Results 61 to 70 of about 96,126 (327)

Human UDP-Glucuronosyltransferase 2B4 and 2B7 Are Responsible for Naftopidil Glucuronidation in Vitro

Frontiers in Pharmacology, 2018
Naftopidil (NAF) is widely used for the treatment of benign prostatic hyperplasia and prevention of prostate cancer in elderly men. These patients receive a combination of drugs, which involves high risk for drug–drug interaction.
Xia-Wen Liu, Yi Rong, Xing-Fei Zhang, Jun-Jun Huang, Yi Cai, Bi-Yun Huang, Liu Zhu, Bo Wu, Ning Hou, Cheng-Feng Luo   +9 more
doaj   +1 more source

Evaluation of herb-drug interaction of ambrisentan with shikonin based on UPLC-MS/MS

Pharmaceutical Biology, 2021
Context Ambrisentan is an oral endothelin-receptor antagonist (ERA). However, there is no report on the interaction between ambrisentan and shikonin.
Tian Lan, Ping Fang, Xuemei Ye, Xia Lan, Ren-ai Xu   +4 more
doaj   +1 more source

OXidative Stress PREDictor: A Supervised Learning Approach for Annotating Cellular Oxidative Stress States in Inflammatory Cells

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
OxSpred, an eXtreme‐Gradient‐Boosting‐‐based supervised learning model, accurately annotates oxidative stress in innate immune cells at the single‐cell level, providing interpretable embeddings with significant biological relevance. This innovative tool revolutionizes the understanding of innate immune cell functions during inflammation and enhances ...
Po‐Yuan Chen, Tai‐Ming Ko
wiley   +1 more source

Nanostructures of diamond, graphene oxide and graphite inhibit CYP1A2, CYP2D6 and CYP3A4 enzymes and downregulate their genes in liver cells

International Journal of Nanomedicine, 2018
Barbara Strojny,1 Ewa Sawosz,1 Marta Grodzik,1 Sławomir Jaworski,1 Jarosław Szczepaniak,1 Malwina Sosnowska,1 Mateusz Wierzbicki,1 Marta Kutwin,1 Sylwia Orlińska,1 André Chwalibog2 1Division of Nanobiotechnology, Warsaw University of Life ...
Strojny B, Sawosz E, Grodzik M, Jaworski S, Szczepaniak J, Sosnowska M, Wierzbicki M, Kutwin M, Orlińska S, Chwalibog A   +9 more
doaj  

Enzymatic synthesis of cytidine diphosphate diglyceride

Journal of Lipid Research, 1966
Evidence is presented for the enzymatic formation of cytidine diphosphate diglyceride in microsomal preparations from guinea pig liver according to the reaction:CTP + phosphatidic acid ⇌ CDP-diglyceride + P—O—P.Conditions have been found in which the ...
James R. Carter, Eugene P. Kennedy
doaj   +1 more source

Relative Exchangeable Copper Confirms Wilson Disease and Supports Reclassification of the ATP7B p.Met665Ile Variant With Conflicting Pathogenicity Evidence

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Wilson disease (WD) is an autosomal recessive disorder of copper metabolism caused by ATP7B mutations. Diagnosis is usually straightforward in symptomatic patients, but can be challenging in children and adolescents with mild liver disease, borderline urinary copper excretion, or inconclusive genetic findings.
Emanuele Nicastro, Caterina Zuccoli, Roberto Marozzi, Antonino Barletta, Lisa Licini, Paola Tebaldi, Valeria Casotti, Mariangela Stinco, Lidia Pezzani, Maria Iascone, Lorenzo D'Antiga   +10 more
wiley   +1 more source

Effect of dietary monosodium glutamate on trans fat-induced nonalcoholic fatty liver disease

Journal of Lipid Research, 2009
The effects of dietary monosodium glutamate (MSG) on trans-fatty acid (TFA)-induced nonalcoholic fatty liver disease (NAFLD) are addressed in an animal model.
Kate S. Collison, Zakia Maqbool, Soad M. Saleh, Angela Inglis, Nadine J. Makhoul, Razan Bakheet, Mohammed Al-Johi, Rana Al-Rabiah, Marya Z. Zaidi, Futwan A. Al-Mohanna   +9 more
doaj   +1 more source

Qualification of Human Liver Microsomes for Antibacterial Activity Screening of Drug Metabolites

Applied Microbiology, 2023
Microsomes are commonly used to perform in vitro drug metabolism, predominantly to form phase I drug metabolites. Pooled microsomes from multiple donors can contain microorganisms from underlying microbial diseases.
Navid Jubaer
doaj   +1 more source

Biogenesis of Cytochrome c in Neurospora crassa [PDF]

, 1978
# 1. Precipitating antibodies specific for apocytochrome c and holocytochrome c, respectively, were employed to study synthesis and intracellular transport of cytochrome c in Neurospora in vitro. # 2.
Korb, Harald, Neupert, Walter
core   +1 more source

A Comparative Study of Phase I and II Hepatic Microsomal Biotransformation of Phenol in Three Species of Salmonidae: Hydroquinone, Catechol, and Phenylglucuronide Formation

Fishes
The in vitro biotransformation of phenol at 11 °C was studied using pre-spawn adult rainbow (Oncorhynchus mykiss) (RBT), brook (Salvelinus fontinalis) (BKT), and lake trout (Salvelinus namaycush) (LKT) hepatic microsomal preparations.
Richard C. Kolanczyk, Laura E. Solem, Patricia K. Schmieder, James M. McKim   +3 more
doaj   +1 more source