Results 121 to 130 of about 33,787 (250)

EXPRESSION OF ENDOPLASMIC RETICULUM OXIDOREDUCTASES (EROS) AND THEIR ROLE IN THE GI TRACT [PDF]

, 2012
It has been shown that some ER redox enzymes are differentially expressed in stomach and oesophagus tissue. The tissues of the gastrointestinal system, which are subject to external changes of environment during the process of digestion, represent a ...
WATSON, GRAEME
core  

Identification and developmental expression of the full complement of Cytochrome P450 genes in Zebrafish [PDF]

, 2010
Background Increasing use of zebrafish in drug discovery and mechanistic toxicology demands knowledge of cytochrome P450 (CYP) gene regulation and function.
Jared V Goldstone, Andrew G McArthur, Akira Kubota, Juliano Zanette, Thiago Parente, Maria E Jönsson, David R Nelson, John J Stegeman   +7 more
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Effect of cholecystectomy on bile acid synthesis and circulating levels of fibroblast growth factor 19

Annals of Hepatology, 2015
Background and rationale for the study. FGF19/15 is a gut-derived hormone presumably governing bile acid (BA) synthesis and gallbladder (GB) refilling. FGF19 mRNA is present in human GB cholangiocytes (hGBECs); however, the physiological significance of ...
Francisco Barrera, Lorena Azocar, Héctor Molina, Kurt A. Schalper, Marcia Ocares, Jessica Liberona, Luis Villarroel, Fernando Pimentel, Rosa M. Pérez-Ayuso, Flavio Nervi, Albert K. Groen, Juan F. Miquel   +11 more
doaj   +1 more source

Current trends in oxysterol research [PDF]

, 2016
In this short review we provide a synopsis of recent developments in oxysterol research highlighting topics of current interest to the community. These include the involvement of oxysterols in neuronal development and survival, their participation in the
Alvelius, Alwena H. Morgan, Andersson, Arnoldi, Bauman, Blanc, Clayton, Crick, de Medina, Diczfalusy, Dietschy, Eylan Yutuc, Fakheri, Gill, Goyal, Hannedouche, Heverin, Horton, Hu, Iuliano, Iuliano, Janowski, Jansen, Javitt, Jonas Abdel-Khalik, Klinke, Leonarduzzi, Liu, Lütjohann, Maarup, Meaney, Meljon, Murphy, Nelson, Ogundare, Porter, Radhakrishnan, Reboldi, Russell, Sacchetti, Santori, Schroepfer, Shackleton, Song, Soroosh, Theofilopoulos, Theofilopoulos, Thomas Hearn, Tint, Umetani, Wang, Wang, William J. Griffiths, Wu, Yuqin Wang   +54 more
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Neuroendocrine Regulation of Metabolism [PDF]

, 2016
Given the current environment in most developed countries, it is a challenge to maintain a good balance between calories consumed and calories burned, although maintenance of metabolic balance is key to good health. Therefore, understanding how metabolic
Becu Villalobos, D., Coirini, Hector, Cornejo, María Paula, Elias, C. F., Hentges, S.T., Maliqueo, M.   +5 more
core   +3 more sources

Bile acid synthesis in HepG2 cells: effect of cyclosporin

Journal of Lipid Research, 1994
The hypothesis that cyclosporin specifically affects the pathway of bile acid synthesis that begins with 27-hydroxylation of cholesterol was evaluated in HepG2 cells, which synthesize chenodeoxycholic acid and cholic acid from endogenous 7 alpha ...
J Levy, K Budai, N B Javitt
doaj   +1 more source

Effects of drugs and sterols on cholesterol 7 alpha-hydroxylase activity in rat liver microsomes

Journal of Lipid Research, 1983
This study examined the effects of various drugs and sterols on the rate of 7alpha-hydroxycholesterol synthesis in isolated rat liver microsomes. Cholesterol 7alpha-hydroxylase activity was significantly inhibited by proadifen (98%), metyrapone (67%), and aminoglutethimide (45%) at concentrations of 1 mM and by ascorbic acid (40%) at a concentration of
M A Schwartz, S Margolis
openaire   +3 more sources

Hyper- and hypo-responsiveness to dietary fat and cholesterol among inbred mice: searching for level and variability genes

Journal of Lipid Research, 1995
A concept proposed by Berg (Berg, K. 1989. Arteriosclerosis. 9: I-50-I-58) is that a combination of level and variability genes determine an individual's overall plasma lipid levels and atherosclerotic risk.
E A Kirk, G L Moe, M T Caldwell, J A Lernmark, D L Wilson, R C LeBoeuf   +5 more
doaj   +1 more source

Cholesterol and bile acids regulate cholesterol 7 alpha-hydroxylase expression at the transcriptional level in culture and in transgenic mice [PDF]

, 2009
Cholesterol 7 alpha-hydroxylase (7 alpha-hydroxylase) is the rate-limiting enzyme in bile acid biosynthesis. It is subject to a feedback control, whereby high levels of bile acids suppress its activity, and cholesterol exerts a positive control.
Barillas, Carmen, Bashirzadeh, Roya, Gil, Gregorio, Haro, Diego, Karaoglu, Denise, Ramirez, Maria I.   +5 more
core   +1 more source

A novel pathogenic mutation of the CYP27B1 gene in a patient with vitamin D-dependent rickets type 1: a case report [PDF]

, 2014
BACKGROUND: Rickets can occur due to Vitamin D deficiency or defects in its metabolism. Three rare genetic types of rickets with different alterations of genes have been reported, including: Vitamin D dependent rickets type 1, Vitamin D dependent rickets
Abdulrahman MH Al Nemri, Ahmed Al Boukai, Ali Abdu N Al haboob, Ali Al Zahrani, Amir MI Babiker, Hanan Habib, Iman Al Gadi, Nasir AM Al-Jurayyan   +7 more
core   +1 more source