Qualification of Human Liver Microsomes for Antibacterial Activity Screening of Drug Metabolites [PDF]
Applied Microbiology, 2023 Microsomes are commonly used to perform in vitro drug metabolism, predominantly to form phase I drug metabolites. Pooled microsomes from multiple donors can contain microorganisms from underlying microbial diseases.
Navid Jubaer
doaj +2 more sources
Debrisoquine metabolism and CYP2D expression in marmoset liver microsomes [PDF]
, 2011 The objective of this study was to define CYP2D enzymes in marmoset (Callithrix jacchus) liver microsomes, both at the activity level using debrisoquine as the model substrate and at the protein level using antibodies raised to human CYP2D6.
Costas Ioannides +14 more
core +3 more sources
Morphine Metabolism in Human Skin Microsomes [PDF]
, 2012 For patients with severe skin wounds, topically applied morphine is an option to induce efficient analgesia due to the presence of opioid receptors in the skin.
Heilmann, S. +4 more
core +1 more source
Characterisation of androstenone metabolism in pig liver microsomes [PDF]
, 2004 Androstenone (5α-androst-16-en-3-one) is a steroid pheromone produced in the testis. Excessive accumulation of androstenone together with skatole (3-methyl-indole) in the adipose tissue of some male pigs leads to "boar taint". In isolated pig hepatocytes
Doran (nee Udovikova), Olena +3 more
core +1 more source
BENZO (α) PYRENE METABOLISM BY MICROSOMES AND ISOLATED EPITHELIAL CELLS FROM RAT SMALL INTESTINE [PDF]
, 1977 This chapter discusses benzo(α)pyrene metabolism by microsomes and isolated epithelial cells from rat small intestine. The chapter describes an experiment in which male Sprague–Dawley rats were used. The animals were allowed free access to food and water,
M. Danny Burke +9 more
core +1 more source
Hydroxylation of tanshinone IIa in human liver microsomes is specifically catalysed by cytochrome P4502A6 [PDF]
, 2009 Tanshinone IIa, the primary active component of a traditional Chinese medicine Salvia miltiorrhiza (Danshen), has a wide range of pharmacological activities.
Hu, Y. +6 more
core +1 more source
Stereoselective biotransformation of ketamine in equine liver and lung microsomes [PDF]
, 2008 Stereoselectivity has to be considered for pharmacodynamic and pharmacokinetic features of ketamine. Stereoselective biotransformation of ketamine was investigated in equine microsomes in vitro. Concentration curves were constructed over time, and enzyme
Theurillat, R +9 more
core +1 more source
CYP1A2 is the major isoform responsible for paeonol O-demethylation in human liver microsomes [PDF]
, 2009 1. Paeonol, the primary active component of a traditional Chinese medicine Moutan Cortex, has a wide range of pharmacological activities. In the present study, the metabolism of paeonol by cytochrome P450s (CYPs) was investigated in human liver ...
Hu, Y. +6 more
core +1 more source
Journal of Lipid Research, 1971 Isolated mitochondria cannot synthesize their own phospholipids, there is only an exchange between exogenous and mitochondrial phospholipid fatty acids.
MARIE-THÉRÈSE SAUNER, MARIANNE LÉVY
doaj +1 more source
Relationship between NAFLD and coronary artery disease: A Mendelian randomization study
Hepatology, EarlyView., 2022 Abstract Background and Aims There is an ongoing debate on whether NAFLD is an active contributor or an innocent bystander in the pathogenesis of coronary artery disease (CAD). The aim of the present study was to assess the causal relationship between NAFLD and CAD.
Zhewen Ren +4 more
wiley +1 more source