Results 51 to 60 of about 49,138 (216)

Intrinsic Clearance in Liver Microsomes.

, 2016
Intrinsic Clearance in Liver Microsomes.
William DeMaio (3111543), Ernesto Villanueva (1326108), Jeffrey B. Arterburn (127944), Julius O. Enoru (3111552), Ramesh Chinnasamy (1326099), Ruth G. Perez (1326105), Sesha Krishnamachari (1326114), Adiba Watanyar (3111549), Barbara Yang (3111546)   +8 more
core   +1 more source

Revisiting the Latency of Uridine Diphosphate-Glucuronosyltransferases (UGTs)—How Does the Endoplasmic Reticulum Membrane Influence Their Function?

Pharmaceutics, 2017
Uridine diphosphate-glucuronosyltransferases (UGTs) are phase 2 conjugation enzymes mainly located in the endoplasmic reticulum (ER) of the liver and many other tissues, and can be recovered in artificial ER membrane preparations (microsomes).
Yuejian Liu, Michael W. H. Coughtrie
doaj   +1 more source

Synthesis, Screening and Pharmacokinetic Evaluation of Potential Prodrugs of Bupropion. Part One: In Vitro Development

Pharmaceuticals, 2014
In general, prodrugs are developed to circumvent deficiencies associated with the absorption, distribution, metabolism, excretion or toxicological (ADMET) profile associated with the active drug.
Paul Matthew O'Byrne, Robert Williams, John J. Walsh, John F. Gilmer   +3 more
doaj   +1 more source

Identification of Three New N-Demethylated and O-Demethyled Bisbenzylisoquinoline Alkaloid Metabolites of Isoliensinine from Dog Hepatic Microsomes

Molecules, 2012
Isoliensinine, a natural phenolic bisbenzyltetrahydroisoquinoline alkaloid, has received considerable attention for its potential biological effects such as antioxidant and anti-HIV activities.
Su Zeng, Huidi Jiang, Liping Li, Hui Zhou   +3 more
doaj   +1 more source

Fumonisin B1 metabolism by bovine liver microsomes

, 2001
Only limited and contrasting information is available about the metabolic fate in cattle of fumonisin B1, a mycotoxin produced by moulds of Fusarium. This study was carried out to evaluate the hepatic metabolism of fumonisin B1 by bovine liver microsomes.
F. CALONI, M. SPOTTI, G. POMPA
core   +1 more source

Changes In the lipid composition of rat hepatic microsomes induced by the diet

Grasas y Aceites, 1994
The effect on the hepatic microsomes from rats fed with either virgin olive oil (10%) or fish oil (10%), with or without added cholesterol (1%), has been studied.
V. Ruíz Gutiérrez, A. Pérez Espinosa, F. J. García Muriana   +2 more
doaj   +1 more source

The composition of rat liver microsomes. The structural proteins of rat liver microsomes [PDF]

Biochemical Journal, 1969
1. The structural-protein component of microsomal membranes was isolated by three separate methods. Analysis by polyacrylamide-gel electrophoresis indicated that the microsomal structural component is made up of a heterogeneous group of proteins. These proteins were further characterized by their phospholipid-binding capacity.
K A, Ward, J K, Pollak
openaire   +2 more sources

Impact of Subacute Exposure to T-2 Toxin and Zearalenone on the Pharmacokinetics of Midazolam as CYP3A Probe Drug in a Porcine Animal Model: A Pilot Study

Frontiers in Pharmacology, 2019
Cytochrome P450 enzymes (CYP) are important catalyzing proteins involved in the biotransformation of endogenous and xenobiotic compounds. However, their expression and/or activity can be altered by exposure to contaminants such as mycotoxins.
Wim Schelstraete, Mathias Devreese, Siska Croubels   +2 more
doaj   +1 more source

In Vitro Glucuronidation of Wushanicaritin by Liver Microsomes, Intestine Microsomes and Expressed Human UDP-Glucuronosyltransferase Enzymes

, 2017
Wushanicaritin, a natural polyphenol compound, exerts many biological activities. This study aimed to characterize wushanicaritin glucuronidation by pooled human liver microsomes (HLM), human intestine microsomes and individual uridine diphosphate ...
Frank Gonzalez, Xiaodan Hong, Zifei Qin, Baojian Wu, Hao Gao, Xinsheng Yao, Yi Dai, Yuanru Zheng, Zhihong Yao   +8 more
core   +1 more source

Proteomic Profiling of the Microsomal Root Fraction: Discrimination of Pisum sativum L. Cultivars and Identification of Putative Root Growth Markers

Proteomes, 2017
Legumes are a large and economically important family, containing a variety of crop plants. Alongside different cereals, some fruits, and tropical roots, a number of leguminosae evolved for millennia as crops with human society.
Claudia-Nicole Meisrimler, Stefanie Wienkoop, Sabine Lüthje   +2 more
doaj   +1 more source