Results 81 to 90 of about 56,066 (278)
Fumonisin B1 metabolism by bovine liver microsomes
, 2001 Only limited and contrasting information is available about the metabolic fate in cattle of fumonisin B1, a mycotoxin produced by moulds of Fusarium. This study was carried out to evaluate the hepatic metabolism of fumonisin B1 by bovine liver microsomes.
F. CALONI, M. SPOTTI, G. POMPA
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British Journal of Clinical Pharmacology, EarlyView.Abstract Cyclizine is a long‐established, short‐acting drug, registered for preventing motion sickness, post‐operative nausea and vomiting (PONV) and ‘vomiting of known cause’. The latter is not defined but may include pregnancy and patients receiving palliative care, historically accepted without large, controlled trials.
Gareth J. Sanger, Paul L. R. Andrews
wiley +1 more source
Binding of uteroglobin to microsomes and plasmatic membranes [PDF]
, 1995 Microsomes and plasmatic membranes from rat liver bind radioactive uteroglobin (UG) in vitro with high affinity (Kd = 1.7 × 10−10 M). The binding is saturable and specific and dependent on previous reduction of UG with dithiothreitol. Microsomes from rat
Antonio Nieto +3 more
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Bulletin of the Korean Chemical Society, EarlyView.This graphic abstract illustrates the role of the Korea Chemical Bank (KCB) as a central national hub that integrates government R&D, academic compound deposits, and industrial drug discovery throughout the latter half of KRICT's 50‐year history. Abstract Since its establishment in 2000 under the Korea Research Institute of Chemical Technology (KRICT),
Seul‐Gee Hwang +18 more
wiley +1 more source
BMEMat, EarlyView.Nanomedicine‐Driven Strategies for Suppressing Postoperative Tumor Recurrence. This schematic illustrates three pivotal nanomedical strategies that synergistically counteract recurrence by targeting residual disease and the immunosuppressive tumor microenvironment within the surgical cavity.
Lisong Pang +8 more
wiley +1 more source
Journal of Lipid Research, 1981 The lipid content per cell of cells in tissue culture depended on the cell type. Fibroblasts derived from human neonatal foreskin contained less triglyceride and phospholipid and more cholesteryl ester than smooth muscle cells derived from guinea pig ...
V C Gavino +4 more
doaj +1 more source
, 2017 Wushanicaritin, a natural polyphenol compound, exerts many biological activities. This study aimed to characterize wushanicaritin glucuronidation by pooled human liver microsomes (HLM), human intestine microsomes and individual uridine diphosphate ...
Frank Gonzalez +8 more
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Chemistry – A European Journal, EarlyView.Balancing Act: Se─M bond serving as the fulcrum of the balance scale to compare the different weight of toxicity and therapeutic effects in biological environment. ABSTRACT The synthesis and characterization of organo‐selenium compounds have attracted considerable interest for decades, driven by the search for efficient catalysts and bioinspired ...
Matteo Filippi +6 more
wiley +1 more source
Repurposing Drugs for Malaria through a Human Dose Prediction: A Case Study with Berzosertib
Clinical Pharmacology &Therapeutics, EarlyView.Repurposing drugs whose clinical safety has been established offers a valuable approach to reduce the cost and time associated with the development of new drugs for malaria. Here, we investigate the potential to repurpose the anticancer kinase inhibitor berzosertib for the treatment of malaria, by assessing whether a predicted efficacious human dose ...
Devasha Redhi +5 more
wiley +1 more source
Lipid composition of heart muscle homogenate
Journal of Lipid Research, 1965 Using cytochrome oxidase and esterase assays as a guide, mitochondria and microsomes were prepared from ox heart homogenate with about 25% cross-contamination of phospholipid.
L.W. Wheeldon, Z. Schumert, D.A. Turner
doaj +1 more source