Results 1 to 10 of about 56,066 (278)

In Vivo Metabolite Formation and In Vitro Cytochrome P450-Mediated Metabolism of Vonoprazan in Horses [PDF]

Metabolites
Background/Objectives: Vonoprazan is a potassium-competitive acid blocker with potential for the treatment of equine gastric ulcer syndrome. Vonoprazan metabolic pathways in horses have not been characterized.
Camilo J. Morales, Daniel S. Mckemie, Jayanti Bhandari Neupane, Heather K. Knych   +3 more
doaj   +2 more sources

Contribution of Mass Spectrometry to the Advances in Risk Characterization of Marine Biotoxins: Towards the Characterization of Metabolites Implied in Human Intoxications

Toxins, 2023
A significant spread and prevalence of algal toxins and, in particular, marine biotoxins have been observed worldwide over the last decades. Marine biotoxins are natural contaminants produced during harmful algal blooms being accumulated in seafood, thus
Pablo Estevez, Ana Gago-Martinez
doaj   +1 more source

Structural Features Governing the Metabolic Stability of Tetraethyl-Substituted Nitroxides in Rat Liver Microsomes

Antioxidants, 2023
Nitroxides are potent tools for studying biological systems by electron paramagnetic resonance (EPR). Whatever the application, a certain stability is necessary for successful detection.
Aleksandra Rančić, Nikola Babić, Maylis Orio, Fabienne Peyrot   +3 more
doaj   +1 more source

HPLC with Fluorescence and Photodiode Array Detection for Quantifying Capmatinib in Biological Samples: Application to In Vivo and In Vitro Studies

Molecules, 2022
Capmatinib, a recently approved tyrosine kinase inhibitor, is used for the treatment of non-small cell lung cancer. We describe two new HPLC methods for capmatinib quantification in vivo and in vitro. HPLC with a fluorescence detection method was used to
Aref Zayed, Sana’a A. Jaber, Jomana Al Hroot, Sahar Hawamdeh, Nehad M. Ayoub, Nidal A. Qinna   +5 more
doaj   +1 more source

Δ6- and Δ5-desaturase activities in the human fetal liver: kinetic aspects

Journal of Lipid Research, 1998
Δ6- and Δ5-desaturase activities were studied in human fetal liver microsomes obtained after legally approved therapeutic abortion. Enzyme activities were measured by a radiochemical method using reverse-phase high performance liquid chromatography (HPLC)
Annie Rodriguez, Pierre Sarda, Catherine Nessmann, Pierre Boulot, Claude Louis Leger, Bernard Descomps   +5 more
doaj   +1 more source

Aberrant pathways in the late stages of cholesterol biosynthesis in the rat: origin and metabolic fate of unsaturated sterols relevant to the Smith-Lemli-Opitz syndrome

Journal of Lipid Research, 2000
Minor aberrant pathways of cholesterol biosynthesis normally produce only trace levels of abnormal sterol metabolites but may assume major importance when an essential biosynthetic step is blocked.
Benfang Ruan, James Tsai, William K. Wilson, George J. Schroepfer, Jr.   +3 more
doaj   +1 more source

Quantitative Determination of 5-Aminoisoquinoline, a PARP-1 Inhibitor by UPLC-MS/MS: In Silico ADME Profile and In Vitro Metabolic Stability Study

Applied Sciences, 2022
5-Aminoisoquinoline (5-AIQ) is a water-soluble, potent and selective Poly (ADP-ribose) polymerase 1 (PARP-1) inhibitor, widely used as a biochemical and pharmacological tool to study the inhibitory effect of PARPs enzyme.
Muzaffar Iqbal, Essam A. Ali, Mohd Abul Kalam, Sheikh F. Ahmad, Rashad Al-Salahi   +4 more
doaj   +1 more source

Elucidation of Arctigenin Pharmacokinetics and Tissue Distribution after Intravenous, Oral, Hypodermic and Sublingual Administration in Rats and Beagle Dogs: Integration of In Vitro and In Vivo Findings

Frontiers in Pharmacology, 2017
Although arctigenin (AG) has diverse bioactivities, such as anti-oxidant, anti-inflammatory, anti-cancer, immunoregulatory and neuroprotective activities, its pharmacokinetics have not been systematically evaluated.
Jie Li, Jie Li, Jie Li, Xin Li, Xin Li, Xin Li, Yu-Shan Ren, Yu-Shan Ren, Yuan-Yuan Lv, Yuan-Yuan Lv, Yuan-Yuan Lv, Jun-Sheng Zhang, Jun-Sheng Zhang, Jun-Sheng Zhang, Xiao-Li Xu, Xiao-Li Xu, Xiao-Li Xu, Xian-Zhen Wang, Xian-Zhen Wang, Xian-Zhen Wang, Jing-Chun Yao, Jing-Chun Yao, Jing-Chun Yao, Gui-Min Zhang, Gui-Min Zhang, Zhong Liu, Zhong Liu   +26 more
doaj   +1 more source

Effects of free fatty acids on the enzymic synthesis of diacyl and ether types of choline and ethanolamine phosphoglycerides

Journal of Lipid Research, 1976
Activities of ethanolaminephosphotransferases (EC 2.7.8.1) and choline phosphotransferases (EC 2.7.8.2) in microsomal fractions from brains and livers of mature rats are increased several fold by the addition of 1,2-diacyl-sn-glycerols or 1-alkyl-2-acyl ...
A Radominska-Pyrek, J Strosznajder, Z Dabrowiecki, T Chojnacki, L A Horrocks   +4 more
doaj   +1 more source

Oxidative desaturation of eicosa-8,11-dienoic acid to eicosa-5,8,11-trienoic acid: comparison of different diets on oxidative desaturation at the 5,6 and 6,7 positions

Journal of Lipid Research, 1972
The oxidative desaturation of [1-14C]eicosa-8,11-dienoic acid to eicosa-5,8,11-trienoic acid by rat liver microsomes was studied, and the kinetic conditions appropriate to measure the specific activity of the enzyme were determined.
Juan C. Castuma, Angel Catala, Rodolfo R. Brenner   +2 more
doaj   +1 more source