Results 1 to 10 of about 96,126 (327)

Beyond-Rule-of-Five Compounds Are Not Different: In Vitro–In Vivo Extrapolation of Female CD-1 Mouse Clearance Based on Merck Healthcare KGaA Compound Set

Pharmaceuticals
Background: Extrapolation of intrinsic clearance from in vitro systems such as liver microsomes or hepatocytes is an established approach to predict clearance in preclinical species and in humans.
Christine K. Maurer, Zhizhou Fang, Heide M. Duevel, Stephanie Harlfinger, Carl Petersson   +4 more
doaj   +1 more source

Activation of HMG-CoA reductase by microsomal phosphatase

Journal of Lipid Research, 1983
HMG-CoA reductase activity can be modulated by a reversible phosphorylation-dephosphorylation with the phosphorylated form of the enzyme being inactive and the dephosphorylated form, active. Phosphatases from diverse sources, including cytosol, have been
K R Feingold, M H Wiley, A H Moser, S R Lear, M D Siperstein   +4 more
doaj   +1 more source

Über den Steringehalt pflanzlicher Mikrosomen

CHIMIA, 1975
The composition of microsomal lipids from Spirodela oligorrhiza L., Lactuca sativa L., and Allium porrum L. plants was investigated. Contamination by chloroplast lipids was calculated and eliminated, giving the lipids of “chloroplast-free microsomes ...
W. Eichenberger
doaj   +1 more source

Biochemical research elucidating metabolic pathways in Pneumocystis*

Parasite, 2010
Advances in sequencing the Pneumocystis carinii genome have helped identify potential metabolic pathways operative in the organism. Also, data from characterizing the biochemical and physiological nature of these organisms now allow elucidation of ...
Kaneshiro E.S.
doaj   +1 more source

3-hydroxy-3-methylglutaryl coenzyme A reductase in human liver microsomes: active and inactive forms and cross-reactivity with antibody against rat liver enzyme.

Journal of Lipid Research, 1984
3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the enzyme catalyzing the rate-limiting step in cholesterol biosynthesis, exists in one active (dephosphorylated) and one inactive (phosphorylated) form in liver microsomes obtained from several ...
B Angelin, K Einarsson, L Liljeqvist, K Nilsell, RA Heller   +4 more
doaj   +1 more source

Pyridine nucleotide regulation of hepatic endoplasmic reticulum calcium uptake

Physiological Reports, 2019
Pyridine nucleotides serve an array of intracellular metabolic functions such as, to name a few, shuttling electrons in enzymatic reactions, safeguarding the redox state against reactive oxygen species, cytochrome P450 (CYP) enzyme detoxification ...
Xudong Wang, Gail Mick, Kenneth McCormick   +2 more
doaj   +1 more source

Fate of linoleic, arachidonic, and docosa-7,10,13,16-tetraenoic acids in rat testicles

Journal of Lipid Research, 1973
A comparative study was made on the fate of linoleic, arachidonic, and docosa-7,10,13,16-tetraenoic acids in various subcellular fractions of liver and testis from rats of different ages.
Sixta Ayala, Graciela Gaspar, Rodolfo R. Brenner, Raúl O. Peluffo, Wolf Kunau   +4 more
doaj   +1 more source

Inhibition of rat microsomal lipid peroxidation by the oral administration of D002

Brazilian Journal of Medical and Biological Research, 2000
The effect of D002, a defined mixture of higher primary alcohols purified from bee wax, on in vivo and in vitro lipid peroxidation was studied. The extent of lipid peroxidation was measured on the basis of the levels of thiobarbituric acid reactive ...
Menéndez R., Amor A.M., González R.M., Jiménez S., Más R.   +4 more
doaj  

Microsomal Enzyme Induction [PDF]

Toxicological Sciences, 2000
openaire   +2 more sources

Dietary allicin supplementation inhibits hepatic CYP3A37 in chickens: Evidence from in vitro and in vivo models. [PDF]

Poult Sci
Li Y, Yuan H, Wang J, Yin S, Qiu X, Yang H.   +5 more
europepmc   +1 more source