Results 31 to 40 of about 107,736 (386)

Serum bile acids as a prognostic biomarker in biliary atresia following Kasai portoenterostomy

Hepatology, EarlyView., 2022
Serum bile acid levels predict outcomes in patients with biliary atresia who achieve normalized bilirubin levels after Kasai portoenterostomy. Abstract Background and Aims In biliary atresia, serum bilirubin is commonly used to predict outcomes after Kasai portoenterostomy (KP).
Sanjiv Harpavat, Kieran Hawthorne, Kenneth D. R. Setchell, Monica Narvaez Rivas, Lisa Henn, Charlotte A. Beil, Saul J. Karpen, Vicky L. Ng, Estella M. Alonso, Jorge A. Bezerra, Stephen L. Guthery, Simon Horslen, Kathy M. Loomes, Patrick McKiernan, John C. Magee, Robert M. Merion, Jean P. Molleston, Philip Rosenthal, Richard J. Thompson, Kasper S. Wang, Ronald J. Sokol, Benjamin L. Shneider, for Childhood Liver Disease Research Network (ChiLDReN)   +22 more
wiley   +1 more source

Cholestasis

Veterinary Clinics of North America: Small Animal Practice, 1985
Cholestasis can be caused by extrahepatic and intrahepatic pathogenic mechanisms that affect cellular and subcellular functions. The retention of bile results in numerous biochemical abnormalities, some of which are useful as clinical tests. The clinicopathologic findings are often suggestive of the underlying hepatobiliary disorder but are seldom ...
Associate Professor, Department of Medical Sciences, University of Florida College of Veterinary Medicine, Gainesville, FloridaDepartment of Medical SciencesUniversity of Florida College of Veterinary MedicineGainesvilleFlorida ( host institution ), Meyer, D.J., Chiapella, A.M.   +2 more
openaire   +3 more sources

Tauroursodeoxycholic acid exerts anticholestatic effects by a cooperative cPKC alpha-/PKA-dependent mechanism in rat liver. [PDF]

, 2008
Objective: Ursodeoxycholic acid (UDCA) exerts anticholestatic effects in part by protein kinase C (PKC)-dependent mechanisms. Its taurine conjugate, TUDCA, is a cPKCa agonist.
Beuers, U., Denk, G.U., Hohenester, S., Pusl, T., Rust, C., Wimmer, R.   +5 more
core   +1 more source

Molecular overview of progressive familial intrahepatic cholestasis

World Journal of Gastroenterology, 2020
Cholestasis is a clinical condition resulting from the imapairment of bile flow. This condition could be caused by defects of the hepatocytes, which are responsible for the complex process of bile formation and secretion, and/or caused by defects in the ...
Sriram Amirneni, N. Haep, M. A. Gad, A. Soto‐Gutierrez, J. Squires, R. Florentino   +5 more
semanticscholar   +1 more source

Compound Heterozygous MYO5B Mutation, a Cause of Infantile Cholestasis: A Case Report

Journal of Nepal Medical Association, 2022
Infantile cholestasis is a common clinical problem in early infancy characterised by impairment in bile formation and/or flow. It requires prompt evaluation for underlying aetiology to initiate appropriate management.
Muna Khanal, Adarsh Kumar Jha, Arun Kumar Sharma   +2 more
doaj   +1 more source

Modulation of the unfolded protein response by tauroursodeoxycholic acid counteracts apoptotic cell death and fibrosis in a mouse model for secondary biliary liver fibrosis [PDF]

, 2017
The role of endoplasmic reticulum stress and the unfolded protein response (UPR) in cholestatic liver disease and fibrosis is not fully unraveled. Tauroursodeoxycholic acid (TUDCA), a hydrophilic bile acid, has been shown to reduce endoplasmic reticulum (
Bogaerts, Eliene, Colle, Isabelle, Devisscher, Lindsey, Geerts, Anja, Hoorens, Anne, Paridaens, Annelies, Raevens, Sarah, van Grunsven, Leo, Van Vlierberghe, Hans, Verhelst, Xavier   +9 more
core   +2 more sources

