Preparation of ER microsomes from Arabidopsis thaliana [PDF]
Microsomes are vesicles derived from the endoplasmic reticulum (ER) when cells are broken down in the lab. These microsomes are a valuable tool to study a variety of ER functions such as protein and lipid synthesis in vitro.
Kriechbaumer, Verena
core +5 more sources
Morphine Metabolism in Human Skin Microsomes [PDF]
, 2012 For patients with severe skin wounds, topically applied morphine is an option to induce efficient analgesia due to the presence of opioid receptors in the skin.
Heilmann, S. +4 more
core +1 more source
Microsomes, Microsomal Phospholipids, and Fatty Acid Synthesis
Journal of Biological Chemistry, 1969 Abstract The effect of microsomes on fatty acid synthesis by the soluble fraction of rat liver cells has been studied. It was shown that the microsomes contain a heat-labile inhibitory factor, presumably ATPase, and a heat-stable stimulatory factor.
D W, Foster, W P, McWhorter
openaire +2 more sources
Decavanadate displaces inositol 1,4,5-trisphosphate (IP3) from its receptor and inhibits IP3 induced Ca2+ release in permeabilized pancreatic acinar cells [PDF]
, 1991 Inositol 1,4,5-trisphosphate (IP3) induced Ca2+ release in digitonin permeabilized rat pancreatic acinar cells is specifically inhibited by decavanadate.
M. Gratzl +9 more
core +1 more source
The role of the endoplasmic reticulum in the metabolism of "xenobiotica" [PDF]
, 2013 Short-chain dehydrogenase/reductase (SDR) enzymes play a key role in the metabolism of steroids, fatty acids, prostaglandins and xenobiotic chemicals.
Meyer, Arne
core +1 more source
Journal of Lipid Research, 1965 Male rats were divided into three groups and fed a fat-free diet (Group A), a diet supplemented with 7% of ethyl linolenate (Group B), and as a control, a diet supplemented with 7%, of ethyl linoleate (Group C) for 3 weeks.
A. Yamamoto +3 more
doaj +1 more source
NUCLEOSIDE-DIPHOSPHATASE OF CESTODE BOTHRIOCEPHALUS SCORPII (CESTODA: BOTHRIOCEPHALIDAE)
Российский паразитологический журнал, 2016 Objective of research: To study the activities and properties of nucleoside- diphosphatase (NDPase) in cestode Bothriocephalus scorpii.Materials and methods: Cestodes were homogenized with 10 vol. of extraction medium. NDPase was detected in mitochondria
E. A. Burenina
doaj +1 more source
Debrisoquine metabolism and CYP2D expression in marmoset liver microsomes
, 2011 The objective of this study was to define CYP2D enzymes in marmoset (Callithrix jacchus) liver microsomes, both at the activity level using debrisoquine as the model substrate and at the protein level using antibodies raised to human CYP2D6.
Costas Ioannides +14 more
core +2 more sources
Human CYP4F3s are the main catalysts in the oxidation of fatty acid epoxides
Journal of Lipid Research, 2004 CYP4F isoforms are involved in the oxidation of important cellular mediators such as leukotriene B4 (LTB4) and prostaglandins. The proinflammatory agent LTB4 and cytotoxic leukotoxins have been associated with several inflammatory diseases.
Valérie Le Quéré +4 more
doaj +1 more source
Inhibition of in vitro metabolism of testosterone in human, dog and horse liver microsomes to investigate species differences. [PDF]
, 2015 Testosterone hydroxylation was investigated in human, canine and equine liver microsomes and in human and canine single CYPs. The contribution of the CYP families 1, 2 and 3 was studied using chemical inhibitors. Testosterone metabolites were analyzed by
Mevissen, Meike, Zielinski, Jana
core +1 more source