On the stereospecificity of cholestanetriol 26-monooxygenase.
Both diastereoisomers, 5 beta-cholestane-3 alpha, 7 alpha, 12 alpha, 26-tetrol (25S isomer) and 5 beta-cholestane-3 alpha, 7 alpha, 12 alpha, 27-tetrol (25R isomer), were chemically synthesized, and the method to separate these epimers by thin layer chromatography was established.
Y, Atsuta, K, Okuda
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Phenoconversion of cytochrome P450 metabolism: a systematic review [PDF]
Phenoconversion is the mismatch between the individual's genotype-based prediction of drug metabolism and the true capacity to metabolize drugs due to nongenetic factors.
Guchelaar, H.J. +3 more
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Transcriptome Analysis in Tardigrade Species Reveals Specific Molecular Pathways for Stress Adaptations [PDF]
Tardigrades have unique stress-adaptations that allow them to survive extremes of cold, heat, radiation and vacuum. To study this, encoded protein clusters and pathways from an ongoing transcriptome study on the tardigrade Milnesium tardigradum were ...
Beisser, Daniela +13 more
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Systemorientierte Analysen von hepatischen 13C-Markierungs- und Stoffwechseldynamiken [PDF]
In this thesis a data-driven model-based approach was undertaken to analyze the liver central metabolism at the systems-level. The work focused on the model-assisted interpretation of metabolome and fluxome data.
Maier, Klaus
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Transcriptomic Analysis of synthetic steroid tibolone against a lipotoxic Insult with palmitic acid in normal human astrocytes [PDF]
La obesidad genera la acumulación de diferentes lípidos en el organismo, entre ellos el ácido palmítico (AP). Este es es el ácido graso más abundante en el cuerpo humano y su cumulación excesiva ha sido ligada a la progresión de diferentes enfermedades ...
Martin Jimenez, Cynthia Alexandra
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Prediction of Anti-Hiv Activity of Flavanoid Constituents Through PASS [PDF]
Prediction of Activity Spectra for Substances (PASS), a new computer program, has been generated to evaluate the biological activity of four major flavanoids from a medicinal herb, Boesenbergia pandurata Holtt. (Zingiberaceae).
Maridass, Muthiah, et al.
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Validation of a liver cell model for studies on the effects of some micro-food components on antioxidant defense [PDF]
The development of m vitro models for toxicity testing of food components is dependent on the availability of standardized methods of cell isolation, preparation and culture.
Cantwell, Helen
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Cholesterol oxidation products : analytical methods and levels in sweets containing heated butter oil [PDF]
Various methods are used to analyse cholesterol oxidation products (COP) due to the unavailability of a standard method. In order to select a suitable method for the enrichment of COP, three methods of saponication (A – C),and transesterication (D) of
Ubhayasekera, Sarojini Jayantha Kumari
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