Results 61 to 70 of about 34,918 (236)
Scheme for metabolites of 2a observed with human liver microsomes.
, 2018 Scheme for metabolites of 2a observed with human liver microsomes.
Alfin D. N. Vaz (172262) +8 more
core +1 more source
CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 523-539, March 2025.Abstract Ritonavir (RTV) is a potent CYP3A inhibitor that is widely used as a pharmacokinetic (PK) enhancer to increase exposure to select protease inhibitors. However, as a strong and complex perpetrator of CYP3A interactions, RTV can also enhance the exposure of other co‐administered CYP3A substrates, potentially causing toxicity.
Lien Thi Ngo +5 more
wiley +1 more source
Comparative Metabolism of Cinobuafgin in Liver Microsomes from Mouse,Rat,Dog,Pig,Monkey and Human
, 2010 Cinobufagin (CBG), a major bioactive component of Traditional Chinese Medicine Chan-Su with digoxin-like structure, has been reported with Na+-K+-ATPase inhibitory effects and outstanding antitumor activities.
梁思成 +4 more
core
Scheme for metabolites of 1a observed with human liver microsomes.
, 2018 Scheme for metabolites of 1a observed with human liver microsomes.
Alfin D. N. Vaz (172262) +8 more
core +1 more source
Safety Evaluation of an Aqueous Root and Leaf Extract of Ashwagandha (Withania somnifera)
Phytotherapy Research, EarlyView.Sensoril, an aqueous root and leaf extract of ashwagandha showed no evidence of mutagenicity in the in vitro Ames assay, was negative in the in vitro micronucleus, in vivo mammalian bone marrow chromosome aberration assays, and was well tolerated in the rat at up to 4000 mg/kg BW/day when administered orally for a period of 90 days. The data from these
Mukesh Summan +2 more
wiley +1 more source
Characterization Of In Vitro Metabolism of Brucine Using Human Liver Microsomes
, 2010 Background. Brucine, one of the bitter alkaloids isolated from Chinese folk medicine Strychnos nux-vomica L. (Loganiaceae), is known as an effective analgesic and anti- inflammatory agent for relieving arthritic and traumatic pain.
房中则 +4 more
core
H6PDH activity in rat liver, testis and liver parenchymal cell and Leydig cell microsomes.
, 2015 Similar letters showed no significant differences between groups.H6PDH activity in rat liver, testis and liver parenchymal cell and Leydig cell microsomes.
Yuan-Yuan Hu (821108) +10 more
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Journal of Forensic Sciences, EarlyView.Abstract In the present study, the metabolism of khat (Catha edulis) and pseudoephedrine was compared with the aim of identifying objective criteria that could be used to discriminate between them for forensic and doping‐control purposes. An in vitro study using human liver microsomes and an in vivo study using rat urine were performed under harmonized
Jong Suk Park +6 more
wiley +1 more source
Integrative Zoology, EarlyView.Integrated transcriptomic and proteomic analyses were used to validate gonadal development–related genes and to identify a sex‐specific molecular marker in Hucho bleekeri. ABSTRACT Sex determination and differentiation represent fundamental topics in reproductive biology. Sichuan taimen (Hucho bleekeri), a first‐class national protected fish species in
Qinyao Wei +5 more
wiley +1 more source
Impact of incretin analogues on lipid and lipoprotein metabolism in obesity and diabetes
British Journal of Pharmacology, EarlyView.Abstract Incretin‐based therapies have gained momentum as a key strategy for reducing cardiovascular risk in individuals with obesity and/or type 2 diabetes (T2D). It remains unclear whether the cardiovascular benefits reflect a direct reduction in atherogenic lipoproteins—namely, low‐density lipoproteins (LDL), very low‐density lipoproteins (VLDL) and
Andrea Baragetti, Giuseppe Danilo Norata
wiley +1 more source