Results 291 to 300 of about 588,707 (355)

Tree shrew model of early diabetic retinopathy reveals microvascular dysfunction and identifies phosphoserine aminotransferase 1 as a novel therapeutic target

Animal Models and Experimental Medicine, EarlyView.
We developed an animal model of early diabetic retinopathy (DR) in the tree shrew by feeding a high‐fat and high‐sugar diet in combination with STZ. Physiological and biochemical index detection, hematoxylin and eosin staining, and transmission electron microscopy were performed to examine DR.
Min Qiu, Shurui Huo, Wenguang Wang, Na Li, Qingwei Zeng, Xiaomei Sun, Jiejie Dai, Pinfen Tong, Yuanyuan Han, Ling Zhao, Caixia Lu   +10 more
wiley   +1 more source

Single-cell profiling deciphering cholesterol metabolism dysregulation in metastatic uveal melanoma and implicating SLC45A2 in its prognosis. [PDF]

Front Immunol
Zhou Y, Cao Y, Li Z, Lei X, Gao Q, Yao W, Guan J, Lu G, Deng H, Zhang L, Deng X, Chen Z, Xing Y.   +12 more
europepmc   +1 more source

Quantitative proteomics identifies clusterin as a novel biomarker for atherosclerosis

Animal Models and Experimental Medicine, EarlyView.
This schematic illustrates the proposed mechanism. In advanced atherosclerotic lesions, upregulated CLU on the cell surface activates low‐density lipoprotein (LDL) receptor‐related protein 1 (LRP1). This interaction triggers the phosphorylation and activation of AKT.
Dengfeng Ding, Yingjie Zhang, Li Zhang, Xinou Zheng, Miaomiao Niu, Yunxiao Jia, Xuezhuang Li, Hua Chen, Chao Guo, Tao Jiang, Yuqiong Zhao   +10 more
wiley   +1 more source

Modified Zhujing pill regulates RPE cholesterol metabolism and gut microbiota in an age-related macular degeneration mouse model. [PDF]

Front Cell Infect Microbiol
Cen S, Xie S, Ibrahim KS, Baran MR, Li X, Reilly J, Tan Z, He Z, Shu X.   +8 more
europepmc   +1 more source

Metabolic considerations of the portal circulation [PDF]

, 1988
Starzl, TE
core  

Molecular mechanism of ischemic postconditioning in promoting diabetic ischemic brain injury repair via the microRNA‐34a–BDNF–SIX3 signaling axis

Animal Models and Experimental Medicine, EarlyView.
Diabetes combined with ischemic stroke (DMIS) exacerbates brain infarct size and neuronal damage compared to nondiabetic ischemic stroke (IS). This study reveals that microRNA‐34a (miR‐34a) plays a key role in DMIS pathogenesis: miR‐34a directly targets and suppresses brain‐derived neurotrophic factor (BDNF) and Sine oculis homeobox 3 (SIX3), promoting
Ling Zhao, Chunlan Zou, Junxian Li, Yang Yang, Yuanyuan Han, Tingyu Ke   +5 more
wiley   +1 more source

Desmosterol as a Novel Biomarker Linking Cholesterol Metabolism, Liver Inflammation, and Cardiovascular Risk in Metabolic Dysfunction-Associated Steatotic Liver Disease. [PDF]

J Atheroscler Thromb
Masaki T.
europepmc   +1 more source

Cholesterol Metabolism-related Characteristics Predict Therapeutic Response and Survival in Esophageal Cancer. [PDF]

J Adv Res
Tan L, Su X, Ma Y, Zeng C, Yue H, Zeng T, Li K, Guo Q, Li Y, Zhang X.   +9 more
europepmc   +1 more source

Polydatin prevents cholesterol gallstone formation by regulating cholesterol metabolism via PPAR-γ signaling. [PDF]

Open Life Sci
Li J, Yu X, Zhou Z.
europepmc   +1 more source

A novel exopolysaccharide from <i>Lactiplantibacillus plantarum</i> H6 improves cholesterol metabolism via <i>Muribaculum-</i>mediated activation of the enterohepatic FXR-FGF15 axis. [PDF]

Gut Microbes
Li Y, Wang J, Wang H, Ma X, Ren D, Wang B.   +5 more
europepmc   +1 more source