Results 51 to 60 of about 514 (159)

Treatment of Inborn Errors by Product Replacement: The Example of Inborn Errors of Bile Acid Synthesis

open access: yesJournal of Inherited Metabolic Disease, Volume 48, Issue 5, September 2025.
ABSTRACT Many inborn errors of metabolism affect pathways involved in the synthesis of a metabolite that has an important biochemical or physiological function, and adverse effects of the disorder can be attributed to the lack of this metabolite. Thus, there is the opportunity for treatment by ‘product replacement’. One of the disorders in the pathways
Peter T. Clayton   +2 more
wiley   +1 more source

Molecular and isotopic signatures of life surrounding the Neoproterozoic Snowball Earth events [PDF]

open access: yes, 2017
Life on Earth transitioned from being mainly dominated by bacteria prior to the Cryogenian Snowball Earth events (717a 635 Ma) to an ecosystem in which biologically more complex eukaryotes (e.g.
Van Maldegem, Lennart Martijn
core  

Exogenous oxidized phytosterol may modulate linoleic acid metabolism through upregulation of fatty acid desaturase in rats

open access: yesLipids, Volume 60, Issue 5, Page 303-315, September 2025.
Abstract Previous in vitro studies have indicated that oxidized phytosterol (OPS) exhibits some toxicity; however, the harmful effects of OPS on fatty acid metabolism are not completely understood yet. Therefore, this study examined the effects of exogenous phytosterol (PS) and OPS on growth parameters and lipid metabolism in rats.
Tomonari Koyama, Kyoichi Osada
wiley   +1 more source

Paleoenvironmental conditions, source and maturation of Neogene organic matter from the siliciclastic deposits of the Orava-Nowy Targ Basin [PDF]

open access: yes, 2018
The Orava-Nowy Targ Basin (ONTB) is an intramontane depression filled with Neogene and Quaternary deposits located at the junction of the Inner and Outer Carpathians. The Neogene infill of the basin consists mainly of siliciclastic rocks with very common
Bojanowski, Maciej   +4 more
core   +1 more source

Fecal Biomarkers in Soils Record Landscape‐Scale Wild Herbivore Abundance

open access: yesGeochemistry, Geophysics, Geosystems, Volume 26, Issue 9, September 2025.
Abstract In Earth history, our understanding of how large‐bodied herbivores shape a variety of ecosystem processes is limited by the quality of paleoecological proxies for herbivore composition and abundance. Fecal stanols are lipids that can be produced by microbes within animal digestive systems and that could remedy this dearth of proxies.
A. Tyler Karp   +4 more
wiley   +1 more source

Mineralization Controls Informative Biomarker Preservation Associated With Soft Part Fossilization in Deep Time

open access: yesGeobiology, Volume 23, Issue 5, September/October 2025.
ABSTRACT Diagenetically mineralized fossil tissues represent invaluable paleobiological evidence of past life. Lipid biomarkers may be identified alongside fossils, yet the relationship between localized, diagenetic mineral precipitation, and lipid preservation remains underexplored.
Madison Tripp   +7 more
wiley   +1 more source

The clarification of two hydroxylation steps in the conversion of cholesterol to OSW‐1 in Ornithogalum saundersiae

open access: yesPlant Biotechnology Journal, Volume 23, Issue 9, Page 4030-4043, September 2025.
Summary OSW‐1 is a cholestane saponin uniquely produced in Ornithogalum saundersiae and exhibits a potential antitumor activity. The enzymes responsible for OSW‐1 biosynthesis in O. saundersiae, however, remain unclear. Herein, cholesterol was confirmed to be the precursor of OSW‐1 using stable‐isotope labeling method.
Shu‐Yue Zhang, Jian‐Qiang Kong
wiley   +1 more source

Vitamin D supplementation in a post-pandemic era: A narrative review. [PDF]

open access: yesS Afr Fam Pract (2004), 2023
Bopape PG   +3 more
europepmc   +1 more source

The competitive acylation and sulphonylation of amines [PDF]

open access: yes, 1980
Imperial Users ...
Toghraie, S., Toghraie, S.
core  

ANTIMYCOBACTERIAL COMPOUNDS FROM NASTURTIUM OFFICINALE [PDF]

open access: yes, 2016
Background: Nasturtium officinale is a plant used in Mexican traditional medicine to treat respiratory infections such as tuberculosis. In previous studies, it was found that the chloroform extract of the aerial parts of N.
Alvarez, Laura   +5 more
core   +3 more sources

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