Results 41 to 50 of about 34,918 (236)
Drug Testing and Analysis, EarlyView.Sensitive LC‐HRMS methods were established for the detection of kisspeptin and its analogues in serum and urine, alongside their analytical and metabolic characterization. Stability studies were conducted in serum, plasma, and urine, highlighting the importance of appropriate sample handling for reliable anti‐doping analysis.
Sophia Krombholz +3 more
wiley +1 more source
Fumonisin B1 metabolism by bovine liver microsomes
, 2001 Only limited and contrasting information is available about the metabolic fate in cattle of fumonisin B1, a mycotoxin produced by moulds of Fusarium. This study was carried out to evaluate the hepatic metabolism of fumonisin B1 by bovine liver microsomes.
F. CALONI, M. SPOTTI, G. POMPA
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Drug Testing and Analysis, EarlyView.Eight metabolites for N‐pyrrolidino fluetonitazene were identified in vitro, three of which (M2, M6 and M8) were present in an authentic urine sample. M2 was the most abundant in vivo metabolite and is a common marker metabolite of nitazepyne‐type substances.
Severin Zemp +6 more
wiley +1 more source
, 2011 Comparative Metabolism of Cinobufagin in Liver Microsomes from Mouse, Rat, Dog, Minipig, Monkey, and HumanCinobufagin (CB), a major bioactive component of the traditional Chinese medicine Chansu, has been reported to have potent antitumor activity.
Ning, Jing +9 more
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Drug Testing and Analysis, EarlyView.A fatal 3‐chloro‐phencyclidine (3‐Cl‐PCP) intoxication was investigated by analyzing postmortem samples and a pooled human liver microsomes assay. Tentative metabolite identification was performed by liquid chromatography‐quadrupole time‐of‐flight mass spectrometry (LC‐QTOF‐MS). Seven phase I metabolites were identified.
Johannes Kutzler +3 more
wiley +1 more source
, 2015 Testosterone hydroxylation was investigated in human, canine and equine liver microsomes and in human and canine single CYPs. The contribution of the CYP families 1, 2 and 3 was studied using chemical inhibitors. Testosterone metabolites were analyzed by
Mevissen, Meike, Zielinski, Jana
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Drug Testing and Analysis, EarlyView.Δ8‐THC and Δ9‐THC showed comparable metabolic profiles. In contrast, Δ10‐THC underwent extensive glucuronidation and hydroxylation, with only minor formation of a carboxy metabolite, indicating a markedly different metabolic pathway. These differences may increase the risk of misidentification and misinterpretation in cannabis drug testing.
Robert Kronstrand +4 more
wiley +1 more source
In Vitro Metabolic Study of Boc5 in human tissues and Animal Liver Microsomes
, 2009 As the first nonpeptidic agonist of glucagon-like peptide 1 receptor, Boc5 can invoke sustained glycemic control and weight loss in diabetic C57BL/6J mice, and has become a promising hit compound for antidiabetic drug. Boc5 displays good efficiency via i.
梁思成 +4 more
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Metabolic activation of 1,1-dichloroethylene by mouse lung and liver microsomes
, 1987 1,1-Dichloroethylene (1,1-DCE) causes lung and liver necrosis in mice. Covalent binding of [14C] 1,1-DCE to isolated lung and liver microsomes from CD-1 mice required NADPH and was strongly inhibited by carbon monoxide.
P. G. Forkert, W. J. Racz, M. Hofley
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UGT1A6 and UGT1A9 involving in the metabolism of daphnetin by human liver microsomes
, 2009 Daphnetin (7, 8-dihydroxycoumarin), one of coumarin derivatives, is the major bioactive constituent from Daphne odora (Thymelaeaceae). Previous studies indicated that daphnetin has the anti-coagulant activity like other coumarin analogs, and other ...
梁思成 +4 more
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