Results 51 to 60 of about 34,918 (236)
A new pathway for phosphatidylserine synthesis in rat liver microsomes
, 1988 It has been shown that the phosphate moiety of glycerophosphate is incorporated into phosphatidylserine of rat liver microsomes, but not of mitochondria. The reaction is dependent on CMP.
Baraǹska, Jolanta, Jolanta Baraǹska
core +1 more source
, 2011 Cytochrome P450 (CYP) enzymes are widely studied for their involvement in metabolism of drugs and endogenous compounds. In porcine liver, CYP1A2,2Aand 2E1 are important for the metabolism of skatole.Feeding chicory roots to pigs is known to decrease the ...
Martin Krøyer Rasmussen +5 more
core +1 more source
Genetic variants of flavin-containing monooxygenases: consequences for drug metabolism
, 2010 The metabolism of the anti-tubercular drug, thiacetazone (TAZ) by human FMOs in vitro and the disposition of TAZ in vivo in mice were studied. Reverse phase chromatography confirmed TAZ to be a substrate for human FMO1, FMO2.1 and FMO3 with the ...
Francois, A.
core
Journal of Clinical Laboratory Analysis, EarlyView.The assay exploited a multiparametric and fully automated device applied to CHORUS EVO to validate that the CHORUS Macroarray Liver Diseases kit is a novel procedure for detecting autoantibodies of AIH and PBC. The assay resulted as linear, accurate, sensitive, specific, and able to distinguish between PBC and AIH.
Luigi Raganelli +14 more
wiley +1 more source
Characterization of in vitro bioactivation of rutaecarpine in human liver microsomes (HLMs)
, 2010 Reactive drug metabolites have been always considered mediators of drug-induced toxicities and risk would increase with the increasing reactive metabolites.
房中则, Ling Yang, 杨凌
core
, 2017 Use of the immunosuppressant mycophenolic acid (MPA) in cats is limited because MPA elimination depends on glucuronidation, which is deficient in cats.
Slovak, J E, Mealey, K, Court, M H
core +1 more source
JPGN Reports, EarlyView.Abstract Wilson disease (WD) is an autosomal recessive disorder of hepatic copper metabolism with varied clinical presentations. We describe a 15‐year‐old male referred for elevated aminotransferases, burning facial pruritis, scalp dysesthesias, and chronic bilateral lower extremity edema.
Tierra L. R. Mosher +2 more
wiley +1 more source
Metabolic Difference of CZ48 in Human and Mouse Liver Microsomes
, 2012 CZ48, chemically camptothecin-20-O-propionate hydrate, is currently under clinical investigation. The kinetics of the metabolite camptothecin (CPT) formation and of CZ48 depletion in mouse and human liver microsomes in the presence or absence of NADPH ...
Xing Liu +4 more
core +1 more source
Codeine and Metabolite Concentrations in the Breastfed Neonate
Pediatric Anesthesia, EarlyView.ABSTRACT Analgesic effect from codeine is from its metabolite, morphine. Morphine is formed by the O‐demethylation of codeine and that enzyme is controlled by the cytochrome P450 2D6. More than 60 alleles in the CYP2D6 gene have been identified. This spectrum of polymorphism can be categorized into four groups: poor (PM), intermediate (IM), normal (NM),
Brian J. Anderson, Jacqueline A. Hannam
wiley +1 more source
, 2010 Cinobufagin (CBG), a major bioactive component of Traditional Chinese Medicine ChanSu with digoxin-like structure, has been reported with Na+-K+-ATPase inhibitory effects and outstanding antitumor activities.
梁思成 +4 more
core