Results 41 to 50 of about 113,305 (364)

Synthesis, in vitro and in vivo evaluation of 3β-[18F]fluorocholic acid for the detection of drug-induced cholestasis in mice [PDF]

, 2017
Introduction : Drug-induced cholestasis is a liver disorder that might be caused by interference of drugs with the hepatobiliary bile acid transporters. It is important to identify this interference early on in drug development.
De Lombaerde, Stef, De Vos, Filip, Devisscher, Lindsey, Kersemans, Ken, Neyt, Sara, Van Vlierberghe, Hans, Vanhove, Christian, Verhoeven, Jeroen   +7 more
core   +3 more sources

A novel homozygous mutation in the USP53 gene as the cause of benign recurrent intrahepatic cholestasis in children: a case report

The Turkish Journal of Pediatrics, 2023
Background. Benign recurrent intrahepatic cholestasis (BRIC) is a rare cause of cholestasis with recurrent episodes of jaundice and pruritus without extrahepatic bile duct obstruction.
Burcu Berberoğlu Ateş, Ahmet Cevdet Ceylan, Gülin Hızal, Fatih Duran, Hayriye Tatlı Doğan, Şamil Hızlı   +5 more
doaj   +1 more source

Cholestasis [PDF]

Gut, 2003
In contrast with urine formation, bile flow is not dependent on hydrostatic forces, but driven by osmotic pressure of solutes secreted across the apical membrane of hepatocytes and bile duct epithelial cells. This secretory process is mediated by a set of primary active transporters that use ATP hydrolysis to pump solutes against the concentration ...
openaire   +3 more sources

Intrahepatic Cholestasis in Pregnancy: Review of the Literature

Journal of Clinical Medicine, 2020
Intrahepatic cholestasis of pregnancy (ICP) is the most common hepatic disorder related to pregnancy in women. It usually develops within the third trimester of pregnancy and presents with pruritus as well as elevated levels of bile acid and/or alanine ...
Joanna Piechota, W. Jelski
semanticscholar   +1 more source

A Complex Case of Cholestasis in a Patient with ABCB4 and ABCB11 Mutations [PDF]

, 2018
The low-phospholipid-associated cholelithiasis (LPAC) syndrome is a form of symptomatic cholelithiasis occurring in young adults, characterized by recurrence of symptoms after cholecystectomy and presence of hepatolithiasis.
Anapaz, V, Branco, J, Cardoso, M, Carvalho, R, Horta, D, Martins, A, Reis, J, Rodrigues, C   +7 more
core   +1 more source

Cholestasis

Veterinary Clinics of North America: Small Animal Practice, 1985
Cholestasis can be caused by extrahepatic and intrahepatic pathogenic mechanisms that affect cellular and subcellular functions. The retention of bile results in numerous biochemical abnormalities, some of which are useful as clinical tests. The clinicopathologic findings are often suggestive of the underlying hepatobiliary disorder but are seldom ...
Associate Professor, Department of Medical Sciences, University of Florida College of Veterinary Medicine, Gainesville, FloridaDepartment of Medical SciencesUniversity of Florida College of Veterinary MedicineGainesvilleFlorida ( host institution ), Meyer, D.J., Chiapella, A.M.   +2 more
openaire   +3 more sources

Molecular overview of progressive familial intrahepatic cholestasis

World Journal of Gastroenterology, 2020
Cholestasis is a clinical condition resulting from the imapairment of bile flow. This condition could be caused by defects of the hepatocytes, which are responsible for the complex process of bile formation and secretion, and/or caused by defects in the ...
Sriram Amirneni, Nils Haep, M. A. Gad, A. Soto‐Gutierrez, J. Squires, R. Florentino   +5 more
semanticscholar   +1 more source

Bile Acid Receptor Therapeutics Effects on Chronic Liver Diseases [PDF]

, 2020
In the past ten years, our understanding of the importance of bile acids has expanded from fat absorption and glucose/lipid/energy homeostasis into potential therapeutic targets for amelioration of chronic cholestatic liver diseases.
Alpini, Gianfranco, Francis, Heather, Kennedy, Lindsey, Kundu, Debjyoti, Meadows, Vik   +4 more
core   +1 more source

Recreational exposure during algal bloom in carrasco beach, uruguay: A liver failure case report [PDF]

, 2017
In January 2015, a 20-month-old child and her family took part in recreational activities at Carrasco and Malvín beaches (Montevideo, Uruguay). An intense harmful algae bloom (HAB) was developing along the coast at that time.
Andrinolo, Dario, Caixach, Josep, Cavalieri, María Lorena, D'Agostino, Daniel, Flores, Cintia, Mullen, Eduardo, Parot Varela, María Macarena, Sedan, Daniela Yazmine, Vidal, Flavia   +8 more
core   +3 more sources

Cholestasis: human disease and experimental animal models

Annals of Hepatology, 2003
Cholestasis may result from a failure in bile secretion in hepatocytes or ductular cells, or from a blockade to the free bile flow. Human cholestasis may be induced by many drugs, being antibiotics the more common.
Emilio Alberto Rodríguez-Garay, MD, PhD
doaj   +1 more source