Results 31 to 40 of about 49,246 (285)

Strain‐Release Pentafluorosulfanylation of Carbonyl‐Containing Disubstituted Bicyclobutanes: A Fortuitous Path to SF5‐Containing Oxa[2.1.1]bicyclohexanes

Angewandte Chemie, EarlyView.
A regio‐ and diastereoselective method for strain‐release pentafluorosulfanylation of carbonyl‐containing 1,3‐disubstituted [1.1.0]bicyclobutanes (BCBs) was developed that led to several fortuitous discoveries. For instance, the resultant SF5‐cyclobutanes (SF5‐CBs) exhibit close SF5⋯C═X contacts (X = C, N, O) and provide synthetic access to a new class
Alexander M. Stephens, Jake Anthony Olvera, Yannick Kraemer, Tyson Vu, Wang‐Yeuk Kong, Sudiksha Chaturvedi, Jeffrey M. Wang, Lauren M. Holder, Dean J. Tantillo, Cody Ross Pitts   +9 more
wiley   +2 more sources

Elucidation of Arctigenin Pharmacokinetics and Tissue Distribution after Intravenous, Oral, Hypodermic and Sublingual Administration in Rats and Beagle Dogs: Integration of In Vitro and In Vivo Findings

Frontiers in Pharmacology, 2017
Although arctigenin (AG) has diverse bioactivities, such as anti-oxidant, anti-inflammatory, anti-cancer, immunoregulatory and neuroprotective activities, its pharmacokinetics have not been systematically evaluated.
Jie Li, Jie Li, Jie Li, Xin Li, Xin Li, Xin Li, Yu-Shan Ren, Yu-Shan Ren, Yuan-Yuan Lv, Yuan-Yuan Lv, Yuan-Yuan Lv, Jun-Sheng Zhang, Jun-Sheng Zhang, Jun-Sheng Zhang, Xiao-Li Xu, Xiao-Li Xu, Xiao-Li Xu, Xian-Zhen Wang, Xian-Zhen Wang, Xian-Zhen Wang, Jing-Chun Yao, Jing-Chun Yao, Jing-Chun Yao, Gui-Min Zhang, Gui-Min Zhang, Zhong Liu, Zhong Liu   +26 more
doaj   +1 more source

Effects of free fatty acids on the enzymic synthesis of diacyl and ether types of choline and ethanolamine phosphoglycerides

Journal of Lipid Research, 1976
Activities of ethanolaminephosphotransferases (EC 2.7.8.1) and choline phosphotransferases (EC 2.7.8.2) in microsomal fractions from brains and livers of mature rats are increased several fold by the addition of 1,2-diacyl-sn-glycerols or 1-alkyl-2-acyl ...
A Radominska-Pyrek, J Strosznajder, Z Dabrowiecki, T Chojnacki, L A Horrocks   +4 more
doaj   +1 more source

Intrinsic Clearance in Liver Microsomes. [PDF]

, 2016
Intrinsic Clearance in Liver Microsomes.
William DeMaio (3111543), Ernesto Villanueva (1326108), Jeffrey B. Arterburn (127944), Julius O. Enoru (3111552), Ramesh Chinnasamy (1326099), Ruth G. Perez (1326105), Sesha Krishnamachari (1326114), Adiba Watanyar (3111549), Barbara Yang (3111546)   +8 more
core   +1 more source

Newly Synthesized Creatine Derivatives as Potential Neuroprotective and Antioxidant Agents on In Vitro Models of Parkinson’s Disease

Life, 2023
Oxidative stress is one of the key factors responsible for many diseases–neurodegenerative (Parkinson and Alzheimer) diseases, diabetes, atherosclerosis, etc.
Ivanka Kostadinova, Magdalena Kondeva-Burdina, Lyubomir Marinov, Lubomir L. Vezenkov, Rumyana Simeonova   +4 more
doaj   +1 more source

Oxidative desaturation of eicosa-8,11-dienoic acid to eicosa-5,8,11-trienoic acid: comparison of different diets on oxidative desaturation at the 5,6 and 6,7 positions

Journal of Lipid Research, 1972
The oxidative desaturation of [1-14C]eicosa-8,11-dienoic acid to eicosa-5,8,11-trienoic acid by rat liver microsomes was studied, and the kinetic conditions appropriate to measure the specific activity of the enzyme were determined.
Juan C. Castuma, Angel Catala, Rodolfo R. Brenner   +2 more
doaj   +1 more source

Evaluation of Liver Microsomes for Genotoxicity Sensors—Voltammetry of the Microsomes [PDF]

The Electrochemical Society Interface, 2007
The 2007 Joseph W.
Sadagopan Krishnan, James F. Rusling
openaire   +1 more source

Influence of dietary fatty acids on phospholipid fatty acid composition in subcellular particles of rat liver

Journal of Lipid Research, 1965
Male rats were divided into three groups and fed a fat-free diet (Group A), a diet supplemented with 7% of ethyl linolenate (Group B), and as a control, a diet supplemented with 7%, of ethyl linoleate (Group C) for 3 weeks.
A. Yamamoto, M. Isozaki, K. Hirayama, Y. Sakai   +3 more
doaj   +1 more source

Analyses of CYP2C in Porcine Microsomes [PDF]

Basic & Clinical Pharmacology & Toxicology, 2008
Abstract: The cytochrome P450 2C (CYP2C) subfamily in human beings includes four different isoenzymes that metabolize different substrates although with some cross reactivity. Some of these substrates (e.g. diclofenac and tolbutamide), have been investigated in porcine microsomes, but without identifying the specific CYP catalysing the reactions.
Skaanild, Mette Tingleff, Friis, Christian   +1 more
openaire   +4 more sources

Fumonisin B1 metabolism by bovine liver microsomes [PDF]

, 2001
Only limited and contrasting information is available about the metabolic fate in cattle of fumonisin B1, a mycotoxin produced by moulds of Fusarium. This study was carried out to evaluate the hepatic metabolism of fumonisin B1 by bovine liver microsomes.
F. CALONI, M. SPOTTI, G. POMPA
core   +1 more source