Results 11 to 20 of about 96,126 (327)

Development of an LC-MS/MS method to quantitatively analyze escitalopram and its metabolites with application in liver and placenta microsome metabolism. [PDF]

Front Pharmacol
BackgroundEscitalopram (SCT), a highly effective and low-risk antidepressant, is widely used in the clinical treatment of depression. It undergoes two N-demethylation steps, producing its primary metabolites, S-demethylcitalopram (S-DCT) and S ...
Shen Y, Yao B, Guo Y, Yang Y, Liang C, Huang J, Zhang Y, Wang X.   +7 more
europepmc   +2 more sources

Structural Features Governing the Metabolic Stability of Tetraethyl-Substituted Nitroxides in Rat Liver Microsomes

Antioxidants, 2023
Nitroxides are potent tools for studying biological systems by electron paramagnetic resonance (EPR). Whatever the application, a certain stability is necessary for successful detection.
Aleksandra Rančić, Nikola Babić, Maylis Orio, Fabienne Peyrot   +3 more
doaj   +1 more source

HPLC with Fluorescence and Photodiode Array Detection for Quantifying Capmatinib in Biological Samples: Application to In Vivo and In Vitro Studies

Molecules, 2022
Capmatinib, a recently approved tyrosine kinase inhibitor, is used for the treatment of non-small cell lung cancer. We describe two new HPLC methods for capmatinib quantification in vivo and in vitro. HPLC with a fluorescence detection method was used to
Aref Zayed, Sana’a A. Jaber, Jomana Al Hroot, Sahar Hawamdeh, Nehad M. Ayoub, Nidal A. Qinna   +5 more
doaj   +1 more source

Metabolism and Metabolic Inhibition of Xanthotoxol in Human Liver Microsomes [PDF]

, 2016
Cytochrome p450 (CYP450) enzymes are predominantly involved in Phase I metabolism of xenobiotics. In this study, the CYP450 isoforms involved in xanthotoxol metabolism were identified using recombinant CYP450s.
Cai, Jiqun, Guo, Feng, Ma, Zhongnv, Shan, Lina, Shi, Xianbao, Zhang, Gang   +5 more
core   +12 more sources

Contribution of Mass Spectrometry to the Advances in Risk Characterization of Marine Biotoxins: Towards the Characterization of Metabolites Implied in Human Intoxications

Toxins, 2023
A significant spread and prevalence of algal toxins and, in particular, marine biotoxins have been observed worldwide over the last decades. Marine biotoxins are natural contaminants produced during harmful algal blooms being accumulated in seafood, thus
Pablo Estevez, Ana Gago-Martinez
doaj   +1 more source

Cytochrome P450 CYP1B1 interacts with 8-methoxypsoralen (8-MOP) and influences psoralen-Ultraviolet A (PUVA) sensitivity [PDF]

, 2013
Background: There are unpredictable inter-individual differences in sensitivity to psoralen-UVA (PUVA) photochemotherapy, used to treat skin diseases including psoriasis.
Deeni, Yusuf Y., Ibbotson, Sally H., Smith, Gillian, Wolf, C. Roland, Woods, Julie A.   +4 more
core   +8 more sources

Quantitative Determination of 5-Aminoisoquinoline, a PARP-1 Inhibitor by UPLC-MS/MS: In Silico ADME Profile and In Vitro Metabolic Stability Study

Applied Sciences, 2022
5-Aminoisoquinoline (5-AIQ) is a water-soluble, potent and selective Poly (ADP-ribose) polymerase 1 (PARP-1) inhibitor, widely used as a biochemical and pharmacological tool to study the inhibitory effect of PARPs enzyme.
Muzaffar Iqbal, Essam A. Ali, Mohd Abul Kalam, Sheikh F. Ahmad, Rashad Al-Salahi   +4 more
doaj   +1 more source

Microsomes, Microsomal Phospholipids, and Fatty Acid Synthesis

Journal of Biological Chemistry, 1969
Abstract The effect of microsomes on fatty acid synthesis by the soluble fraction of rat liver cells has been studied. It was shown that the microsomes contain a heat-labile inhibitory factor, presumably ATPase, and a heat-stable stimulatory factor.
D W, Foster, W P, McWhorter
openaire   +2 more sources

Human CYP4F3s are the main catalysts in the oxidation of fatty acid epoxides

Journal of Lipid Research, 2004
CYP4F isoforms are involved in the oxidation of important cellular mediators such as leukotriene B4 (LTB4) and prostaglandins. The proinflammatory agent LTB4 and cytotoxic leukotoxins have been associated with several inflammatory diseases.
Valérie Le Quéré, Emmanuelle Plée-Gautier, Philippe Potin, Stéphanie Madec, Jean-Pierre Salaün   +4 more
doaj   +1 more source

Oxidative decarboxylation of retinoic acid in microsomes of rat liver and kidney

Journal of Lipid Research, 1968
Liver and kidney microsomes have been found to catalyze a rapid decarboxylation of retinoic acid in vitro. The reaction requires NADPH and Fe2+, and is further stimulated by the presence of pyrophosphate.
Anita B. Roberts, Hector F. DeLuca
doaj   +1 more source