Results 61 to 70 of about 49,138 (216)

Comparative Metabolism of Cinobufagin in Liver Microsomes from Mouse, Rat, Dog, Minipig, Monkey, and Human

, 2011
Comparative Metabolism of Cinobufagin in Liver Microsomes from Mouse, Rat, Dog, Minipig, Monkey, and HumanCinobufagin (CB), a major bioactive component of the traditional Chinese medicine Chansu, has been reported to have potent antitumor activity.
Ning, Jing, Liang, Si-Cheng, Li, Jing-Kui, 杨凌, Huang, Shan-Shan, Ge, Guang-Bo, Wang, Xiu-Li, Yang, Ling, Ma, Xiao-Chi, Zhang, Bao-Jing   +9 more
core   +1 more source

microsome

, 2014
Citation: 'microsome' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.M03917 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

Biphenyl Hydroxylation by Vole Hepatic Microsomes

, 1981
Metabolism of biphenyl by meadow voles (Microtus montanus) liver microsomes was studied by gas liquid chromatography. The microsomal biphenyl hydroxylation of Swiss Webster mice (outbred) was also investigated to provide a species comparison.
Makary, Moheb H.
core   +1 more source

Polyunsaturated fatty acid accumulation in the lipids of cultured fibroblasts and smooth muscle cells

Journal of Lipid Research, 1981
The lipid content per cell of cells in tissue culture depended on the cell type. Fibroblasts derived from human neonatal foreskin contained less triglyceride and phospholipid and more cholesteryl ester than smooth muscle cells derived from guinea pig ...
V C Gavino, J S Miller, J M Dillman, G E Milo, D G Cornwell   +4 more
doaj   +1 more source

Metabolism of tyrosine kinase inhibitor cabozantinib by rat liver microsomes [PDF]

, 2019
Cabozantinib is an anticancer drug that was approved for treatment of progressive thyroid cancer by FDA and EMA organizations. Cabozantinib is a tyrosine kinase inhibitor. It blocks signal pathway receptors that are important for growth of tumors.
Jurečka, Tomáš
core  

Lipid composition of heart muscle homogenate

Journal of Lipid Research, 1965
Using cytochrome oxidase and esterase assays as a guide, mitochondria and microsomes were prepared from ox heart homogenate with about 25% cross-contamination of phospholipid.
L.W. Wheeldon, Z. Schumert, D.A. Turner
doaj   +1 more source

Beyond-Rule-of-Five Compounds Are Not Different: In Vitro–In Vivo Extrapolation of Female CD-1 Mouse Clearance Based on Merck Healthcare KGaA Compound Set

Pharmaceuticals
Background: Extrapolation of intrinsic clearance from in vitro systems such as liver microsomes or hepatocytes is an established approach to predict clearance in preclinical species and in humans.
Christine K. Maurer, Zhizhou Fang, Heide M. Duevel, Stephanie Harlfinger, Carl Petersson   +4 more
doaj   +1 more source

UGT1A6 and UGT1A9 involving in the metabolism of daphnetin by human liver microsomes

, 2009
Daphnetin (7, 8-dihydroxycoumarin), one of coumarin derivatives, is the major bioactive constituent from Daphne odora (Thymelaeaceae). Previous studies indicated that daphnetin has the anti-coagulant activity like other coumarin analogs, and other ...
梁思成, 葛广波, Yang L, 杨凌, 刘慧鑫   +4 more
core  

Binding of uteroglobin to microsomes and plasmatic membranes

, 1995
Microsomes and plasmatic membranes from rat liver bind radioactive uteroglobin (UG) in vitro with high affinity (Kd = 1.7 × 10−10 M). The binding is saturable and specific and dependent on previous reduction of UG with dithiothreitol. Microsomes from rat
Antonio Nieto, González, Keybell Díaz, Keybell Díaz González, Nieto, Antonio   +3 more
core   +1 more source

Activation of HMG-CoA reductase by microsomal phosphatase

Journal of Lipid Research, 1983
HMG-CoA reductase activity can be modulated by a reversible phosphorylation-dephosphorylation with the phosphorylated form of the enzyme being inactive and the dephosphorylated form, active. Phosphatases from diverse sources, including cytosol, have been
K R Feingold, M H Wiley, A H Moser, S R Lear, M D Siperstein   +4 more
doaj   +1 more source