Results 71 to 80 of about 35,648 (268)

Pandemic Vibrio cholerae and the Environmental Reservoir Hypothesis—Outstanding Questions Central to Global Cholera Control

Environmental Microbiology, Volume 28, Issue 5, May 2026.
Whether, when and for how long pandemic Vibrio cholerae forms long‐term environmental reservoirs remains uncertain. We propose a new framework to evaluate possible mechanisms by which the pathogen might experience reservoir formation versus environmental elimination.
Azfar D. Hossain, William P. Robins, John J. Mekalanos, Louise C. Ivers   +3 more
wiley   +1 more source

Why, Immunologically, Housing‐Related Fungi and Endotoxins (and Other Chronic Pro‐Inflammatory Stressors) Risk Latent Tuberculosis Reactivation, Severe Asthma, and Translocating and Invasive Infections in Indigenous Communities in Canada

American Journal of Human Biology, Volume 38, Issue 4, April 2026.
ABSTRACT Type 1/M1/TH1 and type 3/M1/TH17 pro‐inflammatory switches are risks for latent Mycobacterium tuberculosis (Mtb) reactivation and ongoing infection transmission. This paper considers the heavy toll of reactivation risk in Indigenous communities in Canada and the chronic, everyday pro‐inflammatory stressors connected with type 3/M1/TH17 immune ...
Stacie Burke
wiley   +1 more source

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, Volume 6, Issue 4, April 2026.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

Use of oral cholera vaccine as a vaccine probe to define the geographical dimensions of person-to-person transmission of cholera

International Journal of Infectious Diseases, 2018
Background: Cholera is known to be transmitted from person to person, and inactivated oral cholera vaccines (OCVs) have been shown to confer herd protection via interruption of this transmission.
Mohammad Ali, Deok Ryun Kim, Suman Kanungo, Dipika Sur, Byomkesh Manna, Laura Digilio, Shanta Dutta, Florian Marks, Sujit K. Bhattacharya, John Clemens   +9 more
doaj   +1 more source

Psychological Distress, Fatigue, and Post‐Traumatic Stress Disorder Among Medical Staff Facing the Acute Watery Diarrhea Outbreak in Syria, Difficulties and Solutions: A Mixed‐Methods Study

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background Cholera continues to be a significant public health threat, particularly in underserved regions with overcrowding and poor sanitation. The 2022–2023 cholera outbreak in Syria, particularly in Aleppo, overwhelmed medical staff, who faced extreme stress, extended work hours, and department closures. This cross‐sectional study examines
Ahmad Yamen Arnaout, Abdallah Aladna, Hassan Alshaker, Muhammad Besher Shabouk, Ibrahim Arnaout, Omar Najjar   +5 more
wiley   +1 more source

PaxVax CVD 103-HgR single-dose live oral cholera vaccine

Expert Review of Vaccines, 2017
Introduction: Cholera remains a problem in developing countries and a risk for travelers. Hypochlorhydria, blood group O, cardiac and renal disease increase the risk of developing cholera gravis.
Myron M. Levine, Wilbur H. Chen, James B. Kaper, Michael Lock, Lisa Danzig, Marc Gurwith   +5 more
doaj   +1 more source

An Engineered Nano‐Vesicle Adjuvant Platform (ENAP) for Cytokine Delivery Enables a Novel Antigen‐Coordinated Vaccine Against Helicobacter pylori

Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
ABSTRACT Despite the considerable potential of Helicobacter pylori (H. pylori) vaccines, their clinical efficacy has been hampered by inadequate mucosal immunity and suboptimal Th1/Th17 polarization. To address this, we engineered a novel nano‐adjuvant system using LPS‐modified recombinant outer membrane vesicles (rOMVs) derived from H.
Yinpan Shang, Xiran Zhang, Linwei Li, Xiaomin Yu, Lingbing Zeng, Yanli Cao, Ziwei Tao, Lu Shen, Shuaishuai Zhang, Chuangye Yang, Huizhen Tian, Ying Liang, Hanchen Liao, Xiaotian Huang, Qiong Liu   +14 more
wiley   +1 more source

Leaf-Encapsulated Vaccines: Agroinfiltration and Transient Expression of the Antigen Staphylococcal Endotoxin B in Radish Leaves. [PDF]

, 2018
Transgene introgression is a major concern associated with transgenic plant-based vaccines. Agroinfiltration can be used to selectively transform nonreproductive organs and avoid introgression.
Gallo, Richard L, Huang, Chun-Ming, Liu, Pei-Feng, Simmons, Christopher W, Ulrich, Robert G, VanderGheynst, Jean S, Wang, Yanhan   +6 more
core   +3 more sources

Beyond Rotavirus: Persistence of Norovirus, Adenovirus, and Astrovirus in Paediatric Gastroenteritis in the Republic of Congo After Vaccine Introduction

Journal of Medical Virology, Volume 98, Issue 4, April 2026.
ABSTRACT Despite the introduction of rotavirus vaccines, gastroenteritis remains a major cause of paediatric morbidity and mortality in the Republic of Congo. This study investigated the prevalence and genetic diversity of non‐rotavirus enteric viruses including norovirus (NoV), adenovirus (AdV), and astrovirus (AstV) ten years after the introduction ...
Cedeche Lebraiche Durain Mboungou, Claujens Chastel Mfoutou Mapanguy, Do Duc Anh, Jeannhey Christevy Vouvoungui, Alain Maxime Mouanga, Vivaldie Mikounou Louya, Emmanuel Seun Kupoluyi, Raoul Ampa, Thirumalaisamy P. Velavan, Francine Ntoumi   +9 more
wiley   +1 more source

Cholera - The Grim Reality of Under-development

South African Family Practice, 2001
Cholera is a severe diarrhoeal illness caused by certain strains of Vibrio cholerae, which can lead rapidly to dehydration and death. Communities dependent on water contaminated with human faeces and those with poor sanitation are very vulnerable to ...
D.N. Durrheim, G.A. Ogunbanjo, L. Blumberg, K.H. Keddy   +3 more
doaj   +1 more source