Results 61 to 70 of about 16,673 (222)

The Internal Nanostructure of Lipid Nanoparticles Influences Their Diverse Cellular Uptake Pathways

Small, Volume 21, Issue 40, October 9, 2025.
Lipid nanoparticles are vital for drug delivery, but their cellular interactions remain unclear. This study shows that non‐lamellar lyotropic liquid crystalline nanoparticles (LLCNPs) ‐ including cubosomes, hexosomes, and micellar cubosomes ‐ preferentially use passive pathways like membrane fusion, bypassing endocytic recycling faced by lamellar ...
Sue Lyn Yap, Brendan Dyett, Alison J. Hobro, Han Nguyen, Nicholas I. Smith, Calum J. Drummond, Charlotte E. Conn, Nhiem Tran   +7 more
wiley   +1 more source

An overview of VaxchoraTM, a live attenuated oral cholera vaccine

Human Vaccines & Immunotherapeutics, 2020
Cholera remains a public health threat among the least privileged populations and regions affected by conflicts and natural disasters. Together with Water, Sanitation and Hygiene practices, use of oral cholera vaccines (OCVs) is a key tool to prevent ...
Tarun Saluja, Vijayalaxmi V. Mogasale, Jean-Louis Excler, Jerome H. Kim, Vittal Mogasale   +4 more
doaj   +1 more source

PaxVax CVD 103-HgR single-dose live oral cholera vaccine

Expert Review of Vaccines, 2017
Introduction: Cholera remains a problem in developing countries and a risk for travelers. Hypochlorhydria, blood group O, cardiac and renal disease increase the risk of developing cholera gravis.
Myron M. Levine, Wilbur H. Chen, James B. Kaper, Michael Lock, Lisa Danzig, Marc Gurwith   +5 more
doaj   +1 more source

Cholera - The Grim Reality of Under-development

South African Family Practice, 2001
Cholera is a severe diarrhoeal illness caused by certain strains of Vibrio cholerae, which can lead rapidly to dehydration and death. Communities dependent on water contaminated with human faeces and those with poor sanitation are very vulnerable to ...
D.N. Durrheim, G.A. Ogunbanjo, L. Blumberg, K.H. Keddy   +3 more
doaj   +1 more source

Controlling cholera in the Ouest Department of Haiti using oral vaccines. [PDF]

PLoS Neglected Tropical Diseases, 2017
Following the 2010 cholera outbreak in Haiti, a plan was initiated to provide massive improvements to the sanitation and drinking water infrastructure in order to eliminate cholera from the island of Hispaniola by 2023.
Alexander Kirpich, Thomas A Weppelmann, Yang Yang, John Glenn Morris, Ira M Longini   +4 more
doaj   +1 more source

Dissolving Microneedle for Maintaining the Integrity of HPV Virus‐Like Particles Enabling Durable Sterile Protection Across Various Mucosal Tissues

Advanced Healthcare Materials, Volume 14, Issue 24, September 18, 2025.
A novel dissolving microneedle platform preserves HPV virus‐like particle (VLP) immunogenicity by maintaining structural integrity, crucial for eliciting potent immune responses. Buccal administration induces robust immune response, high neutralizing antibody titers, and durable sterile protection across oral and vaginal mucosal sites.
Hyemi Kim, Inhyuk Hwang, Juhee Seo, Chaiwon Kim, In‐Jeong Choi, Miran Kang, Min‐Seok Rha, Youngjae Hong, Jooyoung Kim, Seung‐Ki Baek, Jung‐Hwan Park, Hyung‐Ju Cho, Kihyuck Kwak   +12 more
wiley   +1 more source

Outer Membrane Vesicles as a Versatile Platform for Vaccine Development: Engineering Strategies, Applications and Challenges

Journal of Extracellular Vesicles, Volume 14, Issue 9, September 2025.
ABSTRACT Outer membrane vesicles (OMVs) are nanosized vesicles naturally secreted by Gram‐negative bacteria and represent a promising platform for vaccine development. OMVs possess inherent immunostimulatory properties due to the presence of pathogen‐associated molecular patterns (PAMPs), providing self‐adjuvanting capabilities and the ability to ...
Asja Garling, Frédéric Auvray, Mathieu Epardaud, Éric Oswald, Priscilla Branchu   +4 more
wiley   +1 more source

Mapping the high burden areas of cholera in Nepal for potential use of oral cholera vaccine: An analysis of data from publications and routine surveillance systems

Asian Pacific Journal of Tropical Medicine, 2020
Objective: To assess the extent of existing published evidence on cholera and to characterize the epidemiologic data of cholera in Nepal. Methods: We conducted a literature scoping review by summarizing published literature reporting on cholera in Nepal ...
Chulwoo Rhee, Birendra Prasad Gupta, Bibek Kumar Lal, Jacqueline Kyungah Lim, T Anh Wartel, Julia Lynch, Sushant Sahastrabuddhe   +6 more
doaj   +1 more source

Understanding the Enigmatic Dance of Immune‐Mediated Viral Infections and Their Pathogenetic Mechanisms

Veterinary Medicine and Science, Volume 11, Issue 5, September 2025.
This graphical representation illustrates the multifaceted nature of the immune response in viral infections, demonstrating both its protective and potentially harmful aspects. While a properly regulated immune reaction facilitates viral clearance and promotes general recovery, an overly robust or misdirected response—exemplified by Type III or Type IV
Muhammed Cesim Karabulut, Tuba Çiğdem Oğuzoğlu   +1 more
wiley   +1 more source

Considerations for Oral Cholera Vaccine Use during Outbreak after Earthquake in Haiti, 2010−2011

Emerging Infectious Diseases, 2011
Oral cholera vaccines (OCVs) have been recommended in cholera-endemic settings and preemptively during outbreaks and complex emergencies. However, experience and guidelines for reactive use after an outbreak has started are limited. In 2010, after over a
Kashmira A. Date, Andrea Vicari, Terri B. Hyde, Eric D. Mintz, M. Carolina Danovaro-Holliday, Ariel Henry, Jordan W. Tappero, Thierry H. Roels, Joseph Abrams, Brenton T. Burkholder, Cuauhtémoc Ruiz-Matus, Jon Andrus, Vance Dietz   +12 more
doaj   +1 more source