Benign recurrent intrahepatic cholestasis

Definitions, 2020
Benign recurrent intrahepatic cholestasis (BRIC) is characterized by episodes of liver dysfunction called cholestasis. During these episodes, the liver cells have a reduced ability to release a digestive fluid called bile.
Alexander K. C. Leung, M. Schmitt, Christie P. Thomas, Cord Sunderkötter, M. Schiller, Thomas Schwarz, M. Berneburg, A. Kohlschütter, Lorenzo Cerroni, H. Direşkeneli, Kenneth Calamia, Gloria L. David, D. Zeldin, B. Schütte, Lee A. Denson, Andreas Erhardt, Ralf Kubitz, D. Häussinger, W. Sealey, Donald M. Mock, Barry Wolf, Johannes Schumacher, Peter Propping, D. Metze, Andrew L. Wong, M. Hengstschläger, Whitney A. High, Kenneth R. Shroyer, M. E. Mccready, Dennis E. Bulman, Ali R. Afzal, David B. Everman, C. Stoll, S. Darcan, Y. Kou, You Shuei Lin, Yoichi Suzuki, Keiya Tada, S. Kupka, Wolfgang Dietmaier, Arndt Hartmann, R. Hennekam, J. Belperio, Michael P. Keane, M. Iain Smith, Robert M. Strieter, Nestor A. Molfino, F. Sciandra, T. Rossenbacker, S. Priori, Marco Senzolo, Christos Triantos, Dimitrios Samonakis, E. Cholongitas, A. Burroughs, Marco Mura, Markus Braun-Falco, S. Hofmann, Leena Bruckner‐Tuderman   +58 more
semanticscholar   +1 more source

Outcomes of 38 patients with PFIC3: Impact of genotype and of response to ursodeoxycholic acid therapy

JHEP Reports, 2023
Background & Aims: Progressive familial intrahepatic cholestasis type 3 (PFIC3) is a rare liver disease caused by biallelic variations in ABCB4. Data reporting on the impact of genotype and of response to ursodeoxycholic acid (UDCA) therapy on long ...
Emmanuel Gonzales, Antoine Gardin, Marion Almes, Amaria Darmellah-Remil, Hanh Seguin, Charlotte Mussini, Stéphanie Franchi-Abella, Mathieu Duché, Oanez Ackermann, Alice Thébaut, Dalila Habes, Bogdan Hermeziu, Martine Lapalus, Thomas Falguières, Jean-Philippe Combal, Bernard Benichou, Sonia Valero, Anne Davit-Spraul, Emmanuel Jacquemin   +18 more
doaj  

Decreased expression of breast cancer resistance protein in the duodenum in patients with obstructive cholestasis [PDF]

, 2006
Background/Aims: The expression of transporters involved in bile acid homeostasis is differentially regulated during obstructive cholestasis. Since the drug efflux transporter breast cancer resistance protein (BCRP) is known to transport bile acids, we ...
Adachi Y, Brendel C, Christian Zimmermann, Christoph Beglinger, Denk GU, Denson LA, Dietrich CG, Dietrich CG, Ee PL, Frank Lehmann, Freeman LA, Geier A, Gutmann H, Heike Gutmann, Hruz P, Imai Y, Janvilisri T, Jonker JW, Juergen Drewe, Jung D, Jung D, Kamisako T, Klucken J, Li N, Lown KS, Lu TT, Luigi Terracciano, Maliepaard M, Miyake K, Petr Hruz, Plebani M, Popowski K, Schellens JH, Smith M, Stedman CA, Stellaard F, Suzuki M, Taipalensuu J, Tanaka Y, Tanaka Y, Trauner M, Ulrich Beuers, van Herwaarden AE, Volk EL, Wagner M, Xie W, Yu L, Zimmermann C, Zollner G   +48 more
core   +1 more source

A Complex Case of Cholestasis in a Patient with ABCB4 and ABCB11 Mutations [PDF]

, 2018
The low-phospholipid-associated cholelithiasis (LPAC) syndrome is a form of symptomatic cholelithiasis occurring in young adults, characterized by recurrence of symptoms after cholecystectomy and presence of hepatolithiasis.
Anapaz, V, Branco, J, Cardoso, M, Carvalho, R, Horta, D, Martins, A, Reis, J, Rodrigues, C   +7 more
core   +1 more source