Results 61 to 70 of about 2,738,308 (324)

Vascular disorders of the liver: recommendations from the Italian Association for the Study of the Liver (AISF) ad hoc committee. [PDF]

, 2011
This review summarizes the document elaborated by the Italian Association for the Study of the Liver (AISF) ad hoc committee "Vascular disorders of the liver" on the primary circulatory liver diseases, which include Budd-Chiari syndrome, obstruction of ...
Riggio O, Sacerdoti D, Senzolo M, Primignani M, Italian Association for the Study of the Liver AISF ad hoc committee Vascular disorders of the liver, SACERDOTI, DAVID   +5 more
core   +1 more source

Liver manipulation causes hepatocyte injury and precedes systemic inflammation in patients undergoing liver resection. [PDF]

, 2007
Contains fulltext : 51690.pdf (Publisher’s version ) (Closed access)BACKGROUND: Liver failure following liver surgery is caused by an insufficient functioning remnant cell mass.
Derikx, J.P.M., Peters, Wilbert H M, Poll, M.C. van de, Buurman, Wim A, Roelofs, H.M., Wigmore, S.J., Dejong, Cornelis H C, Roelofs, H.M.J., Derikx, Joep P M, Buurman, W.A., van de Poll, M., van de Poll, Marcel C G, Wigmore, Stephen J, Roelofs, Hennie M J, Dejong, C.H., Peters, W.H.M.   +15 more
core   +2 more sources

Exclusive localization in peroxisomes of dihydroxyacetone phosphate acyltransferase and alkyl-dihydroxyacetone phosphate synthase in rat liver.

Journal of Lipid Research, 1993
Dihydroxyacetone phosphate acyl transferase (DHAP-AT), alkyl dihydroxyacetone phosphate synthase (alkyl-DHAP-synthase), and glycerol-3-phosphate acyltransferase (GPAT) activities were investigated under optimal assay conditions using highly purified ...
H Singh, K Beckman, A Poulos
doaj   +1 more source

Genetic variants of flavin-containing monooxygenases: consequences for drug metabolism [PDF]

, 2010
The metabolism of the anti-tubercular drug, thiacetazone (TAZ) by human FMOs in vitro and the disposition of TAZ in vivo in mice were studied. Reverse phase chromatography confirmed TAZ to be a substrate for human FMO1, FMO2.1 and FMO3 with the ...
Francois, A.
core  

Epoxidation of aldrin by rainbow trout liver microsomes

Assay conditions and analytical methods established for the study of epoxidation of the insecticides aldrin and heptachlor, by rat liver microsomes have been employed to study the same reaction catalyzed by trout liver microsomes.
Chan, Timothy Ming-wai
core   +6 more sources

The Association of Deoxyribonucleic Acid with Liver Microsomes

Journal of Biological Chemistry, 1969
Abstract Rats and mice were given 3H-thymidine, and 18 to 24 hours later nuclei, mitochondria, and microsomes were isolated from the livers by differential centrifugation. The nucleic acids were extracted from the fractions by means of the phenol-sodium dodecyl sulfate procedure.
Schneider, W C, Kuff, E L
openaire   +2 more sources

Use of Clotrimazole in Finfish Aquaculture: Mechanistic Insights, Limitations, and Future Directions for Antifungal Therapy

Animal Research and One Health, EarlyView.
This review critically evaluates clotrimazole as a potential antifungal for finfish aquaculture, highlighting strong mechanistic and in vitro efficacy against aquatic mycoses alongside major gaps in in vivo evidence, toxicokinetics, residue safety, and environmental risk, outlining priorities for responsible therapeutic development and regulatory ...
Arya Sen, Debashri Mondal, Thangapalam Jawahar Abraham   +2 more
wiley   +1 more source

In Vitro Phase I Metabolism of CRV431, a Novel Oral Drug Candidate for Chronic Hepatitis B

Pharmaceutics, 2017
The cytochrome P450-mediated Phase I in vitro metabolism of CRV431 was studied using selective chemical inhibition and recombinant human enzymes. Additionally, the metabolic profile of CRV431 in human, rat, and monkey liver microsomes was investigated ...
Daniel J. Trepanier, Daren R. Ure, Robert T. Foster   +2 more
doaj   +1 more source

Comprehensive Characterization of Acer truncatum Leaf Extract: Identification of Systemic Metabolites and Effects on Performance, Antioxidant Status, and Intestinal Microbiota in Laying Hens

Animal Research and One Health, EarlyView.
Dietary A. truncatum leaf extract is absorbed and improves laying performance in aged hens by enhancing systemic antioxidant capacity and modulating the gut microbiota. ABSTRACT The demand for natural feed additives is considerably increasing in the antibiotic‐free feed era.
Kailong Qin, Jiantao Yang, Minglu Gao, Xiaozhao Tao, Xin Yang, Yanli Liu, Xiaojun Yang   +6 more
wiley   +1 more source

First‐in‐human, phase I, randomized, safety, pharmacokinetic, food‐effect and pharmacodynamic study of a tyrosine kinase 2/Janus kinase 1 inhibitor, SDC‐1801

British Journal of Clinical Pharmacology, EarlyView.
Aim The purpose of this study is to evaluate safety, tolerability, pharmacokinetics (PK), food‐effect (FE) and pharmacodynamics (PD) of an oral tyrosine kinase‐2 (TYK2)/Janus kinase‐1 (JAK1) inhibitor, SDC‐1801, in healthy adult participants. Methods This first‐in‐human study randomized 95 male and female participants.
Chris Brearley, Sam Francis, John Reader, Judi Proctor   +3 more
wiley   +1 more source