Results 51 to 60 of about 2,738,308 (324)

ANALYTICAL STUDY OF MICROSOMES AND ISOLATED SUBCELLULAR MEMBRANES FROM RAT LIVER

Journal of Cell Biology, 1974
The series introduced by this paper reports the results of a detailed analysis of the microsomal fraction from rat liver by density gradient centrifugation.
H. Beaufay, A. Amarcostesec, E. Feytmans, D. Thinès-Sempoux, M. Wibo, M. Robbi, J. Berthet   +6 more
semanticscholar   +1 more source

Hydroxylation of tanshinone IIa in human liver microsomes is specifically catalysed by cytochrome P4502A6

, 2009
Tanshinone IIa, the primary active component of a traditional Chinese medicine Salvia miltiorrhiza (Danshen), has a wide range of pharmacological activities.
Hu, Y., Li, W., 杨凌, He, Y. -Q., Liu, Y., Yang, L., Liu, H. -X.   +6 more
core   +1 more source

The role of the endoplasmic reticulum in the metabolism of "xenobiotica" [PDF]

, 2013
Short-chain dehydrogenase/reductase (SDR) enzymes play a key role in the metabolism of steroids, fatty acids, prostaglandins and xenobiotic chemicals.
Meyer, Arne
core   +1 more source

A comprehensive characterization biotransformation of chlorinated paraffin by human and carp liver microsomes via liquid chromatography-high-resolution mass spectrometry and screening algorithm

Environment International
The chlorinated paraffin (CP) monomer 1,2,5,6,9,10-Hexachlorodecane (CP-4) was subjected to in vitro biotransformation using human and carp liver microsomes.
Liujun Chen, Caiming Tang, Zhiqiang Yu, Yanhong Zeng, Bixian Mai, Xiaojun Luo   +5 more
doaj   +1 more source

Chemical Bond‐Orchestrated Energy Depletion to Augment Lung Cancer Chemo‐Immunotherapy

Advanced Science, EarlyView.
This study grafted dichloroacetic acid (DCA) into perylenediimide (PDI) skeleton via ionic or covalent bond to create novel metabolic agent PDIC‐AC and PDIC‐NAC, explicitly elaborated the underlying energy metabolism and therapeutic mechanism, and developed a promising strategy for energy metabolism‐targeting chemo‐immunotherapy by chemical bond ...
Xuejie Zhao, Yuting Liu, Xiao Huang, Liwen Zhao, Chunli Li, Yongwei Huang   +5 more
wiley   +1 more source

Über den Steringehalt pflanzlicher Mikrosomen

CHIMIA, 1975
The composition of microsomal lipids from Spirodela oligorrhiza L., Lactuca sativa L., and Allium porrum L. plants was investigated. Contamination by chloroplast lipids was calculated and eliminated, giving the lipids of “chloroplast-free microsomes ...
W. Eichenberger
doaj   +1 more source

Characterization of Lysosomal Hydrolases and Transporters and Their Age-Dependent Variability: Relevance to Drug Metabolism and Transport of Small Molecule and Biologic Drugs. [PDF]

Clin Pharmacol Ther
Lysosomes play a key role in the accumulation, catabolism, and transport of endogenous and exogenous metabolites and proteins and are involved in drug metabolism and prodrug activation. However, the protein abundance and interindividual variability of lysosomal drug‐metabolizing enzymes and transporters (DMETs) remain underexplored.
Gadara D, Singh DK, Subash S, Yue G, Ahire D, Bohl C, Czerwinski M, Helmstetter S, Heyward S, Jones RS, Khojasteh C, Kikuchi R, Kulkarni P, Ma B, Murray B, Seib C, Smith B, Stresser DM, Taub ME, Wang T, Prasad B.   +20 more
europepmc   +2 more sources

Drug-related problems and dosage adjustment in patients with liver disease [PDF]

, 2012
The liver is essential for the metabolism of medicinal substances. Liver disease, especially liver cirrhosis, may lead to various pharmacokinetic and pharmacodynamic changes, predisposing patients with liver cirrhosis to adverse drug events (ADEs).
Franz, Carmen Carina
core   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

CYP1A2 is the major isoform responsible for paeonol O-demethylation in human liver microsomes

, 2009
1. Paeonol, the primary active component of a traditional Chinese medicine Moutan Cortex, has a wide range of pharmacological activities. In the present study, the metabolism of paeonol by cytochrome P450s (CYPs) was investigated in human liver ...
Hu, Y., Li, W., 杨凌, He, Y. -Q., Liu, Y., Yang, L., Liu, H. -X.   +6 more
core   +1 more source