Results 1 to 10 of about 34,918 (236)
The composition of rat liver microsomes. The structural proteins of rat liver microsomes [PDF]
Biochemical Journal, 1969 1. The structural-protein component of microsomal membranes was isolated by three separate methods. Analysis by polyacrylamide-gel electrophoresis indicated that the microsomal structural component is made up of a heterogeneous group of proteins. These proteins were further characterized by their phospholipid-binding capacity.
K A, Ward, J K, Pollak
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EFFECT OF TRYPSIN ON LIVER MICROSOMES [PDF]
The Journal of Cell Biology, 1963 The effect of trypsin on the morphology of the rat liver microsomal fraction isolated by differential centrifugation has been investigated. The microsomes were incubated at 37°C and centrifuged thereafter under the conditions of their initial isolation.
J, LUST, P, DROCHMANS
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The Journal of Cell Biology, 1956 Rat liver, liver homogenates, and microsome fractions separated therefrom were examined systematically in the electron microscope in sections of OsO4-fixed, methacrylate-embedded tissue and pellets. It was found that most microsomes are morphologically identical with the rough surfaced elements of the endoplasmic reticula of hepatic ...
G. E. Palade, P. Siekevitz
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Morphine Metabolism in Human Skin Microsomes [PDF]
, 2012 For patients with severe skin wounds, topically applied morphine is an option to induce efficient analgesia due to the presence of opioid receptors in the skin.
Heilmann, S. +4 more
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Biotransformation of (−)-Menthone by Human Liver Microsomes [PDF]
Bioscience, Biotechnology, and Biochemistry, 2006 The aim of the current study was to investigate the metabolism of (-)-menthone by liver microsomes of humans. (-)-Menthone (1) was metabolized to (+)-neomenthol (2) (3-reduction) and 7-hydroxymenthone (3) by human liver microsomes. The metabolites formed were analyzed on GC and GC-MS.
MIYAZAWA, Mitsuo, NAKANISHI, Kyousuke
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Microsomal Esterase of Rat Liver
Journal of Biological Chemistry, 1969 Abstract Rat liver microsomal esterase has been purified 254-fold by a combination of solubilization in a mechanical cell homogenizer, acetone and ammonium sulfate precipitations, and hydroxylapatite column chromatography. The enzyme hydrolyzed glyceryl 1-monodecanoate at a rapid rate; the Km is 1.61 x 10-3 m.
K, Hayase, A L, Tappel
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Debrisoquine metabolism and CYP2D expression in marmoset liver microsomes
, 2011 The objective of this study was to define CYP2D enzymes in marmoset (Callithrix jacchus) liver microsomes, both at the activity level using debrisoquine as the model substrate and at the protein level using antibodies raised to human CYP2D6.
Costas Ioannides +14 more
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Characterisation of androstenone metabolism in pig liver microsomes
, 2004 Androstenone (5α-androst-16-en-3-one) is a steroid pheromone produced in the testis. Excessive accumulation of androstenone together with skatole (3-methyl-indole) in the adipose tissue of some male pigs leads to "boar taint". In isolated pig hepatocytes
Doran (nee Udovikova), Olena +3 more
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Biotransformation of (−)-Verbenone by Human Liver Microsomes
Bioscience, Biotechnology, and Biochemistry, 2002 The biotransformation of (-)-verbenone was investigated with human liver microsomes by using GC-MS. Regioselective biotransformation was observed when (-)-verbenone was incubated with the liver microsomes. (-)-10-Hydroxyverbenone was formed from (-)-verbenone of kinetic analysis showed that the Km and Vmax values for the hydroxylation of (-)-verbenone ...
MIYAZAWA, Mitsuo +2 more
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, 2009 Tanshinone IIa, the primary active component of a traditional Chinese medicine Salvia miltiorrhiza (Danshen), has a wide range of pharmacological activities.
Hu, Y. +6 more
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