Results 201 to 210 of about 79,855 (290)

Reprogramming SREBP1‐dependent lipogenesis and inflammation in high‐risk breast with licochalcone A: A novel path to cancer prevention

International Journal of Cancer, Volume 158, Issue 7, Page 1927-1940, 1 April 2026.
What's new? Endocrine drugs repurposed from treatment protocols are the primary medications available for breast cancer (BC) prevention in at‐risk women. Adverse effects, however, significantly minimize uptake and prevention impact. Here, the authors investigated licochalcone A (LicA), a non‐endocrine anti‐inflammatory agent with reported hematologic ...
Atieh Hajirahimkhan, Elizabeth T. Bartom, Carolina H. Chung, Xingyu Guo, Kyli Berkley, Seyyedmohsen Hosseinibarkooie, Zahra Assadi, Shao Huan Samuel Weng, Raymond Moellering, Oukseub Lee, Ruohui Chen, Wonhwa Cho, Sriram Chandrasekaran, Susan E. Clare, Seema A. Khan   +14 more
wiley   +1 more source

Nitroxoline mitigates hepatic steatosis by enhancing cholesterol efflux and promoting bile acid synthesis through LRH-1 signaling. [PDF]

Lipids Health Dis
Liu WC, Lien CF, Huang YJ, Lien PY, Chen SJ, Lin CS, Cho RL, Chuang YP.   +7 more
europepmc   +1 more source

Intracellular cholesterol transport proteins: roles in health and disease [PDF]

, 2016
Graham, Annette, Soffientini, Ugo
core   +1 more source

Distinct Proteomic Signatures Driving Progression of Sarcopenia: A Longitudinal Multicohort Study

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.
ABSTRACT Background Sarcopenia is an age‐related condition characterized by progressive muscle mass, strength and physical performance declines, contributing to frailty and adverse health outcomes. Despite increasing interest in molecular biomarkers, longitudinal data with external validation are limited.
Sung Hye Kong, Ok Hee Jeon, Ji Yeon Kim, Miji Kim, Jinhee Kim, Seung Shin Park, Hak Chul Chang, Chang Won Won, Dohyun Han   +8 more
wiley   +1 more source

Mediterranean Diet Modulates Gene Expression of Cholesterol Efflux Receptors in High-Risk Cardiovascular Patients. [PDF]

Mol Nutr Food Res
Hernando-Redondo J, Hernáez Á, Sanllorente A, Pintó X, Estruch R, Salas-Salvadó J, Corella D, Arós F, Martínez-González MÁ, Subirana I, Muñoz-Aguayo D, Malcampo M, Serra-Majem L, Romaguera D, Lapetra J, Ros E, Tinahones F, Lamuela-Raventós RM, Gómez-Gracia E, Fitó M, Castañer O.   +20 more
europepmc   +1 more source

A Pilot Metagenomic Study Demonstrating Virtual Reality Head Mounted Displays Utilized in Medical Education Are Reservoirs of Viable Pathogenic Microbes

MicrobiologyOpen, Volume 15, Issue 2, April 2026.
Metagenomic analysis identified 27 pathogenic bacteria including 4 "ESKAPE" pathogens (Enterobacter sp., Staphylococcus aureus, Klebsiella spp., and Escherichia coli) and numerous organisms associated with ocular infections. A broad range of antimicrobial resistance genes were identified conveying resistance to Methicillin, Aminoglycosides, Macrolides,
Adrian Goldsworthy, Matthew Olsen, Mohd Fairuz Shiratuddin, Simon McKirdy, Rashed Alghafri, Abiola Senok, Hamda Alfalasi, Kok Wai Wong, Lotti Tajouri   +8 more
wiley   +1 more source

USP18 Promotes Cholesterol Efflux and Mitigates Atherosclerosis by Deubiquitinating ABCG1. [PDF]

J Cell Mol Med
An Y, Guo C, Wang X, Liu J, Li Z, Ding J, Zhang Q, Zhou H, Xia B, Wang J, Yu Y, Wan C, Wang J, Dai J.   +13 more
europepmc   +1 more source

Bactericidal, Bacteriostatic, and Fungicidal Activities of Clausena anisata Fruit and Its Compounds, Stigmasteryl 3‐Palmitate (a Phytosterol Ester) and Phellopterin (a Furanocoumarin), Against Some Clinical Pathogens

MicrobiologyOpen, Volume 15, Issue 2, April 2026.
C. anisata fruit extract and its compounds demonstrated potent broad‐spectrum antimicrobial activity, notably against Klebsiella pneumoniae (MIC 0.625 mg/mL; MLC 2.5 mg/mL) and Candida albicans (MIC 0.0781 mg/mL; MLC 0.625 mg/mL). The findings highlight promising bactericidal and fungicidal potential of stigmasteryl 3‐palmitate and phellopterin against
Emmanuel Kofi Kumatia, Alex Asase, Prince Kyei Baffour, Borge Leth Frimpong, Ernest Agyei, Nguyen Huu Tung   +5 more
wiley   +1 more source

The macrophage sterol transport protein ORP2 promotes cholesterol efflux and prevents foam cell formation and atherosclerosis. [PDF]

J Biol Chem
Wang X, Peng K, Zhao Y, Qiu L, Liang C, Dou Y, Dong Q, Ma X, Tang J, Ma Y, Liu L, Zheng M, Yang H, Gao M.   +13 more
europepmc   +1 more source

ApoJ regulates endothelial lipase activity and stability

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Endothelial lipase (EL) is a key regulator of high‐density lipoprotein (HDL) metabolism. Many aspects of EL function remain incompletely understood due to challenges in purifying active EL. This study identifies apolipoprotein J (ApoJ) as a novel chaperone for EL, crucial for its solubility and activity.
Uriel L. Jean‐Baptiste, Simcha R. Singh, Ming J. Wu, Kellen Christina da Cruz Rodriguez, Young‐Bum Kim, Saskia B. Neher   +5 more
wiley   +1 more source