediatrics, 1986
Pure cholera toxin (CT) given as a booster in enteric-coated tablets to rats produced a humoral and intestinal immune response similar to the result of instilling the boosting dose of CT directly into the duodenum. This method protects the antigen against gastric acid and allows delivery of the immunogen to intestinal mucosa, an essential step in ...
Ian M. Watson +3 more
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Pure cholera toxin (CT) given as a booster in enteric-coated tablets to rats produced a humoral and intestinal immune response similar to the result of instilling the boosting dose of CT directly into the duodenum. This method protects the antigen against gastric acid and allows delivery of the immunogen to intestinal mucosa, an essential step in ...
Ian M. Watson +3 more
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Nanotransportation system for cholera toxin in Vibrio cholerae 01
Medical Molecular Morphology, 2009Vibrio cholerae (V. cholerae) cholera toxin (CT), which causes a severe watery diarrheal illness, is secreted via the type II secretion machinery; it remains unclear, however, how this toxin is transported toward the machinery. In this study, we determined that the pH-dependent intrabacterial transport system correlates with the priming of CT secretion
Takashi Nakano +7 more
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Glyconanoparticles for the Colorimetric Detection of Cholera Toxin
Analytical Chemistry, 2007Cholera continues to represent a major threat to human health, particularly in developing countries. Death can be readily avoided when medical treatment is rapidly administered. In order to provide a means of detecting the bacterially secreted toxin, we have developed a simple, yet rapid, bioassay for the cholera toxin.
Schofield, Claire L. +2 more
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Tracer-toxins: cholera toxin B-saporin as a model
Journal of Neuroscience Methods, 2000We have shown previously that retrogradely-transported cholera toxin B (CTB)-saporin has eliminated sympathetic preganglionic neurons by 7 days after injection (Llewellyn-Smith, I.J., Martin, C.L., Arnolda, L.F., Minson, J.B., 1999. NeuroReport 10, 307).
Llewellyn-Smith, Ida J +3 more
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The nature and action of cholera toxin.
Ciba Foundation symposium, 1977Cholera diarrhoea is due to the action of a toxin that acts on all animal cells by stimulating the enzyme adenylate cyclase, which catalyses the production oc cyclic AMP from ATP. In intestinal brush border cells raised cyclic AMP levels result in increased secretion of chloride ions, leading to fluid accumulation in the gut.
S van Heyningen +2 more
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