Results 31 to 40 of about 63,034 (211)

Cytochrome P450 CYP1B1 interacts with 8-methoxypsoralen (8-MOP) and influences psoralen-Ultraviolet A (PUVA) sensitivity [PDF]

, 2013
Background: There are unpredictable inter-individual differences in sensitivity to psoralen-UVA (PUVA) photochemotherapy, used to treat skin diseases including psoriasis.
Deeni, Yusuf Y., Ibbotson, Sally H., Smith, Gillian, Wolf, C. Roland, Woods, Julie A.   +4 more
core   +4 more sources

Liver microsomal epoxide hydrase.

Journal of Biological Chemistry, 1977
1. The substrate specificity of membrane-bound and purified epoxide hydrase from rat liver microsomes has been studied. Both enzyme preparations catalyzed the hydration of a variety of alkene oxidase as well as arene oxides of several polycyclic aromatic hydrocarbons. 2. Unlike the membrane-bound enzyme, the rate of hydration for most of the substrates
A Y, Lu, D M, Jerina, W, Levin
openaire   +2 more sources

Interspecies Variation in NCMN-O-Demethylation in Liver Microsomes from Various Species

Molecules, 2019
NCMN (N-(3-carboxy propyl)-4-methoxy-1,8-naphthalimide), a newly developed ratiometric two-photon fluorescent probe for human Cytochrome P450 1A (CYP1A), shows the best combination of specificity and reactivity for real-time detection of the enzymatic ...
Ziru Dai, Guibo Sun, Jiada Yang, Jie Hou, Ping Zhou, Weijie Xie, Guangbo Ge, Xiaobo Sun, Ling Yang   +8 more
doaj   +1 more source

The metabolism of gelsevirine in human, pig, goat and rat liver microsomes

Veterinary Medicine and Science, 2021
Gelsemium is a small genus of flowering plants from the family Loganiaceae comprising five species, three of which, Gelsemium sempervirens (L.) J. St.‐Hil., G. elegans Benth and G. rankinii Small, are particularly popular.
Hua‐Hai Zhang, Wen‐Jia Yang, Ya‐Jun Huang, Wen‐Jing Li, Shuo‐Xin Zhang, Zhao‐Ying Liu   +5 more
doaj   +1 more source

UPLC-MS/MS analysis of ochratoxin A metabolites produced by Caco-2 and HepG2 cells in a co-culture system [PDF]

, 2017
Ochatoxin A (OTA) is one of the most important mycotoxins based on its toxicity. The oral route is the main gateway of entry of OTA into the human body, and specialized epithelial cells constitute the first barrier.
González Arias, Cyndia A., Marín Sillué, Sònia, Ramos Girona, Antonio J., Rojas-García, A. E., Sanchís Almenar, Vicente   +4 more
core   +2 more sources

Hydroxymethylglutaryl CoA reductase and the modulation of microsomal cholesterol content by the nonspecific lipid transfer protein.

Journal of Lipid Research, 1984
The influence of membrane cholesterol content on 3-hydroxy-3-methylglutaryl CoA reductase (HMG-CoA reductase, EC 1.1.1.34) in rat liver microsomes was investigated.
G P van Heusden, K W Wirtz
doaj   +1 more source

Effect of blood plasma lipoproteins on hydroxylation of benzo[a]pyrene in liver microsomes of rats

Атеросклероз, 2020
This work presents the characteristics of the catalytic activity of hydroxylation of benzo[a] pyrene (B[a]P) in rat liver microsomes using plasma lipoproteins (LP) (VLDL, LDL, HDL) as transport forms of B[a]P.
L. M. Polyakov, R. A. Knyazev, N. V. Trifonova, M. V. Kotova, E. I. Solovyova, A. V. Ryabchenko   +5 more
doaj   +1 more source

Development of indole sulfonamides as cannabinoid receptor negative allosteric modulators [PDF]

, 2016
This Letter was supported by the Biotechnology and Biological Sciences Research Council (BBSRC) and the Scottish Universities Life Sciences Alliance (SULSA) in 2011Peer ...
Abdelrahman, Mostafa Hamed, Baillie, Gemma L., Greig, Iain R., Ross, Ruth A., Trembleau, Laurent   +4 more
core   +1 more source

Human Liver Microsomal Metabolism of (+)-Discodermolide [PDF]

Journal of Natural Products, 2009
The polyketide natural product (+)-discodermolide is a potent microtubule stabilizer that has generated considerable interest in its synthetic, medicinal, and biological chemistry. It progressed to early clinical oncology trials, where it showed some efficacy in terms of disease stabilization but also some indications of causing pneumotoxicity ...
Yun, Fan, Emanuel M, Schreiber, Billy W, Day   +2 more
openaire   +2 more sources

Scientific Opinion on Flavouring Group Evaluation 302 (FGE.302): N-(2-methylcyclohexyl)-2,3,4,5,6-pentafluoro-benzamide from Chemical Group 30 [PDF]

, 2017
Publisher ...
Anastassiadou, Maria, Bolognesi, Claudia, Brimer, Leon, Castle, Laurence, Cravedi, Jean-Pierre, de Fátima Tavares Poças, Maria, EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF), Engel, Karl-Heinz, Fowler, Paul, Franz, Roland, Grob, Konrad, Gürtler, Rainer, Husøy, Trine, Kärenlampi, Sirpa, Mennes, Wim, Mulder, Gerard, Penninks, André, Rosaria Milana, Maria, Silano, Vittorio, Smith, Andrew, Sundh, Ulla Beckman, Tlustos, Christina, Wölfle , Detlef, Zorn, Holger, Zugravu, Corina-Aurelia   +24 more
core   +3 more sources