Results 1 to 10 of about 28,121 (229)
Development of an LC-MS/MS method to quantitatively analyze escitalopram and its metabolites with application in liver and placenta microsome metabolism [PDF]
Frontiers in PharmacologyBackgroundEscitalopram (SCT), a highly effective and low-risk antidepressant, is widely used in the clinical treatment of depression. It undergoes two N-demethylation steps, producing its primary metabolites, S-demethylcitalopram (S-DCT) and S ...
Yifei Shen +7 more
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Foods, 2021 Nontargeted analysis can be used for the rapid screening and confirmatory analysis of veterinary drugs and their metabolites, which are important for the comprehensive safety evaluation of animal-derived foods.
Bo Wang +5 more
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The Journal of Cell Biology, 1956 Rat liver, liver homogenates, and microsome fractions separated therefrom were examined systematically in the electron microscope in sections of OsO4-fixed, methacrylate-embedded tissue and pellets. It was found that most microsomes are morphologically identical with the rough surfaced elements of the endoplasmic reticula of hepatic ...
G. E. Palade, P. Siekevitz
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The composition of rat liver microsomes. The structural proteins of rat liver microsomes [PDF]
Biochemical Journal, 1969 1. The structural-protein component of microsomal membranes was isolated by three separate methods. Analysis by polyacrylamide-gel electrophoresis indicated that the microsomal structural component is made up of a heterogeneous group of proteins. These proteins were further characterized by their phospholipid-binding capacity.
K A, Ward, J K, Pollak
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EFFECT OF TRYPSIN ON LIVER MICROSOMES [PDF]
The Journal of Cell Biology, 1963 The effect of trypsin on the morphology of the rat liver microsomal fraction isolated by differential centrifugation has been investigated. The microsomes were incubated at 37°C and centrifuged thereafter under the conditions of their initial isolation.
J, LUST, P, DROCHMANS
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Pharmaceutics, 2021 Eudesmin, fargesin, epimagnolin A, magnolin, and yangambin are tetrahydrofurofuranoid lignans with various pharmacological activities found in Magnoliae Flos.
Ria Park +6 more
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Metabolism studies of paeoniflorin in rat liver microsomes by ultra-performance liquid chromatography coupled with hybrid quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS/MS) [PDF]
Royal Society Open Science, 2018 To explore metabolism mechanism of paeoniflorin in the liver and further understand intact metabolism process of paeoniflorin, a rapid, convenient and effective assay is described using ultra-performance liquid chromatography coupled with hybrid ...
L. J. Zhu +3 more
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Pharmacology Research & Perspectives, 2020 Ataluren promotes ribosomal readthrough of premature termination codons in mRNA which result from nonsense mutations. In vitro studies were performed to characterize the metabolism and enzyme kinetics of ataluren and its interaction potential with CYP ...
Ronald Kong +9 more
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Journal of Lipid Research, 1984 3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the enzyme catalyzing the rate-limiting step in cholesterol biosynthesis, exists in one active (dephosphorylated) and one inactive (phosphorylated) form in liver microsomes obtained from several ...
B Angelin +4 more
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The effect of ritonavir on the pharmacokinetics of clonidine
Pakistan Journal of Pharmaceutical Sciences, 2023 This project aims to explore the repercussions of ritonavir on both the drug kinetics of clonidine in rats and clonidine metabolism in liver microsomes.
in vivo +4 more
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