Results 51 to 60 of about 56,066 (278)
Metabolism of palmitic acid in the subcellular fractions of mouse brain
Journal of Lipid Research, 1973 After an intracerebral injection of [14C]palmitic acid to C57BL/10J mice, the radioactivity in the brains decreased rapidly with time. The incorporated radioactivity was primarily in the 16:0 acyl groups of the diacyl phosphoglycerides at 1 and 3 days ...
Grace Y. Sun, Lloyd A. Horrocks
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Advanced Science, EarlyView.A novel geometry‐resolved membrane platform provides a seamlessly integrated pipeline for studying curvature‐sensing proteins. By linking shotgun proteomics with quantitative imaging, this approach enables both the unbiased discovery and rigorous validation of novel sensors across the entire curvature range—positive, negative, and zero.
Takumi Komikawa +6 more
wiley +1 more source
Frontiers in Pharmacology, 2018 Naftopidil (NAF) is widely used for the treatment of benign prostatic hyperplasia and prevention of prostate cancer in elderly men. These patients receive a combination of drugs, which involves high risk for drug–drug interaction.
Xia-Wen Liu +9 more
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Evaluation of herb-drug interaction of ambrisentan with shikonin based on UPLC-MS/MS
Pharmaceutical Biology, 2021 Context Ambrisentan is an oral endothelin-receptor antagonist (ERA). However, there is no report on the interaction between ambrisentan and shikonin.
Tian Lan +4 more
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Characterization of triptolide hydroxylation by cytochrome P450 in human and rat liver microsomes
, 2008 Triptolide, the primary active component of a traditional Chinese medicine Tripterygium wilfordii Hook F, has a wide range of pharmacological activities. In the present study, the metabolism of triptolide by cytochrome P450s was investigated in human and
Liu, H. -T. +13 more
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Advanced Science, EarlyView.Chemical switching of OGG1 by CMM‐98 accelerates oxidative DNA damage repair and enhances hepatocyte resilience during acetaminophen‐induced acute liver injury. By promoting efficient processing of OGG1‐generated repair intermediates, CMM‐98 reduces oxidative damage, preserves cellular integrity, and protects against acute liver failure, identifying ...
Zhenjun Zhao +25 more
wiley +1 more source
Enzymatic synthesis of cytidine diphosphate diglyceride
Journal of Lipid Research, 1966 Evidence is presented for the enzymatic formation of cytidine diphosphate diglyceride in microsomal preparations from guinea pig liver according to the reaction:CTP + phosphatidic acid ⇌ CDP-diglyceride + P—O—P.Conditions have been found in which the ...
James R. Carter, Eugene P. Kennedy
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Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.OxSpred, an eXtreme‐Gradient‐Boosting‐‐based supervised learning model, accurately annotates oxidative stress in innate immune cells at the single‐cell level, providing interpretable embeddings with significant biological relevance. This innovative tool revolutionizes the understanding of innate immune cell functions during inflammation and enhances ...
Po‐Yuan Chen, Tai‐Ming Ko
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Effect of dietary monosodium glutamate on trans fat-induced nonalcoholic fatty liver disease
Journal of Lipid Research, 2009 The effects of dietary monosodium glutamate (MSG) on trans-fatty acid (TFA)-induced nonalcoholic fatty liver disease (NAFLD) are addressed in an animal model.
Kate S. Collison +9 more
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Qualification of Human Liver Microsomes for Antibacterial Activity Screening of Drug Metabolites
Applied Microbiology, 2023 Microsomes are commonly used to perform in vitro drug metabolism, predominantly to form phase I drug metabolites. Pooled microsomes from multiple donors can contain microorganisms from underlying microbial diseases.
Navid Jubaer
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