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The metabolism of cholestanol in primary biliary cirrhosis
Journal of Hepatology, 1996The concentration of serum cholestanol, a 5 alpha-saturated derivative of cholesterol, is increased in primary biliary cirrhosis proportionally to impaired liver function for unknown reasons. The purpose of this study was to analyze serum cholestanol level and its biliary and fecal elimination, and relate the results to cholesterol absorption and ...
H, Gylling +3 more
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Chromatographic separation of putative precursors of cholestanol
Steroids, 1988This paper describes convenient syntheses for labeled and unlabeled cholest-5-en-3-one, cholest-4-en-3-one, epicholesterol, cholest-4-en-3 beta-ol, and cholest-4-en-3 alpha-ol. The thin-layer chromatography, high-performance liquid chromatography, and gas-liquid chromatography of these compounds and of cholestanol and epicholestanol are also described.
A K, Batta, G, Salen, S, Shefer
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Prevention of Cholestanol-induced Cholelithiasis by Neomycin
Nature, 1965RABBITS receiving 0.25–1 per cent dietary cholestanol (5α-cholestan-3β-ol) for 3–6 weeks develop gall-stones which have been shown to consist predominantly of calcium, and sodium glycoallodeoxycholate (3α-, 12α-dihydroxy-5α-cholanoyl glycine)1,2. Gall-stone formation in cholestanol-fed rabbits has been postulated to occur as follows: Cholestanol is ...
E H, Mosbach +5 more
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Analysis of sterol extracts for cholestanol
Analytical Biochemistry, 1965Abstract Cholestanol analyses of sterols have been carried out by removal of the unsaturated sterols by oxidation and extraction followed by gas chromatography of the saturated sterols. The method can detect 0.2% of cholestanol in sterol mixtures.
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Squalene and cholestanol in normal rabbit aorta
Atherosclerosis, 1970Abstract Squalene and cholestanol were isolated from normal rabbit aortic tissue, identified and quantitatively determined. The concentration of squalene and cholestanol was 4.5 and 7.7 mg respectively, in 100 g of dry, delipidized tissue.
V, Stefanovich, G, Kajiyama
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Cholestanol Induces Apoptosis of Cerebellar Neuronal Cells
Biochemical and Biophysical Research Communications, 1999Cerebrotendinous xanthomatosis (CTX) is a hereditary lipid storage disease characterized by hyper-cholestanolemia, cerebellar ataxia, xanthoma, and cataract. We hypothesized that cholestanol in serum of CTX patients might induce neuronal cell death in the cerebellum and eventually lead to cerebellar ataxia.
K, Inoue, S, Kubota, Y, Seyama
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Effects of cholestanol feeding on corneal dystrophy in mice
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1991A cholestanol-enriched diet administered for 8 months to BALB/c mice produced in 20% two kinds of corneal opacities resembling calcific band keratopathy and Schnyder's crystalline dystrophy in humans. The concentrations of cholestanol in serum, liver and cornea of the corneal opacity bearing mice were 30-40-times higher than those of normal mice.
K S, Kim +5 more
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Association of cholestanol and cholestanone with lysophosphatidylcholine
Chemistry and Physics of Lipids, 1984Abstract On sonication in water, cholestanol and lysophosphatidylcholine (lysoPC) in 1:1 molar ratio form unilamellar vesicles which are similar to lysoPC/cholesterol vesicles, as judged by gel exclusion chromatography, electron microscopy, and differential thermal scanning.
L.S. Ramsammy, P.A. Merz, H. Brockerhoff
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Cholestanol and plant sterols in pigeon skin
Lipids, 1973AbstractCholestanol (4.6%) and plant sterols (0.2%) have been demonstrated, for the first time, in avian skin by argentation and gas liquid chromatography. In contrast to results of previous studies with rat and human skin, cholestanol represented a significant amount in the pigeon.
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Effect of Vagotomy on Cholestanol Cholelithogenesis in the Rabbit
Investigative Radiology, 1968The effect of bilateral truncal vagotomy on the gallbladder of the rabbit was studied. Up to twenty-four weeks, no significant spontaneous cholelithogenesis appeared. When vagotomized rabbits were given sublithogenic doses of cholestanol, gallstones formed in 50%.
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