Results 131 to 140 of about 274,133 (264)

Mitochondria‐Targeted Multimodal Nanotherapeutics Suppress Oxidized mtDNA‐Driven Inflammation at the Source

Advanced Science, EarlyView.
Ox‐mtDNA fragments escaping from mitochondria drive robust inflammatory responses. A targeted nanoplatform simultaneously inhibits mitochondrial FEN1‐mediated mtDNA cleavage and scavenges ROS, preventing the generation of immunogenic Ox‐mtDNA fragments. The released SeNPs further promote autophagic clearance of cytosolic mtDNA. Consequently, cGAS‐STING,
Wen‐Ling Li, Juan Cao, Yu‐Lin Wang, Yu‐Han Fan, Jia‐Qi Xu, Xian Wu Cheng, Lei Xing, Hu‐Lin Jiang   +7 more
wiley   +1 more source

Hmgcs1 regulates cholesterol synthesis and promotes nerve fiber repair after spinal cord injury. [PDF]

iScience
Pei Y, Feng G, Hu Y, Tang J, Zhang N, Zhou S, Zhang C, Huang F, Zhang L.   +8 more
europepmc   +1 more source

A Dual‐Membrane Biomimetic Nanoplatform Enables Triple‐Modal Therapy Against SARS‐CoV‐2 Through Viral Decoy, Inflammation Neutralizing, and Intracellular RNAi

Advanced Science, EarlyView.
[A&T]MLN is a triple‐modal nanoplatform with siRNA‐loaded LN coated with hybrid ACE2/macrophage membrane. It blocks viral entry, neutralizes IL‐6/IL‐1β/TNF‐α, and delivers siRNA to suppress viral replication. In a murine lung injury model, it attenuates inflammation, offering a multi‐pronged strategy against SARS‐CoV‐2 variants and hyperinflammation ...
Hui Li, Bohan Zhang, Chao Shang, Yi Li, Te Zhao, Shengya Liu, Dan Liu, Junwei Che, Cuiling Zhang, Pinghui Wu, Wenjie Yang, Junjie Ding, Yuhua Ran, Yanan Zhai, Haihua Xiao, Jing Gao, Xiao Li, Chunsheng Gao, Lin Li, Zhiping Li   +19 more
wiley   +1 more source

Human serum cholesterol synthesis

Experimental and Molecular Pathology, 1965
C B, Taylor, B, Mikkelson, J A, Anderson, D T, Forman, S S, Choi   +4 more
openaire   +3 more sources

Glucokinase activity suppresses hepatic cholesterol synthesis and triglyceride accumulation: A new model for the effects of the GKRP P466L common human variant. [PDF]

Mol Metab
Santoleri D, Traynor S, Calhoun RP, Gavin MJ, Merrick D, Seale P, Titchenell PM.   +6 more
europepmc   +1 more source

Ribonucleotides Amplify Mitochondrial DNA‐Driven cGAS–STING Activation via FdUMP‐ribonucleotide Hybrid Particles to Potentiate Chemoimmunotherapy

Advanced Science, EarlyView.
This work develops a metabolic sharing strategy that employs cytidine monophosphate (CMP) to competitively reprogram floxuridine (FUDR) pyrimidine metabolism in colorectal tumor cells. Elevated intracellular FdUMP induces nucleotide imbalance, drives mitochondrial DNA release and cGAS‐STING innate immune cascade activation, and potentiates robust ...
Chao Wang, Chenxuan Zhao, Yesong Yao, Zhiwen Zou, Anxin Shi, Zhuo Feng, Mingkang Yang, Yue Yu, Yang Liu, Xuehui Rui, Jinhui Wu   +10 more
wiley   +1 more source

Tumor Cholesterol Synthesis, Statin Use, and Lethal Prostate Cancer. [PDF]

Mol Cancer Res
Flanagan S, Lis RT, Huang Y, Jehane L, Vaselkiv JB, Allott EH, Finn SP, Lotan TL, Fiorentino M, Loda M, Lee GM, Chakraborty G, Kantoff PW, Mucci LA, Stopsack KH.   +14 more
europepmc   +1 more source

Ultrasound‐Activated Nanoinhibitors Blocking the Chemo‐Immune Checkpoint to Overcome Chemotherapy‐Induced Immune Resistance

Advanced Science, EarlyView.
A sono‐responsive chemo‐immune checkpoint nanoinhibitor (Sono‐TT8) co‐delivering TPZ chemotherapy and siXkr8 simultaneously kills tumor cells and blocks PS externalization, reversing chemotherapy‐induced immunosuppression and enhancing antitumor immunity. ABSTRACT Breast cancer features an immunosuppressive tumor microenvironment following chemotherapy
Yunfan Liu, Chier Du, Leilei Zhu, Hongjin An, Shengzhe Hou, Yi Lan, Xuemei Tang, Min Xu, Peng Luo, Hua Teng, Hao Yang, Xun Guo, Jianli Ren, Zhiyi Zhou   +13 more
wiley   +1 more source

Hepatic management of toxic sterols after acute deletion of Cyp51 from cholesterol synthesis. [PDF]

J Biol Chem
Kreft T, Blagotinšek Cokan K, Skubic C, Režen T, Perše M, Wechtersbach K, Kojc N, Jeruc J, Debeljak Ž, Heffer M, Matz-Soja M, Rozman D.   +11 more
europepmc   +1 more source

Electroacupuncture regulates hepatic cholesterol synthesis by HMGCR deubiquitination in rats. [PDF]

Heliyon, 2023
Jin SW, Han YL, Pan XL, Zhang HX.
europepmc   +1 more source