Results 71 to 80 of about 34,918 (236)
, 1979 The effects of naturally occurring microsomal enzyme inducers on important hepatocellular pathways for the metabolism of foreign compounds (xenobiotics) and also upon the incidence of liver tumours in CF-1 mice treated or not with 10 mg dieldrin.kg ...
Tennekes, H.A.
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, 1988 The capacity of human, rabbit and rat liver microsomes and purified isozymes of cytochrome P450 to metabolize theophylline has been assessed. In all three species the 8-hydroxylation of theophylline to 1,3-dimethyluric acid (1,3-DMU) was the major ...
J O Miners +4 more
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The Role of Oxidative Stress in Periodontitis
Journal of Periodontal Research, EarlyView.Oxidative stress is involved in multiple chemical reactions that take place in different intracellular organelles: mitochondria, rough endoplasmic reticulum, peroxisomes, autophagy, and aging, and can be influenced by exogenous factors: nutrition, physical activity, psychological status, environmental conditions, microbiome, and drugs.
Pedro Bullon +3 more
wiley +1 more source
Prediction of drug-induced liver injury in HepG2 cells cultured with human liver microsomes
, 2015 Drug-induced liver injury (DILI) via metabolic activation by drug-metabolizing enzymes, especially cytochrome P450 (CYP), is a major cause of drug failure and drug withdrawal.
Soo Jin Oh +7 more
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The Journal of Physiology, EarlyView.Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor +4 more
wiley +1 more source
, 2008 A rapid and specific ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS) method was developed for the qualitative and quantitative determination of UGT2B7 activity using 3'-azido-3'-deoxythymidine (AZT) as probe substrate in human ...
Hu, Ying +8 more
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A Hemochromogen Component of Liver Microsomes [PDF]
Proceedings of the National Academy of Sciences, 1952 C F, Strittmatter, E G, Ball
openaire +2 more sources
American Journal of Medical Genetics Part A, Volume 200, Issue 7, Page 1691-1695, July 2026.ABSTRACT Wilson disease (WD) is an autosomal recessive disorder of copper metabolism caused by ATP7B mutations. Diagnosis is usually straightforward in symptomatic patients, but can be challenging in children and adolescents with mild liver disease, borderline urinary copper excretion, or inconclusive genetic findings.
Emanuele Nicastro +10 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, Volume 120, Issue 1, Page 43-54, July 2026.Human radiolabeled mass balance studies are crucial for comprehensively characterizing the absorption, distribution, metabolism, and excretion (ADME) of investigational drugs, providing essential data for drug development, regulatory evaluation, and product labeling.
Jason Boer +24 more
wiley +1 more source
Glucuronidation of diflunisal in liver and kidney microsomes of rat and man.
, 1996 1. The glucuronidation of diflunisal to its phenolic (DPG) and acyl glucuronide (DAG) was measured in vitro using microsomes prepared from rat (n = 4) and human (n = 6) liver and kidney tissue.
Brunelle, F M, Verbeeck, Roger-K.
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