Results 101 to 110 of about 33,787 (250)

Studies on the link between HMG-CoA reductase and cholesterol 7 alpha-hydroxylase in lymph-fistula rats: evidence for both transcriptional and post-transcriptional mechanisms for down-regulation of the two enzymes by bile acids

Journal of Lipid Research, 1993
The mechanism of down-regulation of hepatic HMG-CoA reductase and cholesterol 7 alpha-hydroxylase by cholic acid (CA) and chenodeoxycholic acid (CDCA) was investigated in rats with a lymph fistula.
I Björkhem, U Andersson, E Sudjama-Sugiaman, G Eggertsen, P Hylemon   +4 more
doaj   +1 more source

Effect of soy in men with type 2 diabetes mellitus and subclinical hypogonadism: a randomised controlled study [PDF]

, 2016
Context: Isoflavones found in soy products have a chemical structure similar to estrogen, leading to concerns of an adverse estrogenic effect in men, particularly in those with type 2 diabetes mellitus (T2DM) who have low testosterone levels due to ...
Atkin, Stephen L., Bhasin, Shalender, Kilpatrick, Eric S., Rigby, Alan S., Sathyapalan, Thozhukat, Thatcher, Natalie J.   +5 more
core   +1 more source

Purification and characterization of cholesterol 7 alpha-hydroxylase from rat liver microsomes.

Journal of Biological Chemistry, 1987
Cholesterol 7 alpha-hydroxylase (cholesterol, NADPH: oxygen oxidoreductase, 7 alpha-hydroxylating, EC 1.14.13.17) was purified from liver microsomes of cholestryramine-fed male rats by using high-performance ion-exchange chromatography. The purified enzyme showed a single band on sodium dodecyl sulfate-polyacrylamide gel electrophoresis (Mr = 52,000 ...
T, Ogishima, S, Deguchi, K, Okuda
openaire   +2 more sources

Oxygen‐independent expression of HIF‐1α during the cell cycle in hepatocellular carcinoma cells controls essential metabolic pathways under normoxia

The FEBS Journal, EarlyView.
In Huh7 cells, HIF‐1α is essential as it maintains the expression of proteins involved in glycolysis and steroid/cholesterol biosynthesis both under normoxia and hypoxia. On the other hand, in HeLa cells, these pathways are induced by HIF‐1α only under hypoxia.
Ioanna‐Maria Gkotinakou, Christina Arseni, Kreon Koukoulas, Martina Samiotaki, George Panayotou, George Simos, Ilias Mylonis   +6 more
wiley   +1 more source

7-Hydroxylation of 3-oxygenated C27-, C28-, and C29-steroids in rat liver 18,000 g supernate.

Journal of Lipid Research, 1978
Structurally closely related steroids have been tested as substrates for the NADPH-dependent cholesterol-and cholestanol-7 alpha-hydroxylase(s) considered to be the rate-limiting enzyme(s) in bile acid biosynthesis.
L Aringer
doaj   +1 more source

High cholesterol absorption efficiency interferes with bile acid metabolism and cholesterol elimination from the body

Journal of Internal Medicine, EarlyView.
Abstract Background Elevated low‐density lipoprotein (LDL) cholesterol causes atherosclerotic cardiovascular diseases. Variables of whole‐body cholesterol metabolism, for example, high cholesterol absorption efficiency, might also be atherogenic, whereas the role of bile acids is controversial.
Piia Simonen, Ingmar Wester, Jyri Lommi, Juha Sinisalo, Helena Gylling   +4 more
wiley   +1 more source

Distinct mechanisms of plasma LDL lowering by dietary fiber in the guinea pig: specific effects of pectin, guar gum, and psyllium

Journal of Lipid Research, 1995
Pectin (PE), guar gum (GG), and psyllium (PSY) lower plasma low density lipoprotein (LDL) cholesterol concentrations in guinea pigs with different orders of magnitude by inducing defined alterations in hepatic cholesterol homeostasis (Fernandez et al ...
M L Fernandez
doaj   +1 more source

Reduced Plasma Levels of 25-Hydroxycholesterol and Increased Cerebrospinal Fluid Levels of Bile Acid Precursors in Multiple Sclerosis Patients [PDF]

, 2016
Multiple sclerosis (MS) is an autoimmune, inflammatory disease of the central nervous system (CNS). We have measured the levels of over 20 non-esterified sterols in plasma and cerebrospinal fluid (CSF) from patients suffering from MS, inflammatory CNS ...
A Reboldi, A Saeed, A Solomon, A Szanto, AH Beecham, Andreas W. Sailer, B Goodwin, BA Janowski, C Hong, C Liu, CY Lee, D Meffre, DJ Parks, DR Bauman, DW Russell, F Chalmin, H Lassmann, I Björkhem, I Björkhem, I Björkhem, J Brown III, J Zhang, Jens Kuhle, JG Cyster, JG McDonald, JM Lehmann, Jonas Abdel-Khalik, Juan Zhang, K Park, L Mateos, LH Kasper, M Blanc, M Inoue, M Ogundare, MA Friese, Martin Beibel, N Zelcer, NJ Spann, P Soroosh, Peter J. Crick, PJ Crick, S Hannedouche, S Meaney, S Theofilopoulos, SV Ramagopalan, SY Liu, U Diczfalusy, V Leoni, William J. Griffiths, Y Wang, Yuqin Wang, Z Wang   +51 more
core   +1 more source

Structural Elucidation and Engineering of the (S)‐scoulerine 2‐O‐Methyltransferase Enabling Regioselective Epiberberine Biosynthesis in Coptis chinensis

Plant Biotechnology Journal, EarlyView.
ABSTRACT Protoberberine alkaloids are a characteristic group of natural products in Coptis plants known for their notable pharmacological activities. However, the structural similarity and the substrate promiscuity of their biosynthetic enzymes have left the precise synthetic pathways remain unclarified, posing challenges to regulate product formation.
Jun Song, Di Liu, Shi Chen, Yufeng Tan, Siyu Wang, Shihan Li, Yutong Qin, Guofeng Li, Xufang Tian, Lan Yang, Chong Yuan, Junbo Gou, Wei Huang, Shilin Chen, Yifei Liu   +14 more
wiley   +1 more source

24s-Hydroxycholesterol. Studies on regulatory mechanisms behind its formation in the brain and its potential use as a marker for neurodegeneration [PDF]

, 2010
Cholesterol 24-hydroxylase (CYP46A1) belongs to the cytochrome P450 super family and is responsible for conversion of cholesterol to the oxysterol 24S- hydroxycholesterol (24S-OHC).
Shafaati, Marjan
core