Results 1 to 10 of about 33,745 (208)
Up to date on cholesterol 7 alpha-hydroxylase (CYP7A1) in bile acid synthesis [PDF]
Liver Research, 2020 Cholesterol 7 alpha-hydroxylase (CYP7A1, EC1.14) is the first and rate-limiting enzyme in the classic bile acid synthesis pathway. Much progress has been made in understanding the transcriptional regulation of CYP7A1 gene expression and the underlying ...
John Y.L. Chiang, Jessica M. Ferrell
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Favorable effects of Anethum graveolens on liver oxidative stress and cholesterol 7 alpha-hydroxylase levels in non-alcoholic fatty liver disease (NAFLD) rat models [PDF]
Metabolism Open, 2021 Background: High-fat high-cholesterol diet induces a phenotype similar to non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) in humans.
Ebrahim Abbasi +4 more
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Cholesterol 7 alpha-hydroxylase (CYP7A1) gene polymorphisms are associated with increased LDL-cholesterol levels and the incidence of subclinical atherosclerosis [PDF]
Biomolecules & BiomedicineThe cholesterol 7 alpha-hydroxylase (CYP7A1) enzyme plays an important role in the conversion of cholesterol to bile acid, contributing to the reduction of cholesterol plasma levels in normal conditions.
Gilberto Vargas-Alarcón +3 more
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Journal of Biological Chemistry, 1990 Monospecific antibody against purified rat liver cholesterol 7 alpha-hydroxylase cytochrome P-450 was used to screen a lambda gt11 cDNA library constructed from immuno-enriched polysomal RNA of cholestyramine-treated female rat liver.
Y. Li, D. P. Wang, J. Chiang
semanticscholar +3 more sources
Thyroid hormone induction of human cholesterol 7 alpha-hydroxylase (Cyp7a1) in vitro. [PDF]
Mol Cell Endocrinol, 2014 Thyroid hormone (TH) modulates serum cholesterol by acting on TH receptor β1 (TRβ1) in liver to regulate metabolic gene sets. In rodents, one important TH regulated step involves induction of Cyp7a1, an enzyme in the cytochrome P450 family, which enhances cholesterol to bile acid conversion and plays a crucial role in regulation of serum cholesterol ...
Lammel Lindemann JA +4 more
europepmc +4 more sources
Journal of Biological Chemistry, 1990 Two cholesterol 7 alpha-hydroxylase isozymes were purified from liver microsomes of cholestyramine-treated female rats by using anion exchange high performance liquid chromatography.
J. Chiang, W. F. Miller, G. Lin
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Rat liver cholesterol 7 alpha-hydroxylase. Pretranslational regulation for circadian rhythm.
Journal of Biological Chemistry, 1990 A complete cDNA encoding cholesterol 7 alpha-monooxygenase (EC 1.14.13.17) which had been isolated from rat liver cDNA libraries by using specific antibodies to the enzyme (Noshiro, M., Nishimoto, M., and Okuda, K. (1989) FEBS Lett.
M. Noshiro, M. Nishimoto, K. Okuda
semanticscholar +3 more sources
Journal of Lipid Research, 1993 Cholesterol 7 alpha-hydroxylase, the rate-determining enzyme in the bile acid biosynthesis pathway, is regulated in a negative feedback manner by hydrophobic bile salts returning to the liver via the portal circulation.
MP Jones +5 more
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Developmental expression of elements of hepatic cholesterol metabolism in the rat. [PDF]
Journal of Lipid Research, 1995 The expression of several key enzymes and receptors of rat hepatic cholesterol metabolism was studied during development. Among major findings were: acyl coenzyme A:cholesterol acyltransferase, the cholesteryl ester hydrolases, cholesterol-7 alpha ...
J L Smith, S R Lear, S K Erickson
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On the saturation of the cholesterol 7 alpha-hydroxylase in human liver microsomes.
Journal of Lipid Research, 1989 The relationships between cholesterol 7 alpha-hydroxylase activity, pool of free microsomal cholesterol, and degree of substrate saturation of the enzyme were studied in untreated (n = 5), cholesterol-fed (n = 4), and cholestyramine-treated (n = 6 ...
K Einarsson, E Reihnér, I Björkhem
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